Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     299
NP_671714                                                              20     299
XP_006715890                                                           20     299
XP_005250160                                                           20     299
XP_005250159                                                           20     299
NP_000466                                                              17    3301
NP_001276953                                                           17    4312
NP_714912                                                              17    4312
NP_001276952                                                           17    4312
NP_005526                                                              17    4312
XP_006722804                                                           17    4312
NP_055084                                                              16    5631
NP_001265055                                                           16    5631
NP_001265056                                                           16    5631
NP_001124177                                                           16    5631
NP_001124175                                                           16    5631
NP_001124176                                                           16    5631
NP_060034                                                              16    5631
NP_001265054                                                           16    5631
XP_006719539                                                           16    5631
XP_005262762                                                           16    5631
XP_005262761                                                           16    5631
NP_001166155                                                           16    7355
NP_003804                                                              16    7355
NP_443072                                                              16    7355
NP_066959                                                              16    7355
XP_005265665                                                           16    7355
XP_005265664                                                           16    7355
XP_005265663                                                           16    7355
XP_006713485                                                           16    7355
XP_005265662                                                           16    7355
NP_001239                                                              16    7355
NP_149347                                                              15    9605
NP_004333                                                              15    9605
NP_149130                                                              15    9605
NP_149129                                                              15    9605
NP_149131                                                              15    9605
NP_001265455                                                           15    9605
NP_071400                                                              15    9605
NP_001265454                                                           15    9605
NP_001265453                                                           15    9605
NP_055641                                                              15    9605
NP_055618                                                              15    9605
NP_001095841                                                           15    9605
NP_079231                                                              15    9605
NP_003598                                                              15    9605
XP_006724655                                                           15    9605
XP_006724383                                                           15    9605
XP_006716202                                                           15    9605
XP_006716201                                                           15    9605
XP_006716200                                                           15    9605
XP_006716199                                                           15    9605
XP_005273378                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RLQFETADN 9
            RLQFETAD+
Sbjct: 3536 RLQFETADD 3544
>NP_671714
          Length = 3899

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RLQFETADN 9
            RLQFETAD+
Sbjct: 3528 RLQFETADD 3536
>XP_006715890
          Length = 3860

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RLQFETADN 9
            RLQFETAD+
Sbjct: 3489 RLQFETADD 3497
>XP_005250160
          Length = 3939

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RLQFETADN 9
            RLQFETAD+
Sbjct: 3568 RLQFETADD 3576
>XP_005250159
          Length = 3952

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RLQFETADN 9
            RLQFETAD+
Sbjct: 3581 RLQFETADD 3589
>NP_000466
          Length = 470

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RLQFETAD 8
           RLQFET +
Sbjct: 303 RLQFETVE 310
>NP_001276953
          Length = 702

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+++ET DN
Sbjct: 196 RMEWETPDN 204
>NP_714912
          Length = 381

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+++ET DN
Sbjct: 156 RMEWETPDN 164
>NP_001276952
          Length = 660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+++ET DN
Sbjct: 156 RMEWETPDN 164
>NP_005526
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+++ET DN
Sbjct: 156 RMEWETPDN 164
>XP_006722804
          Length = 674

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+++ET DN
Sbjct: 156 RMEWETPDN 164
>NP_055084
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           R++FE  DN
Sbjct: 174 RMEFEEIDN 182
>NP_001265055
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           R++FE  DN
Sbjct: 174 RMEFEEIDN 182
>NP_001265056
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           R++FE  DN
Sbjct: 174 RMEFEEIDN 182
>NP_001124177
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           R++FE  DN
Sbjct: 174 RMEFEEIDN 182
>NP_001124175
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           R++FE  DN
Sbjct: 174 RMEFEEIDN 182
>NP_001124176
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           R++FE  DN
Sbjct: 174 RMEFEEIDN 182
>NP_060034
          Length = 2551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LQFETADN 9
           +QF T DN
Sbjct: 616 IQFNTTDN 623
>NP_001265054
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           R++FE  DN
Sbjct: 174 RMEFEEIDN 182
>XP_006719539
          Length = 2246

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LQFETADN 9
           +QF T DN
Sbjct: 616 IQFNTTDN 623
>XP_005262762
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           R++FE  DN
Sbjct: 174 RMEFEEIDN 182
>XP_005262761
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           R++FE  DN
Sbjct: 174 RMEFEEIDN 182
>NP_001166155
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RLQFETADN 9
          RL F TAD+
Sbjct: 17 RLGFSTADS 25
>NP_003804
          Length = 722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           +L+FE A+N
Sbjct: 184 QLEFEEAEN 192
>NP_443072
          Length = 481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RLQFETADN 9
          RL F TAD+
Sbjct: 17 RLGFSTADS 25
>NP_066959
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LQFETADN 9
           L +ETA+N
Sbjct: 366 LSYETAEN 373
>XP_005265665
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           RLQ ETA N
Sbjct: 146 RLQNETAAN 154
>XP_005265664
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           RLQ ETA N
Sbjct: 146 RLQNETAAN 154
>XP_005265663
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           RLQ ETA N
Sbjct: 146 RLQNETAAN 154
>XP_006713485
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           RLQ ETA N
Sbjct: 146 RLQNETAAN 154
>XP_005265662
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           RLQ ETA N
Sbjct: 146 RLQNETAAN 154
>NP_001239
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RLQFETADN 9
           RLQ ETA N
Sbjct: 146 RLQNETAAN 154
>NP_149347
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+Q +TA+N
Sbjct: 136 RMQNDTAEN 144
>NP_004333
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+Q +TA+N
Sbjct: 136 RMQNDTAEN 144
>NP_149130
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+Q +TA+N
Sbjct: 130 RMQNDTAEN 138
>NP_149129
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+Q +TA+N
Sbjct: 136 RMQNDTAEN 144
>NP_149131
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+Q +TA+N
Sbjct: 130 RMQNDTAEN 138
>NP_001265455
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  QFETADN 9
          +FET DN
Sbjct: 39 KFETRDN 45
>NP_071400
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   FETADN 9
           FET DN
Sbjct: 462 FETTDN 467
>NP_001265454
          Length = 1483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QFETADN 9
           +FET DN
Sbjct: 569 KFETRDN 575
>NP_001265453
          Length = 1483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QFETADN 9
           +FET DN
Sbjct: 569 KFETRDN 575
>NP_055641
          Length = 1638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QFETADN 9
           QFET D+
Sbjct: 885 QFETVDS 891
>NP_055618
          Length = 1483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QFETADN 9
           +FET DN
Sbjct: 569 KFETRDN 575
>NP_001095841
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FETADN 9
           FETA+N
Sbjct: 226 FETAEN 231
>NP_079231
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FETADN 9
           FETA+N
Sbjct: 226 FETAEN 231
>NP_003598
          Length = 1719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QFETADN 9
           QFET D+
Sbjct: 966 QFETVDS 972
>XP_006724655
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   FETADN 9
           FET DN
Sbjct: 462 FETTDN 467
>XP_006724383
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FETADN 9
           FETA+N
Sbjct: 226 FETAEN 231
>XP_006716202
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+Q +TA+N
Sbjct: 136 RMQNDTAEN 144
>XP_006716201
          Length = 767

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+Q +TA+N
Sbjct: 136 RMQNDTAEN 144
>XP_006716200
          Length = 787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+Q +TA+N
Sbjct: 130 RMQNDTAEN 138
>XP_006716199
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RLQFETADN 9
           R+Q +TA+N
Sbjct: 136 RMQNDTAEN 144
>XP_005273378
          Length = 1781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QFETADN 9
           QFET D+
Sbjct: 966 QFETVDS 972
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.129    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 433,977
Number of extensions: 716
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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