Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718908                                                           20     509
XP_005271621                                                           20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_001070650                                                           17    2528
NP_036550                                                              17    2528
NP_443132                                                              17    2528
NP_937757                                                              17    2528
NP_937756                                                              17    2528
XP_005257253                                                           17    2528
XP_005257252                                                           17    2528
NP_057715                                                              16    5631
NP_037461                                                              16    5631
NP_073616                                                              16    5631
XP_006724130                                                           16    5631
XP_006724129                                                           16    5631
XP_006717299                                                           16    5631
XP_005272265                                                           16    5631
XP_005272264                                                           16    5631
XP_005272263                                                           16    5631
NP_619526                                                              16    5631
NP_116196                                                              16    7355
NP_835363                                                              16    7355
NP_001245381                                                           16    7355
NP_001245382                                                           16    7355
NP_001138766                                                           16    7355
NP_001138767                                                           16    7355
NP_060767                                                              16    7355
NP_001138765                                                           16    7355
NP_003120                                                              16    7355
XP_006717580                                                           16    7355
XP_006717579                                                           16    7355
XP_005265374                                                           16    7355
XP_005265373                                                           16    7355
NP_003822                                                              16    7355
NP_002931                                                              16    7355
NP_001035809                                                           16    7355
NP_001278340                                                           15    9605
NP_620305                                                              15    9605
NP_001230111                                                           15    9605
NP_000044                                                              15    9605
NP_001005918                                                           15    9605
NP_001230217                                                           15    9605
NP_115571                                                              15    9605
NP_001177396                                                           15    9605
NP_056540                                                              15    9605
NP_114141                                                              15    9605
NP_056295                                                              15    9605
NP_001230215                                                           15    9605
NP_001681                                                              15    9605
XP_006724107                                                           15    9605
XP_006724106                                                           15    9605
XP_005266488                                                           15    9605
XP_006719902                                                           15    9605
XP_006719901                                                           15    9605
XP_005266489                                                           15    9605
XP_005266487                                                           15    9605
XP_005266486                                                           15    9605
XP_005266485                                                           15    9605
XP_005266484                                                           15    9605
XP_006719900                                                           15    9605
XP_005266480                                                           15    9605
XP_005266481                                                           15    9605
XP_005268766                                                           15    9605
XP_005247379                                                           15    9605
XP_005247378                                                           15    9605
NP_001408                                                              15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKGINISAD 9
            RKGINI AD
Sbjct: 2642 RKGINIPAD 2650
>XP_006718908
          Length = 1708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKGINISAD 9
            RKGINI AD
Sbjct: 1294 RKGINIPAD 1302
>XP_005271621
          Length = 2708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKGINISAD 9
            RKGINI AD
Sbjct: 2294 RKGINIPAD 2302
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKGINISAD 9
            RKGINI AD
Sbjct: 2636 RKGINIPAD 2644
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKGINISAD 9
            RKGINI AD
Sbjct: 2642 RKGINIPAD 2650
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKGINISAD 9
            RKGINI AD
Sbjct: 2642 RKGINIPAD 2650
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKGINISAD 9
            RKGINI AD
Sbjct: 2642 RKGINIPAD 2650
>NP_001070650
          Length = 516

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RKGINISAD 9
           R+G+N+SA+
Sbjct: 274 RQGVNVSAN 282
>NP_036550
          Length = 492

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RKGINISAD 9
           R+G+N+SA+
Sbjct: 274 RQGVNVSAN 282
>NP_443132
          Length = 3538

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KGINISA 8
            KGINISA
Sbjct: 1173 KGINISA 1179
>NP_937757
          Length = 3667

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KGINISA 8
            KGINISA
Sbjct: 1237 KGINISA 1243
>NP_937756
          Length = 3707

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    KGINISA 8
            KGINISA
Sbjct: 1277 KGINISA 1283
>XP_005257253
          Length = 492

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RKGINISAD 9
           R+G+N+SA+
Sbjct: 274 RQGVNVSAN 282
>XP_005257252
          Length = 516

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RKGINISAD 9
           R+G+N+SA+
Sbjct: 274 RQGVNVSAN 282
>NP_057715
          Length = 917

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 318 RKGINI 323
>NP_037461
          Length = 815

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 318 RKGINI 323
>NP_073616
          Length = 851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 354 RKGINI 359
>XP_006724130
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 318 RKGINI 323
>XP_006724129
          Length = 882

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 318 RKGINI 323
>XP_006717299
          Length = 691

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 354 RKGINI 359
>XP_005272265
          Length = 722

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 225 RKGINI 230
>XP_005272264
          Length = 755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 258 RKGINI 263
>XP_005272263
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 354 RKGINI 359
>NP_619526
          Length = 585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RKGINI 6
           RKGINI
Sbjct: 354 RKGINI 359
>NP_116196
          Length = 1094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 448 KGINIS 453
>NP_835363
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 397 KGINIS 402
>NP_001245381
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 323 KGINIS 328
>NP_001245382
          Length = 969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 323 KGINIS 328
>NP_001138766
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 177 KGINIS 182
>NP_001138767
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 219 KGINIS 224
>NP_060767
          Length = 654

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 219 KGINIS 224
>NP_001138765
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 219 KGINIS 224
>NP_003120
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RKGINIS 7
           RKG NIS
Sbjct: 99  RKGTNIS 105
>XP_006717580
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 397 KGINIS 402
>XP_006717579
          Length = 1180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 534 KGINIS 539
>XP_005265374
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 219 KGINIS 224
>XP_005265373
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KGINIS 7
           KGINIS
Sbjct: 219 KGINIS 224
>NP_003822
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GINISAD 9
           G+NI+AD
Sbjct: 470 GLNITAD 476
>NP_002931
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           R+GINI  D
Sbjct: 306 REGINIFLD 314
>NP_001035809
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           R+GINI  D
Sbjct: 306 REGINIFLD 314
>NP_001278340
          Length = 2108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KGINISA 8
            KGIN+S+
Sbjct: 1485 KGINLSS 1491
>NP_620305
          Length = 2426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KGINISA 8
            KGIN+S+
Sbjct: 1485 KGINLSS 1491
>NP_001230111
          Length = 1354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1045 RNGLTISSD 1053
>NP_000044
          Length = 1465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1156 RNGLTISSD 1164
>NP_001005918
          Length = 1258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           R G+ IS+D
Sbjct: 949 RNGLTISSD 957
>NP_001230217
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           RKG+N+  +
Sbjct: 261 RKGVNLKCN 269
>NP_115571
          Length = 2303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KGINISA 8
            KGIN+S+
Sbjct: 1485 KGINLSS 1491
>NP_001177396
          Length = 1346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RKGINISAD 9
           +KG+ ISA+
Sbjct: 131 QKGLRISAE 139
>NP_056540
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RKGINISA 8
          R+GIN++A
Sbjct: 16 REGINMAA 23
>NP_114141
          Length = 5635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KGINISAD 9
            KG+ I+AD
Sbjct: 5134 KGLTIAAD 5141
>NP_056295
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           RKG+N+  +
Sbjct: 284 RKGVNLKCN 292
>NP_001230215
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           RKG+N+  +
Sbjct: 284 RKGVNLKCN 292
>NP_001681
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KGINISA 8
           +G+N+SA
Sbjct: 120 RGVNVSA 126
>XP_006724107
          Length = 2298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KGINISA 8
            KGIN+S+
Sbjct: 1485 KGINLSS 1491
>XP_006724106
          Length = 2459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KGINISA 8
            KGIN+S+
Sbjct: 1485 KGINLSS 1491
>XP_005266488
          Length = 1453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1144 RNGLTISSD 1152
>XP_006719902
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           R G+ IS+D
Sbjct: 367 RNGLTISSD 375
>XP_006719901
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           R G+ IS+D
Sbjct: 428 RNGLTISSD 436
>XP_005266489
          Length = 1303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 994  RNGLTISSD 1002
>XP_005266487
          Length = 1465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1156 RNGLTISSD 1164
>XP_005266486
          Length = 1355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1046 RNGLTISSD 1054
>XP_005266485
          Length = 1381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1072 RNGLTISSD 1080
>XP_005266484
          Length = 1387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1078 RNGLTISSD 1086
>XP_006719900
          Length = 1433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1124 RNGLTISSD 1132
>XP_005266480
          Length = 1433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1124 RNGLTISSD 1132
>XP_005266481
          Length = 1433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RKGINISAD 9
            R G+ IS+D
Sbjct: 1124 RNGLTISSD 1132
>XP_005268766
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KGINISA 8
           +G+NISA
Sbjct: 117 RGLNISA 123
>XP_005247379
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           RKG+N+  +
Sbjct: 284 RKGVNLKCN 292
>XP_005247378
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RKGINISAD 9
           RKG+N+  +
Sbjct: 261 RKGVNLKCN 269
>NP_001408
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KGINISA 8
           +G+NISA
Sbjct: 117 RGLNISA 123
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.134    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,814
Number of extensions: 656
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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