Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           21     229
NP_000170                                                              21     229
XP_005264328                                                           21     229
NP_001268422                                                           19     869
NP_001268423                                                           19     869
NP_776253                                                              18    1482
XP_005245126                                                           18    1482
NP_001243351                                                           17    2528
NP_001243350                                                           17    2528
NP_116106                                                              17    2528
XP_005263371                                                           17    2528
NP_001184216                                                           17    3301
XP_005268734                                                           17    3301
XP_006710290                                                           17    3301
NP_039224                                                              17    3301
NP_689653                                                              17    3301
NP_001013372                                                           17    3301
NP_001005239                                                           17    3301
NP_037423                                                              17    4312
NP_115818                                                              17    4312
NP_001005408                                                           17    4312
XP_006716613                                                           17    4312
XP_006716612                                                           17    4312
XP_006716611                                                           17    4312
NP_057336                                                              16    5631
NP_060037                                                              16    5631
NP_001094385                                                           16    5631
XP_005255865                                                           16    5631
XP_006721206                                                           16    5631
XP_006712120                                                           16    5631
XP_005264512                                                           16    5631
XP_005264511                                                           16    5631
XP_006712119                                                           16    5631
XP_005264510                                                           16    5631
XP_006712118                                                           16    5631
XP_005264509                                                           16    5631
XP_005264508                                                           16    5631
XP_006712117                                                           16    5631
XP_005264507                                                           16    5631
XP_005264506                                                           16    5631
NP_004963                                                              16    7355
NP_001121902                                                           16    7355
NP_859075                                                              16    7355
NP_001121901                                                           16    7355
NP_064544                                                              16    7355
NP_001241878                                                           16    7355
XP_006719432                                                           16    7355
XP_006719431                                                           16    7355
XP_005251512                                                           16    7355
XP_006714340                                                           16    7355
XP_006714339                                                           16    7355
XP_006714338                                                           16    7355
NP_001001392                                                           15    9605
NP_006028                                                              15    9605
NP_001265596                                                           15    9605
NP_057361                                                              15    9605
NP_899050                                                              15    9605
NP_001019554                                                           15    9605
NP_001265597                                                           15    9605
NP_001265595                                                           15    9605
NP_060876                                                              15    9605
NP_003363                                                              15    9605
NP_699188                                                              15    9605
NP_055718                                                              15    9605
NP_002283                                                              15    9605
XP_005256545                                                           15    9605
XP_006719739                                                           15    9605
XP_006719738                                                           15    9605
XP_005269272                                                           15    9605
XP_005249236                                                           15    9605
XP_005265184                                                           15    9605
XP_006712940                                                           15    9605
XP_005270979                                                           15    9605
NP_001094386                                                           15    9605
NP_056972                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RMVTGNGAL 9
           RMVTGNG+L
Sbjct: 172 RMVTGNGSL 180
>NP_000170
          Length = 1360

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RMVTGNGAL 9
           RMVTGNG+L
Sbjct: 302 RMVTGNGSL 310
>XP_005264328
          Length = 1261

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RMVTGNGAL 9
           RMVTGNG+L
Sbjct: 203 RMVTGNGSL 211
>NP_001268422
          Length = 1058

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2 MVTGNGAL 9
         MVTGNG+L
Sbjct: 1 MVTGNGSL 8
>NP_001268423
          Length = 1058

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2 MVTGNGAL 9
         MVTGNG+L
Sbjct: 1 MVTGNGSL 8
>NP_776253
          Length = 513

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RMVTGNGAL 9
           RM+TGN AL
Sbjct: 174 RMITGNMAL 182
>XP_005245126
          Length = 513

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RMVTGNGAL 9
           RM+TGN AL
Sbjct: 174 RMITGNMAL 182
>NP_001243351
          Length = 434

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RMVTGNGAL 9
           +M+ GNG+L
Sbjct: 425 KMIVGNGSL 433
>NP_001243350
          Length = 434

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RMVTGNGAL 9
           +M+ GNG+L
Sbjct: 425 KMIVGNGSL 433
>NP_116106
          Length = 434

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RMVTGNGAL 9
           +M+ GNG+L
Sbjct: 425 KMIVGNGSL 433
>XP_005263371
          Length = 526

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RMVTGNGAL 9
           +M+ GNG+L
Sbjct: 517 KMIVGNGSL 525
>NP_001184216
          Length = 326

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VTGNGAL 9
          +TGNGA+
Sbjct: 54 ITGNGAI 60
>XP_005268734
          Length = 468

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RMVTGNGAL 9
           ++VTG GAL
Sbjct: 103 KVVTGRGAL 111
>XP_006710290
          Length = 574

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RMVTGNGAL 9
          R +TG GAL
Sbjct: 4  RSITGEGAL 12
>NP_039224
          Length = 307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VTGNGAL 9
          VTGNGA+
Sbjct: 37 VTGNGAV 43
>NP_689653
          Length = 445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RMVTGNGAL 9
           ++VTG GAL
Sbjct: 103 KVVTGRGAL 111
>NP_001013372
          Length = 326

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VTGNGAL 9
          +TGNGA+
Sbjct: 54 ITGNGAI 60
>NP_001005239
          Length = 326

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VTGNGAL 9
          +TGNGA+
Sbjct: 54 ITGNGAI 60
>NP_037423
          Length = 1443

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           +VTG GAL
Sbjct: 954 LVTGRGAL 961
>NP_115818
          Length = 1562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           M+TGNG +
Sbjct: 608 MMTGNGVM 615
>NP_001005408
          Length = 1560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           M+TGNG +
Sbjct: 608 MMTGNGVM 615
>XP_006716613
          Length = 785

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           +VTG GAL
Sbjct: 296 LVTGRGAL 303
>XP_006716612
          Length = 1365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           +VTG GAL
Sbjct: 876 LVTGRGAL 883
>XP_006716611
          Length = 1440

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           +VTG GAL
Sbjct: 954 LVTGRGAL 961
>NP_057336
          Length = 4857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>NP_060037
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RMVTGNGAL 9
          R VTG+GA+
Sbjct: 12 REVTGSGAV 20
>NP_001094385
          Length = 926

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VTGNGAL 9
           +TGNG L
Sbjct: 318 ITGNGVL 324
>XP_005255865
          Length = 917

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VTGNGAL 9
           +TGNG L
Sbjct: 318 ITGNGVL 324
>XP_006721206
          Length = 921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VTGNGAL 9
           +TGNG L
Sbjct: 313 ITGNGVL 319
>XP_006712120
          Length = 4812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264512
          Length = 4840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264511
          Length = 4847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_006712119
          Length = 4851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264510
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_006712118
          Length = 4864

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264509
          Length = 4870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264508
          Length = 4875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_006712117
          Length = 4878

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264507
          Length = 4880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264506
          Length = 4884

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2 MVTGNGA 8
         MVTG GA
Sbjct: 1 MVTGGGA 7
>NP_004963
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           ++TGNG +
Sbjct: 289 IITGNGGI 296
>NP_001121902
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MVTGNG 7
           M+TGNG
Sbjct: 475 MLTGNG 480
>NP_859075
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RMVTGNGA 8
           RMV G GA
Sbjct: 198 RMVEGRGA 205
>NP_001121901
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MVTGNG 7
           M+TGNG
Sbjct: 475 MLTGNG 480
>NP_064544
          Length = 1026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MVTGNG 7
           M+TGNG
Sbjct: 475 MLTGNG 480
>NP_001241878
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  MVTGNG 7
          M+TGNG
Sbjct: 45 MLTGNG 50
>XP_006719432
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RMVTGNGA 8
           RMV G GA
Sbjct: 198 RMVEGRGA 205
>XP_006719431
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RMVTGNGA 8
           RMV G GA
Sbjct: 198 RMVEGRGA 205
>XP_005251512
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           ++TGNG +
Sbjct: 289 IITGNGGI 296
>XP_006714340
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MVTGNG 7
           M+TGNG
Sbjct: 475 MLTGNG 480
>XP_006714339
          Length = 795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MVTGNG 7
           M+TGNG
Sbjct: 242 MLTGNG 247
>XP_006714338
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MVTGNG 7
           M+TGNG
Sbjct: 445 MLTGNG 450
>NP_001001392
          Length = 139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RMVTGNGA 8
           + V+GNGA
Sbjct: 116 QQVSGNGA 123
>NP_006028
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           +VTG GAL
Sbjct: 429 LVTGLGAL 436
>NP_001265596
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MVTGNGAL 9
          +V GNGA+
Sbjct: 13 VVVGNGAV 20
>NP_057361
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MVTGNGAL 9
          +V GNGA+
Sbjct: 13 VVVGNGAV 20
>NP_899050
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MVTGNGAL 9
          +V GNGA+
Sbjct: 13 VVVGNGAV 20
>NP_001019554
          Length = 2385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TGNGAL 9
           TGNGA+
Sbjct: 609 TGNGAV 614
>NP_001265597
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MVTGNGAL 9
          +V GNGA+
Sbjct: 13 VVVGNGAV 20
>NP_001265595
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MVTGNGAL 9
          +V GNGA+
Sbjct: 13 VVVGNGAV 20
>NP_060876
          Length = 5412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RMVTGN 6
           R+VTGN
Sbjct: 515 RLVTGN 520
>NP_003363
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2  MVTGNG 7
          M TGNG
Sbjct: 13 MATGNG 18
>NP_699188
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VTGNGA 8
           +TGNGA
Sbjct: 170 LTGNGA 175
>NP_055718
          Length = 2363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TGNGAL 9
           TGNGA+
Sbjct: 609 TGNGAV 614
>NP_002283
          Length = 1798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RMVTGNG 7
           R+VTG G
Sbjct: 495 RLVTGRG 501
>XP_005256545
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VTGNGA 8
           +TGNGA
Sbjct: 146 LTGNGA 151
>XP_006719739
          Length = 2306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TGNGAL 9
           TGNGA+
Sbjct: 552 TGNGAV 557
>XP_006719738
          Length = 2340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TGNGAL 9
           TGNGA+
Sbjct: 586 TGNGAV 591
>XP_005269272
          Length = 2356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TGNGAL 9
           TGNGA+
Sbjct: 609 TGNGAV 614
>XP_005249236
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MVTGNGAL 9
          +V GNGA+
Sbjct: 13 VVVGNGAV 20
>XP_005265184
          Length = 1798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RMVTGNG 7
           R+VTG G
Sbjct: 495 RLVTGRG 501
>XP_006712940
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   MVTGNGAL 9
           +VTG GAL
Sbjct: 453 LVTGLGAL 460
>XP_005270979
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RMVTGNGA 8
           R+V+G GA
Sbjct: 684 RLVSGGGA 691
>NP_001094386
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MVTGNGAL 9
          ++TG GAL
Sbjct: 44 LLTGGGAL 51
>NP_056972
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RMVTGNGA 8
           R+V+G GA
Sbjct: 684 RLVSGGGA 691
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.136    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 714,442
Number of extensions: 1059
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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