Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002040                                                              18    1482
NP_058644                                                              16    7355
NP_116020                                                              16    7355
XP_006721256                                                           16    7355
NP_001001520                                                           16    7355
NP_005493                                                              15    9605
NP_899229                                                              15    9605
NP_005119                                                              15    9605
XP_006724131                                                           15    9605
XP_005251837                                                           15    9605
XP_005251835                                                           15    9605
XP_006717058                                                           15    9605
XP_005251833                                                           15    9605
XP_005251831                                                           15    9605
XP_005251830                                                           15    9605
XP_005246847                                                           15    9605
XP_006712769                                                           15    9605
XP_006712768                                                           15    9605
XP_006712767                                                           15    9605
XP_006712766                                                           15    9605
XP_005246846                                                           15    9605
NP_005061                                                              15    9605
NP_004875                                                              15    9605
NP_963868                                                              15    9605
>NP_002040
          Length = 413

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RLIVSKRA 8
           RLIVSKRA
Sbjct: 247 RLIVSKRA 254
>NP_058644
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RLIVSKRA 8
          RL+V KRA
Sbjct: 89 RLLVQKRA 96
>NP_116020
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RLIVSKRAR 9
           ++ VSKRAR
Sbjct: 163 KMSVSKRAR 171
>XP_006721256
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RLIVSKRA 8
          RL+V KRA
Sbjct: 85 RLLVQKRA 92
>NP_001001520
          Length = 671

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RLIVSKRAR 9
           ++ VSKRAR
Sbjct: 163 KMSVSKRAR 171
>NP_005493
          Length = 2261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    RLIVSKRAR 9
            RL++++R+R
Sbjct: 1336 RLLIARRSR 1344
>NP_899229
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RLIVSKR 7
          RLIVS+R
Sbjct: 26 RLIVSRR 32
>NP_005119
          Length = 2298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RLIVSKR 7
          RL++SKR
Sbjct: 60 RLLISKR 66
>XP_006724131
          Length = 2298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RLIVSKR 7
          RL++SKR
Sbjct: 60 RLLISKR 66
>XP_005251837
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    RLIVSKRAR 9
            RL++++R+R
Sbjct: 1338 RLLIARRSR 1346
>XP_005251835
          Length = 2074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    RLIVSKRAR 9
            RL++++R+R
Sbjct: 1338 RLLIARRSR 1346
>XP_006717058
          Length = 2100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    RLIVSKRAR 9
            RL++++R+R
Sbjct: 1338 RLLIARRSR 1346
>XP_005251833
          Length = 2203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    RLIVSKRAR 9
            RL++++R+R
Sbjct: 1278 RLLIARRSR 1286
>XP_005251831
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    RLIVSKRAR 9
            RL++++R+R
Sbjct: 1338 RLLIARRSR 1346
>XP_005251830
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    RLIVSKRAR 9
            RL++++R+R
Sbjct: 1338 RLLIARRSR 1346
>XP_005246847
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LIVSKRAR 9
           LIVS++AR
Sbjct: 811 LIVSQKAR 818
>XP_006712769
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LIVSKRAR 9
           LIVS++AR
Sbjct: 836 LIVSQKAR 843
>XP_006712768
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LIVSKRAR 9
           LIVS++AR
Sbjct: 927 LIVSQKAR 934
>XP_006712767
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LIVSKRAR 9
           LIVS++AR
Sbjct: 927 LIVSQKAR 934
>XP_006712766
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LIVSKRAR 9
           LIVS++AR
Sbjct: 956 LIVSQKAR 963
>XP_005246846
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LIVSKRAR 9
            LIVS++AR
Sbjct: 1036 LIVSQKAR 1043
>NP_005061
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LIVSKRAR 9
            LIVS++AR
Sbjct: 1009 LIVSQKAR 1016
>NP_004875
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LIVSKRAR 9
           L+VS++AR
Sbjct: 125 LVVSRKAR 132
>NP_963868
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LIVSKRAR 9
            LIVS++AR
Sbjct: 1036 LIVSQKAR 1043
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.142    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 297,829
Number of extensions: 322
Number of successful extensions: 24
Number of sequences better than 10000.0: 24
Number of HSP's gapped: 24
Number of HSP's successfully gapped: 24
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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