Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_001164120                                                           17    3301
NP_112483                                                              17    3301
NP_001096078                                                           17    3301
XP_005262363                                                           17    3301
XP_005262362                                                           17    3301
XP_005262361                                                           17    3301
XP_005262360                                                           17    3301
XP_005262358                                                           17    3301
XP_006715077                                                           17    3301
XP_005247178                                                           17    3301
NP_005624                                                              16    5631
NP_001093156                                                           16    5631
NP_071336                                                              16    5631
NP_620714                                                              16    5631
NP_008870                                                              16    5631
XP_005268078                                                           16    5631
XP_006718519                                                           16    5631
XP_006718517                                                           16    5631
XP_006718516                                                           16    5631
XP_006718515                                                           16    5631
XP_006718514                                                           16    5631
XP_005273885                                                           16    5631
XP_005273884                                                           16    5631
XP_005273883                                                           16    5631
XP_005273882                                                           16    5631
XP_005273881                                                           16    5631
XP_005264572                                                           16    5631
NP_062550                                                              16    7355
NP_001008212                                                           16    7355
NP_068815                                                              16    7355
NP_001008214                                                           16    7355
NP_001008213                                                           16    7355
NP_002433                                                              16    7355
NP_116575                                                              16    7355
NP_001263397                                                           16    7355
NP_001469                                                              16    7355
NP_001263398                                                           16    7355
XP_006719467                                                           16    7355
XP_006719466                                                           16    7355
XP_006719394                                                           16    7355
XP_005268830                                                           16    7355
XP_005252395                                                           16    7355
NP_078966                                                              15    9605
NP_055558                                                              15    9605
NP_001094060                                                           15    9605
NP_001164121                                                           15    9605
NP_002354                                                              15    9605
NP_803134                                                              15    9605
NP_998821                                                              15    9605
NP_796379                                                              15    9605
XP_005248098                                                           15    9605
XP_006713998                                                           15    9605
XP_006713997                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RLTTYRSRS 9
            R TTYRSRS
Sbjct: 3827 RHTTYRSRS 3835
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RLTTYRSRS 9
            R TTYRSRS
Sbjct: 3819 RHTTYRSRS 3827
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RLTTYRSRS 9
            R TTYRSRS
Sbjct: 3780 RHTTYRSRS 3788
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RLTTYRSRS 9
            R TTYRSRS
Sbjct: 3859 RHTTYRSRS 3867
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RLTTYRSRS 9
            R TTYRSRS
Sbjct: 3872 RHTTYRSRS 3880
>NP_001164120
          Length = 717

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RLTTYRSRS 9
          R+T +RSRS
Sbjct: 72 RITVWRSRS 80
>NP_112483
          Length = 734

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RLTTYRSRS 9
          R+T +RSRS
Sbjct: 72 RITVWRSRS 80
>NP_001096078
          Length = 2263

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    LTTYRSR 8
            LTTYRS+
Sbjct: 2035 LTTYRSK 2041
>XP_005262363
          Length = 489

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RLTTYRSRS 9
          R+T +RSRS
Sbjct: 72 RITVWRSRS 80
>XP_005262362
          Length = 490

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RLTTYRSRS 9
          R+T +RSRS
Sbjct: 72 RITVWRSRS 80
>XP_005262361
          Length = 536

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RLTTYRSRS 9
          R+T +RSRS
Sbjct: 72 RITVWRSRS 80
>XP_005262360
          Length = 557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RLTTYRSRS 9
          R+T +RSRS
Sbjct: 72 RITVWRSRS 80
>XP_005262358
          Length = 733

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RLTTYRSRS 9
          R+T +RSRS
Sbjct: 72 RITVWRSRS 80
>XP_006715077
          Length = 140

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RLTTYRSRS 9
          R T YRSRS
Sbjct: 71 RKTLYRSRS 79
>XP_005247178
          Length = 2263

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    LTTYRSR 8
            LTTYRS+
Sbjct: 2035 LTTYRSK 2041
>NP_005624
          Length = 1333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LTTYRS 7
           LTTYRS
Sbjct: 628 LTTYRS 633
>NP_001093156
          Length = 626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RLTTYRSR 8
           R+TT+R+R
Sbjct: 98  RITTWRNR 105
>NP_071336
          Length = 626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RLTTYRSR 8
           R+TT+R+R
Sbjct: 98  RITTWRNR 105
>NP_620714
          Length = 752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>NP_008870
          Length = 1332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LTTYRS 7
           LTTYRS
Sbjct: 626 LTTYRS 631
>XP_005268078
          Length = 1272

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LTTYRS 7
           LTTYRS
Sbjct: 566 LTTYRS 571
>XP_006718519
          Length = 517

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_006718517
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_006718516
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_006718515
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_006718514
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_005273885
          Length = 591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_005273884
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_005273883
          Length = 667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_005273882
          Length = 679

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_005273881
          Length = 751

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTTYRS 7
          LTTYRS
Sbjct: 26 LTTYRS 31
>XP_005264572
          Length = 1318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LTTYRS 7
           LTTYRS
Sbjct: 628 LTTYRS 633
>NP_062550
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTTYRSRS 9
           L +YRSRS
Sbjct: 330 LESYRSRS 337
>NP_001008212
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTTYRSRS 9
           L+ YRSRS
Sbjct: 211 LSKYRSRS 218
>NP_068815
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTTYRSRS 9
           L+ YRSRS
Sbjct: 211 LSKYRSRS 218
>NP_001008214
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTTYRSRS 9
           L+ YRSRS
Sbjct: 211 LSKYRSRS 218
>NP_001008213
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTTYRSRS 9
           L+ YRSRS
Sbjct: 211 LSKYRSRS 218
>NP_002433
          Length = 362

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TTYRSRS 9
           TTY SRS
Sbjct: 225 TTYASRS 231
>NP_116575
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RLTTYRSR 8
           R T+YRSR
Sbjct: 127 RNTSYRSR 134
>NP_001263397
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RLTTYRSRS 9
           +L TY SRS
Sbjct: 166 QLVTYSSRS 174
>NP_001469
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RLTTYRSRS 9
           +L TY SRS
Sbjct: 221 QLVTYSSRS 229
>NP_001263398
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RLTTYRSRS 9
           +L TY SRS
Sbjct: 221 QLVTYSSRS 229
>XP_006719467
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  TTYRSRS 9
          TTY SRS
Sbjct: 87 TTYASRS 93
>XP_006719466
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TTYRSRS 9
           TTY SRS
Sbjct: 225 TTYASRS 231
>XP_006719394
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RLTTYRSRS 9
           +L TY SRS
Sbjct: 221 QLVTYSSRS 229
>XP_005268830
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RLTTYRSRS 9
           +L TY SRS
Sbjct: 221 QLVTYSSRS 229
>XP_005252395
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTTYRSRS 9
           L+ YRSRS
Sbjct: 154 LSKYRSRS 161
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RLTTYR 6
            RLTTY+
Sbjct: 5697 RLTTYK 5702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RLTTYR 6
            RLTTY+
Sbjct: 7753 RLTTYK 7758
>NP_055558
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TTYRSR 8
           TTYR+R
Sbjct: 422 TTYRNR 427
>NP_001094060
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TTYRSR 8
           TTYR+R
Sbjct: 422 TTYRNR 427
>NP_001164121
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RLTTYRSR 8
          R+T +RSR
Sbjct: 72 RITVWRSR 79
>NP_002354
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TTYRSRS 9
           TT+R+RS
Sbjct: 330 TTFRARS 336
>NP_803134
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TTYRSRS 9
           TT+R+RS
Sbjct: 330 TTFRARS 336
>NP_998821
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LTTYRS 7
           +TTYRS
Sbjct: 393 ITTYRS 398
>NP_796379
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TTYRSRS 9
           TT+R+RS
Sbjct: 330 TTFRARS 336
>XP_005248098
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TTYRSR 8
           TTYR+R
Sbjct: 313 TTYRNR 318
>XP_006713998
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TTYRSR 8
           TTYR+R
Sbjct: 422 TTYRNR 427
>XP_006713997
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TTYRSR 8
           TTYR+R
Sbjct: 422 TTYRNR 427
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.122    0.321 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 461,083
Number of extensions: 462
Number of successful extensions: 59
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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