Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001035829                                                           17    4312
NP_001166996                                                           17    4312
NP_004591                                                              17    4312
NP_001166995                                                           17    4312
NP_001035828                                                           17    4312
NP_665879                                                              17    4312
XP_006721650                                                           17    4312
XP_006711560                                                           17    4312
XP_006711559                                                           17    4312
XP_006711558                                                           17    4312
NP_003546                                                              17    4312
NP_000273                                                              16    5631
NP_001171475                                                           16    5631
NP_001244960                                                           16    5631
XP_005254116                                                           16    5631
NP_060426                                                              16    7355
NP_444253                                                              15    9605
NP_444255                                                              15    9605
NP_005148                                                              15    9605
NP_055756                                                              15    9605
NP_009297                                                              15    9605
NP_060587                                                              15    9605
NP_001264214                                                           15    9605
NP_055646                                                              15    9605
XP_005261449                                                           15    9605
XP_005261448                                                           15    9605
XP_006718858                                                           15    9605
XP_005270021                                                           15    9605
XP_005270020                                                           15    9605
XP_005270019                                                           15    9605
XP_005247550                                                           15    9605
XP_006713712                                                           15    9605
XP_005247549                                                           15    9605
XP_006713495                                                           15    9605
NP_001139669                                                           15    9605
NP_795370                                                              15    9605
>NP_001035829
          Length = 534

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LCLIVSRT 9
           +C++V+RT
Sbjct: 399 MCMVVTRT 406
>NP_001166996
          Length = 518

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LCLIVSRT 9
           +C++V+RT
Sbjct: 399 MCMVVTRT 406
>NP_004591
          Length = 538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LCLIVSRT 9
           +C++V+RT
Sbjct: 399 MCMVVTRT 406
>NP_001166995
          Length = 538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LCLIVSRT 9
           +C++V+RT
Sbjct: 399 MCMVVTRT 406
>NP_001035828
          Length = 525

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LCLIVSRT 9
           +C++V+RT
Sbjct: 399 MCMVVTRT 406
>NP_665879
          Length = 349

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RLCLIVSR 8
           RLC +VSR
Sbjct: 328 RLCPVVSR 335
>XP_006721650
          Length = 313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LCLIVSRT 9
           LCLI+S T
Sbjct: 212 LCLIISYT 219
>XP_006711560
          Length = 538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LCLIVSRT 9
           +C++V+RT
Sbjct: 399 MCMVVTRT 406
>XP_006711559
          Length = 560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LCLIVSRT 9
           +C++V+RT
Sbjct: 421 MCMVVTRT 428
>XP_006711558
          Length = 560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LCLIVSRT 9
           +C++V+RT
Sbjct: 421 MCMVVTRT 428
>NP_003546
          Length = 313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LCLIVSRT 9
           LCLI+S T
Sbjct: 212 LCLIISYT 219
>NP_000273
          Length = 728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RLCLIVSR 8
          R CL+VSR
Sbjct: 42 RQCLMVSR 49
>NP_001171475
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RLCLIVSR 8
          R CL+VSR
Sbjct: 42 RQCLMVSR 49
>NP_001244960
          Length = 518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  CLIVSRT 9
          CL++SRT
Sbjct: 76 CLLLSRT 82
>XP_005254116
          Length = 640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RLCLIVSR 8
          R CL+VSR
Sbjct: 42 RQCLMVSR 49
>NP_060426
          Length = 448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RLCLIVSR 8
           +LCL VSR
Sbjct: 106 KLCLEVSR 113
>NP_444253
          Length = 1914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LCLIVSRT 9
           LCL+ +RT
Sbjct: 472 LCLLKART 479
>NP_444255
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LCLIVSRT 9
           LCL+ +RT
Sbjct: 472 LCLLKART 479
>NP_005148
          Length = 1130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    LCLIVSR 8
            LCL +SR
Sbjct: 1039 LCLAISR 1045
>NP_055756
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  CLIVSRT 9
          CL +SRT
Sbjct: 65 CLFLSRT 71
>NP_009297
          Length = 1149

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    LCLIVSR 8
            LCL +SR
Sbjct: 1058 LCLAISR 1064
>NP_060587
          Length = 1224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CLIVSR 8
           CL+VSR
Sbjct: 913 CLLVSR 918
>NP_001264214
          Length = 1437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CLIVSRT 9
           CLI +RT
Sbjct: 620 CLIANRT 626
>NP_055646
          Length = 2925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    RLCLIVS 7
            R CL+VS
Sbjct: 2681 RACLVVS 2687
>XP_005261449
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CLIVSRT 9
           CL +SRT
Sbjct: 127 CLFLSRT 133
>XP_005261448
          Length = 1032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CLIVSRT 9
           CL +SRT
Sbjct: 127 CLFLSRT 133
>XP_006718858
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CLIVSRT 9
           CLI +RT
Sbjct: 96  CLIANRT 102
>XP_005270021
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CLIVSR 8
           CL+VSR
Sbjct: 442 CLLVSR 447
>XP_005270020
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CLIVSR 8
           CL+VSR
Sbjct: 654 CLLVSR 659
>XP_005270019
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CLIVSR 8
           CL+VSR
Sbjct: 654 CLLVSR 659
>XP_005247550
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LCLIVSRT 9
           LCL+ +RT
Sbjct: 482 LCLLKART 489
>XP_006713712
          Length = 1923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LCLIVSRT 9
           LCL+ +RT
Sbjct: 482 LCLLKART 489
>XP_005247549
          Length = 1924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LCLIVSRT 9
           LCL+ +RT
Sbjct: 482 LCLLKART 489
>XP_006713495
          Length = 2969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    RLCLIVS 7
            R CL+VS
Sbjct: 2725 RACLVVS 2731
>NP_001139669
          Length = 7081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    CLIVSRT 9
            C+++SRT
Sbjct: 5546 CVVLSRT 5552
>NP_795370
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LCLIVS 7
           LCLI+S
Sbjct: 243 LCLIIS 248
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.346    0.147    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 519,666
Number of extensions: 622
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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