Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              20     299
NP_570711                                                              18    1482
NP_570712                                                              18    1482
NP_570714                                                              18    1482
NP_570713                                                              18    1482
NP_570716                                                              18    1482
NP_000235                                                              18    1482
NP_570715                                                              18    1482
XP_006718620                                                           18    1482
XP_005274059                                                           18    1482
XP_005274060                                                           18    1482
XP_005274058                                                           18    1482
NP_061159                                                              17    4312
NP_001268885                                                           17    4312
NP_061895                                                              17    4312
XP_005266771                                                           17    4312
XP_005254625                                                           17    4312
XP_005254624                                                           17    4312
NP_848563                                                              16    5631
NP_085126                                                              16    5631
NP_001136116                                                           16    5631
NP_001001669                                                           16    5631
XP_005262409                                                           16    5631
XP_006717990                                                           16    5631
XP_006717989                                                           16    5631
XP_006714848                                                           16    5631
XP_005268504                                                           16    5631
XP_006714847                                                           16    5631
XP_005246927                                                           16    5631
XP_005246925                                                           16    5631
XP_006712841                                                           16    5631
XP_005246924                                                           16    5631
XP_006712840                                                           16    5631
NP_001182201                                                           16    5631
NP_055935                                                              16    7355
NP_036450                                                              16    7355
NP_062535                                                              16    7355
NP_005119                                                              16    7355
XP_006724131                                                           16    7355
XP_005267917                                                           16    7355
XP_005248027                                                           16    7355
XP_006713947                                                           16    7355
NP_006099                                                              15    9605
NP_001276049                                                           15    9605
NP_001276048                                                           15    9605
NP_001276050                                                           15    9605
NP_000566                                                              15    9605
NP_115602                                                              15    9605
NP_004896                                                              15    9605
NP_579920                                                              15    9605
NP_579919                                                              15    9605
NP_579918                                                              15    9605
NP_579916                                                              15    9605
NP_001265551                                                           15    9605
XP_005276831                                                           15    9605
XP_005251669                                                           15    9605
XP_005251668                                                           15    9605
XP_005251666                                                           15    9605
XP_005251665                                                           15    9605
XP_006712095                                                           15    9605
XP_006712094                                                           15    9605
XP_006712093                                                           15    9605
XP_005264429                                                           15    9605
NP_002864                                                              15    9605
NP_579921                                                              15    9605
NP_579922                                                              15    9605
NP_579917                                                              15    9605
NP_060022                                                              15    9605
NP_001229267                                                           15    9605
>NP_000305
          Length = 403

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  NIDDVVRF 9
          NIDDVVRF
Sbjct: 49 NIDDVVRF 56
>NP_570711
          Length = 610

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>NP_570712
          Length = 615

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>NP_570714
          Length = 615

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>NP_570713
          Length = 615

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>NP_570716
          Length = 615

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>NP_000235
          Length = 615

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>NP_570715
          Length = 615

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>XP_006718620
          Length = 610

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>XP_005274059
          Length = 610

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>XP_005274060
          Length = 610

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>XP_005274058
          Length = 610

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          R+IDDVVR
Sbjct: 14 RSIDDVVR 21
>NP_061159
          Length = 1361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RNIDDVVR 8
           RN+DD+ R
Sbjct: 242 RNLDDMAR 249
>NP_001268885
          Length = 3631

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    NIDDVVRF 9
            N++DVV+F
Sbjct: 2814 NLNDVVKF 2821
>NP_061895
          Length = 454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RNIDDVVRF 9
           +N++D+V+F
Sbjct: 327 KNVEDMVQF 335
>XP_005266771
          Length = 313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RNIDDVVRF 9
           +N++D+V+F
Sbjct: 186 KNVEDMVQF 194
>XP_005254625
          Length = 1361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RNIDDVVR 8
           RN+DD+ R
Sbjct: 242 RNLDDMAR 249
>XP_005254624
          Length = 1361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RNIDDVVR 8
           RN+DD+ R
Sbjct: 242 RNLDDMAR 249
>NP_848563
          Length = 747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RNIDDVVRF 9
           +NI D++RF
Sbjct: 156 KNIKDLLRF 164
>NP_085126
          Length = 1671

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNIDDVVR 8
            +NI DVVR
Sbjct: 1463 KNIPDVVR 1470
>NP_001136116
          Length = 1700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNIDDVVR 8
            +NI DVVR
Sbjct: 1463 KNIPDVVR 1470
>NP_001001669
          Length = 675

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NIDDVVR 8
          NIDD+++
Sbjct: 74 NIDDIIK 80
>XP_005262409
          Length = 993

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  DDVVRF 9
          DDV+RF
Sbjct: 15 DDVIRF 20
>XP_006717990
          Length = 175

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  NIDDVV 7
          NIDDVV
Sbjct: 49 NIDDVV 54
>XP_006717989
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  NIDDVV 7
          NIDDVV
Sbjct: 49 NIDDVV 54
>XP_006714848
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NIDDVVR 8
          NIDD+++
Sbjct: 74 NIDDIIK 80
>XP_005268504
          Length = 675

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NIDDVVR 8
          NIDD+++
Sbjct: 74 NIDDIIK 80
>XP_006714847
          Length = 675

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  NIDDVVR 8
          NIDD+++
Sbjct: 74 NIDDIIK 80
>XP_005246927
          Length = 1683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNIDDVVR 8
            +NI DVVR
Sbjct: 1446 KNIPDVVR 1453
>XP_005246925
          Length = 1696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNIDDVVR 8
            +NI DVVR
Sbjct: 1459 KNIPDVVR 1466
>XP_006712841
          Length = 1696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNIDDVVR 8
            +NI DVVR
Sbjct: 1488 KNIPDVVR 1495
>XP_005246924
          Length = 1713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNIDDVVR 8
            +NI DVVR
Sbjct: 1476 KNIPDVVR 1483
>XP_006712840
          Length = 1725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNIDDVVR 8
            +NI DVVR
Sbjct: 1488 KNIPDVVR 1495
>NP_001182201
          Length = 993

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  DDVVRF 9
          DDV+RF
Sbjct: 15 DDVIRF 20
>NP_055935
          Length = 4169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  NIDDVV 7
          N+DDVV
Sbjct: 37 NVDDVV 42
>NP_036450
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NIDDVVR 8
           NIDD+V+
Sbjct: 684 NIDDLVK 690
>NP_062535
          Length = 2146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1    RNIDDVVR 8
            +N+DD+++
Sbjct: 1817 KNVDDILK 1824
>NP_005119
          Length = 2298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    RNIDDVVR 8
            +N+DD+V+
Sbjct: 1547 KNLDDLVK 1554
>XP_006724131
          Length = 2298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    RNIDDVVR 8
            +N+DD+V+
Sbjct: 1547 KNLDDLVK 1554
>XP_005267917
          Length = 2061

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 1    RNIDDVVR 8
            +N+DD+++
Sbjct: 1817 KNVDDILK 1824
>XP_005248027
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NIDDVVR 8
           NIDD+V+
Sbjct: 379 NIDDLVK 385
>XP_006713947
          Length = 738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NIDDVVR 8
           NIDD+V+
Sbjct: 683 NIDDLVK 689
>NP_006099
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   NIDDVV 7
           N+DD+V
Sbjct: 421 NVDDIV 426
>NP_001276049
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          +++DDV+R
Sbjct: 43 QDLDDVIR 50
>NP_001276048
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          +++DDV+R
Sbjct: 43 QDLDDVIR 50
>NP_001276050
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          +++DDV+R
Sbjct: 43 QDLDDVIR 50
>NP_000566
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NIDDVVRF 9
           N+D+ V+F
Sbjct: 159 NLDEAVKF 166
>NP_115602
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          +++DDV+R
Sbjct: 43 QDLDDVIR 50
>NP_004896
          Length = 224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   RNIDDVVR 8
           RN D+++R
Sbjct: 155 RNFDEILR 162
>NP_579920
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 453 IDDIVR 458
>NP_579919
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 367 IDDIVR 372
>NP_579918
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 288 IDDIVR 293
>NP_579916
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 453 IDDIVR 458
>NP_001265551
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 453 IDDIVR 458
>XP_005276831
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 288 IDDIVR 293
>XP_005251669
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          +++DDV+R
Sbjct: 43 QDLDDVIR 50
>XP_005251668
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          +++DDV+R
Sbjct: 43 QDLDDVIR 50
>XP_005251666
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          +++DDV+R
Sbjct: 43 QDLDDVIR 50
>XP_005251665
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RNIDDVVR 8
          +++DDV+R
Sbjct: 43 QDLDDVIR 50
>XP_006712095
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NIDDVVRF 9
           NID  VRF
Sbjct: 406 NIDKSVRF 413
>XP_006712094
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NIDDVVRF 9
           NID  VRF
Sbjct: 406 NIDKSVRF 413
>XP_006712093
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NIDDVVRF 9
           NID  VRF
Sbjct: 406 NIDKSVRF 413
>XP_005264429
          Length = 1472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NIDDVVRF 9
           NID  VRF
Sbjct: 406 NIDKSVRF 413
>NP_002864
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 453 IDDIVR 458
>NP_579921
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 453 IDDIVR 458
>NP_579922
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 453 IDDIVR 458
>NP_579917
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IDDVVR 8
           IDD+VR
Sbjct: 464 IDDIVR 469
>NP_060022
          Length = 1458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NIDDVVRF 9
           NID  VRF
Sbjct: 392 NIDKSVRF 399
>NP_001229267
          Length = 1453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   NIDDVVRF 9
           NID  VRF
Sbjct: 392 NIDKSVRF 399
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.156    0.457 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 435,889
Number of extensions: 636
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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