Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138389                                                           18    1482
NP_001138390                                                           18    1482
NP_001138386                                                           18    1482
NP_001138387                                                           18    1482
NP_000132                                                              18    1482
NP_075259                                                              18    1482
NP_001138388                                                           18    1482
NP_001138391                                                           18    1482
NP_001138385                                                           18    1482
NP_075418                                                              18    1482
XP_006717776                                                           18    1482
XP_006717775                                                           18    1482
XP_006717774                                                           18    1482
XP_006717773                                                           18    1482
XP_006717772                                                           18    1482
XP_006717771                                                           18    1482
NP_004384                                                              17    3301
NP_001171110                                                           17    3301
NP_001171113                                                           17    3301
NP_001171114                                                           17    3301
NP_001159400                                                           17    3301
NP_001171111                                                           17    3301
NP_001171112                                                           17    3301
NP_001171115                                                           17    3301
NP_001171107                                                           17    3301
NP_001171105                                                           17    3301
NP_001171106                                                           17    3301
NP_001171109                                                           17    3301
NP_001171108                                                           17    3301
NP_036605                                                              16    5631
NP_001092313                                                           16    5631
XP_006724289                                                           16    5631
XP_005261565                                                           16    5631
NP_078926                                                              16    7355
NP_056073                                                              15    9605
XP_006717418                                                           15    9605
XP_006717082                                                           15    9605
XP_006717081                                                           15    9605
>NP_001138389
          Length = 705

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 330 RITTRLSST 338
>NP_001138390
          Length = 704

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 329 RITTRLSST 337
>NP_001138386
          Length = 709

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 334 RITTRLSST 342
>NP_001138387
          Length = 707

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 357 RITTRLSST 365
>NP_000132
          Length = 821

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 446 RITTRLSST 454
>NP_075259
          Length = 822

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 447 RITTRLSST 455
>NP_001138388
          Length = 706

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 331 RITTRLSST 339
>NP_001138391
          Length = 680

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 358 RITTRLSST 366
>NP_001138385
          Length = 769

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 447 RITTRLSST 455
>NP_075418
          Length = 732

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 357 RITTRLSST 365
>XP_006717776
          Length = 806

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 465 RITTRLSST 473
>XP_006717775
          Length = 726

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 351 RITTRLSST 359
>XP_006717774
          Length = 752

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 377 RITTRLSST 385
>XP_006717773
          Length = 807

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 466 RITTRLSST 474
>XP_006717772
          Length = 838

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 463 RITTRLSST 471
>XP_006717771
          Length = 839

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RITTRLSLT 9
           RITTRLS T
Sbjct: 464 RITTRLSST 472
>NP_004384
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171110
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171113
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171114
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001159400
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171111
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171112
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171115
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171107
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171105
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171106
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171109
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_001171108
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RITTRLSLT 9
           R+TT++S+T
Sbjct: 461 RVTTKVSIT 469
>NP_036605
          Length = 166

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TTRLSLT 9
          TTR+SLT
Sbjct: 54 TTRISLT 60
>NP_001092313
          Length = 633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RITTRLSL 8
           RITTR+ L
Sbjct: 197 RITTRIGL 204
>XP_006724289
          Length = 166

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TTRLSLT 9
          TTR+SLT
Sbjct: 54 TTRISLT 60
>XP_005261565
          Length = 197

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TTRLSLT 9
          TTR+SLT
Sbjct: 85 TTRISLT 91
>NP_078926
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ITTRLSLT 9
           +TTR SLT
Sbjct: 103 VTTRWSLT 110
>NP_056073
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TTRLSLT 9
            +TRLSLT
Sbjct: 1093 STRLSLT 1099
>XP_006717418
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ITTRLSL 8
          ITTRLS+
Sbjct: 36 ITTRLSV 42

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ITTRLSL 8
          ITTRLS+
Sbjct: 43 ITTRLSV 49

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ITTRLSL 8
           ITTRLS+
Sbjct: 101 ITTRLSV 107

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ITTRLSL 8
           ITTRLS+
Sbjct: 166 ITTRLSV 172
>XP_006717082
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TTRLSLT 9
            +TRLSLT
Sbjct: 1025 STRLSLT 1031
>XP_006717081
          Length = 1209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TTRLSLT 9
            +TRLSLT
Sbjct: 1083 STRLSLT 1089
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.132    0.322 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 242,626
Number of extensions: 286
Number of successful extensions: 41
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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