Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
NP_006022                                                              19     869
XP_005261186                                                           19     869
XP_005261185                                                           19     869
XP_005261184                                                           19     869
XP_005261183                                                           19     869
XP_005261182                                                           19     869
XP_005261181                                                           19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
XP_005255877                                                           17    3301
XP_005255876                                                           17    3301
XP_005255874                                                           17    3301
XP_006721218                                                           17    3301
XP_005255872                                                           17    3301
NP_710155                                                              17    3301
NP_000101                                                              17    4312
NP_002171                                                              17    4312
NP_001019846                                                           17    4312
XP_005274034                                                           17    4312
XP_005274033                                                           17    4312
XP_006710460                                                           17    4312
XP_005270619                                                           17    4312
NP_201570                                                              16    5631
NP_201569                                                              16    5631
NP_003663                                                              16    5631
XP_005271353                                                           16    5631
XP_005271351                                                           16    5631
NP_660186                                                              16    7355
NP_056166                                                              16    7355
NP_002895                                                              16    7355
XP_006726188                                                           16    7355
XP_006726100                                                           16    7355
XP_006725999                                                           16    7355
XP_006725802                                                           16    7355
XP_006725584                                                           16    7355
XP_005272547                                                           16    7355
XP_005272546                                                           16    7355
XP_006722863                                                           16    7355
XP_006715268                                                           16    7355
NP_003165                                                              15    9605
NP_068506                                                              15    9605
NP_599151                                                              15    9605
NP_599150                                                              15    9605
XP_005269179                                                           15    9605
XP_005269177                                                           15    9605
XP_006719644                                                           15    9605
XP_005269173                                                           15    9605
XP_005269172                                                           15    9605
XP_005269171                                                           15    9605
XP_006717559                                                           15    9605
XP_006717558                                                           15    9605
XP_006717557                                                           15    9605
XP_006717556                                                           15    9605
XP_005252630                                                           15    9605
XP_005252629                                                           15    9605
XP_005252628                                                           15    9605
XP_005252627                                                           15    9605
XP_005252626                                                           15    9605
XP_005252625                                                           15    9605
XP_005252624                                                           15    9605
XP_005252623                                                           15    9605
XP_005252622                                                           15    9605
XP_006717555                                                           15    9605
XP_005252621                                                           15    9605
NP_004169                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3712 RKALIYQKK 3720
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3704 RKALIYQKK 3712
>NP_006022
          Length = 3336

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3146 RKALIYQKK 3154
>XP_005261186
          Length = 3139

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 2949 RKALIYQKK 2957
>XP_005261185
          Length = 3229

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3039 RKALIYQKK 3047
>XP_005261184
          Length = 3258

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3157 RKALIYQKK 3165
>XP_005261183
          Length = 3268

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3078 RKALIYQKK 3086
>XP_005261182
          Length = 3346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3156 RKALIYQKK 3164
>XP_005261181
          Length = 3347

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3157 RKALIYQKK 3165
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3665 RKALIYQKK 3673
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3744 RKALIYQKK 3752
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RKALIYLKK 9
            RKALIY KK
Sbjct: 3757 RKALIYQKK 3765
>XP_005255877
          Length = 352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KALIYLKK 9
          KAL+YLK+
Sbjct: 84 KALLYLKQ 91
>XP_005255876
          Length = 352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KALIYLKK 9
          KAL+YLK+
Sbjct: 84 KALLYLKQ 91
>XP_005255874
          Length = 407

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KALIYLKK 9
           KAL+YLK+
Sbjct: 139 KALLYLKQ 146
>XP_006721218
          Length = 407

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KALIYLKK 9
           KAL+YLK+
Sbjct: 139 KALLYLKQ 146
>XP_005255872
          Length = 430

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KALIYLKK 9
           KAL+YLK+
Sbjct: 162 KALLYLKQ 169
>NP_710155
          Length = 407

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KALIYLKK 9
           KAL+YLK+
Sbjct: 139 KALLYLKQ 146
>NP_000101
          Length = 1025

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALIYLK 8
           KAL+YLK
Sbjct: 835 KALLYLK 841
>NP_002171
          Length = 993

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RKALIYLKK 9
           +KALI LKK
Sbjct: 149 KKALIALKK 157
>NP_001019846
          Length = 245

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RKALIYLKK 9
          RKA+ +LKK
Sbjct: 74 RKAITHLKK 82
>XP_005274034
          Length = 508

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RKALIYLKK 9
           +KALI LKK
Sbjct: 149 KKALIALKK 157
>XP_005274033
          Length = 540

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RKALIYLKK 9
           +KALI LKK
Sbjct: 149 KKALIALKK 157
>XP_006710460
          Length = 889

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALIYLK 8
           KAL+YLK
Sbjct: 835 KALLYLK 841
>XP_005270619
          Length = 953

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KALIYLK 8
           KAL+YLK
Sbjct: 763 KALLYLK 769
>NP_201570
          Length = 383

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ALIYLKK 9
           A+IYLKK
Sbjct: 103 AVIYLKK 109
>NP_201569
          Length = 623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ALIYLKK 9
           A+IYLKK
Sbjct: 103 AVIYLKK 109
>NP_003663
          Length = 594

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ALIYLKK 9
           A+IYLKK
Sbjct: 103 AVIYLKK 109
>XP_005271353
          Length = 595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ALIYLKK 9
           A+IYLKK
Sbjct: 104 AVIYLKK 110
>XP_005271351
          Length = 624

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ALIYLKK 9
           A+IYLKK
Sbjct: 104 AVIYLKK 110
>NP_660186
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KALIYLKK 9
           KAL YLK+
Sbjct: 228 KALYYLKE 235
>NP_056166
          Length = 222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KALIYLKK 9
           KAL YLK+
Sbjct: 182 KALYYLKE 189
>NP_002895
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RKALIYLKK 9
          +KAL+ LKK
Sbjct: 26 KKALLALKK 34
>XP_006726188
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RKALIYLKK 9
          +KAL+ LKK
Sbjct: 26 KKALLALKK 34
>XP_006726100
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RKALIYLKK 9
          +KAL+ LKK
Sbjct: 26 KKALLALKK 34
>XP_006725999
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RKALIYLKK 9
          +KAL+ LKK
Sbjct: 26 KKALLALKK 34
>XP_006725802
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RKALIYLKK 9
          +KAL+ LKK
Sbjct: 26 KKALLALKK 34
>XP_006725584
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RKALIYLKK 9
          +KAL+ LKK
Sbjct: 26 KKALLALKK 34
>XP_005272547
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KALIYLKK 9
           KAL YLK+
Sbjct: 228 KALYYLKE 235
>XP_005272546
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KALIYLKK 9
           KAL YLK+
Sbjct: 244 KALYYLKE 251
>XP_006722863
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KALIYLKK 9
           KAL YLK+
Sbjct: 244 KALYYLKE 251
>XP_006715268
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RKALIYLKK 9
          +KAL+ LKK
Sbjct: 26 KKALLALKK 34
>NP_003165
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1493 KALIYL 1498
>NP_068506
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1919 KALIYL 1924
>NP_599151
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALIYLK 8
           R+AL YLK
Sbjct: 332 RRALQYLK 339
>NP_599150
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALIYLK 8
           R+AL YLK
Sbjct: 353 RRALQYLK 360
>XP_005269179
          Length = 222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALIYLK 8
           R+AL YLK
Sbjct: 209 RRALQYLK 216
>XP_005269177
          Length = 222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALIYLK 8
           R+AL YLK
Sbjct: 209 RRALQYLK 216
>XP_006719644
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALIYLK 8
           R+AL YLK
Sbjct: 254 RRALQYLK 261
>XP_005269173
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALIYLK 8
           R+AL YLK
Sbjct: 313 RRALQYLK 320
>XP_005269172
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALIYLK 8
           R+AL YLK
Sbjct: 332 RRALQYLK 339
>XP_005269171
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALIYLK 8
           R+AL YLK
Sbjct: 332 RRALQYLK 339
>XP_006717559
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1571 KALIYL 1576
>XP_006717558
          Length = 1908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1613 KALIYL 1618
>XP_006717557
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1645 KALIYL 1650
>XP_006717556
          Length = 2024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1729 KALIYL 1734
>XP_005252630
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1961 KALIYL 1966
>XP_005252629
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1961 KALIYL 1966
>XP_005252628
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1961 KALIYL 1966
>XP_005252627
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1961 KALIYL 1966
>XP_005252626
          Length = 2260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1965 KALIYL 1970
>XP_005252625
          Length = 2277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1982 KALIYL 1987
>XP_005252624
          Length = 2292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 1997 KALIYL 2002
>XP_005252623
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 2007 KALIYL 2012
>XP_005252622
          Length = 2308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 2013 KALIYL 2018
>XP_006717555
          Length = 2328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 2033 KALIYL 2038
>XP_005252621
          Length = 2334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    KALIYL 7
            KALIYL
Sbjct: 2039 KALIYL 2044
>NP_004169
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RKALIYLK 8
           R+AL YLK
Sbjct: 332 RRALQYLK 339
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.145    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 406,893
Number of extensions: 681
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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