Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     390
NP_036462                                                              20     390
NP_001243397                                                           20     390
XP_005269721                                                           20     390
NP_001275705                                                           16    7355
NP_004415                                                              16    7355
XP_006720920                                                           16    7355
XP_005255212                                                           16    7355
NP_055497                                                              15    9605
NP_064504                                                              15    9605
NP_078901                                                              15    9605
XP_006726265                                                           15    9605
XP_006726264                                                           15    9605
XP_006726228                                                           15    9605
XP_006726227                                                           15    9605
XP_005277331                                                           15    9605
XP_006726127                                                           15    9605
XP_006726126                                                           15    9605
XP_006726028                                                           15    9605
XP_006726027                                                           15    9605
XP_006725940                                                           15    9605
XP_006725939                                                           15    9605
XP_005259193                                                           15    9605
XP_005259192                                                           15    9605
XP_005277373                                                           15    9605
XP_005277372                                                           15    9605
XP_005277141                                                           15    9605
XP_005277142                                                           15    9605
XP_005278344                                                           15    9605
XP_005278345                                                           15    9605
XP_005252887                                                           15    9605
XP_005252886                                                           15    9605
XP_006716553                                                           15    9605
XP_006716552                                                           15    9605
XP_006716551                                                           15    9605
XP_006716550                                                           15    9605
XP_005250558                                                           15    9605
NP_001004                                                              15    9605
NP_055870                                                              15    9605
>NP_001243398
          Length = 1781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RLQTQVASK 9
            RLQTQ+ASK
Sbjct: 1620 RLQTQIASK 1628
>NP_036462
          Length = 2073

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RLQTQVASK 9
            RLQTQ+ASK
Sbjct: 1912 RLQTQIASK 1920
>NP_001243397
          Length = 1890

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RLQTQVASK 9
            RLQTQ+ASK
Sbjct: 1729 RLQTQIASK 1737
>XP_005269721
          Length = 2073

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RLQTQVASK 9
            RLQTQ+ASK
Sbjct: 1912 RLQTQIASK 1920
>NP_001275705
          Length = 654

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LQTQVASK 9
           L+TQVAS+
Sbjct: 420 LETQVASE 427
>NP_004415
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LQTQVASK 9
           L+TQVAS+
Sbjct: 420 LETQVASE 427
>XP_006720920
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LQTQVASK 9
           L+TQVAS+
Sbjct: 421 LETQVASE 428
>XP_005255212
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LQTQVASK 9
           L+TQVAS+
Sbjct: 473 LETQVASE 480
>NP_055497
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RLQTQVAS 8
           +LQTQ+ S
Sbjct: 949 KLQTQITS 956
>NP_064504
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LQTQVASK 9
           +QT +ASK
Sbjct: 667 IQTNIASK 674
>NP_078901
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LQTQVASK 9
           +QT +ASK
Sbjct: 667 IQTNIASK 674
>XP_006726265
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_006726264
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_006726228
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_006726227
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005277331
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_006726127
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_006726126
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_006726028
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_006726027
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_006725940
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_006725939
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005259193
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005259192
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005277373
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005277372
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005277141
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005277142
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005278344
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005278345
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>XP_005252887
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 227 RLQTQV 232
>XP_005252886
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 318 RLQTQV 323
>XP_006716553
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RLQTQVAS 8
           +LQTQ+ S
Sbjct: 867 KLQTQITS 874
>XP_006716552
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RLQTQVAS 8
           +LQTQ+ S
Sbjct: 949 KLQTQITS 956
>XP_006716551
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RLQTQVAS 8
           +LQTQ+ S
Sbjct: 949 KLQTQITS 956
>XP_006716550
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RLQTQVAS 8
           +LQTQ+ S
Sbjct: 949 KLQTQITS 956
>XP_005250558
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LQTQVASK 9
           +QT +ASK
Sbjct: 789 IQTNIASK 796
>NP_001004
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 109 RLQTQV 114
>NP_055870
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RLQTQV 6
           RLQTQV
Sbjct: 376 RLQTQV 381
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.112    0.256 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 250,132
Number of extensions: 303
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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