Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718908                                                           20     509
XP_005271621                                                           20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_078813                                                              17    3301
XP_006720016                                                           17    3301
NP_000050                                                              17    4312
NP_055319                                                              17    4312
NP_001273990                                                           17    4312
NP_001273991                                                           17    4312
NP_001273989                                                           17    4312
NP_071933                                                              16    5631
NP_001265641                                                           16    5631
XP_006726514                                                           16    5631
XP_003846779                                                           16    5631
NP_056289                                                              16    7355
NP_878918                                                              16    7355
NP_055995                                                              16    7355
NP_001172087                                                           16    7355
NP_112497                                                              16    7355
NP_001229468                                                           16    7355
NP_054790                                                              16    7355
NP_689484                                                              16    7355
NP_001159438                                                           16    7355
XP_006723818                                                           16    7355
XP_006723817                                                           16    7355
XP_006723816                                                           16    7355
XP_006723815                                                           16    7355
XP_006723814                                                           16    7355
XP_006723813                                                           16    7355
XP_005260405                                                           16    7355
XP_006721645                                                           16    7355
XP_006720147                                                           16    7355
XP_005267517                                                           16    7355
XP_005267516                                                           16    7355
XP_005267515                                                           16    7355
XP_005267514                                                           16    7355
XP_005267513                                                           16    7355
XP_005267512                                                           16    7355
XP_005267511                                                           16    7355
XP_005273742                                                           16    7355
NP_001127854                                                           15    9605
NP_055684                                                              15    9605
NP_037452                                                              15    9605
NP_060350                                                              15    9605
NP_000695                                                              15    9605
NP_065764                                                              15    9605
XP_005260283                                                           15    9605
XP_005264448                                                           15    9605
XP_005264447                                                           15    9605
XP_005264446                                                           15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIRITKNVP 9
            R RITKNVP
Sbjct: 2580 RSRITKNVP 2588
>XP_006718908
          Length = 1708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIRITKNVP 9
            R RITKNVP
Sbjct: 1232 RSRITKNVP 1240
>XP_005271621
          Length = 2708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIRITKNVP 9
            R RITKNVP
Sbjct: 2232 RSRITKNVP 2240
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIRITKNVP 9
            R RITKNVP
Sbjct: 2574 RSRITKNVP 2582
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIRITKNVP 9
            R RITKNVP
Sbjct: 2580 RSRITKNVP 2588
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIRITKNVP 9
            R RITKNVP
Sbjct: 2580 RSRITKNVP 2588
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIRITKNVP 9
            R RITKNVP
Sbjct: 2580 RSRITKNVP 2588
>NP_078813
          Length = 564

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IRITKNVP 9
           +R+T+N+P
Sbjct: 163 LRVTENIP 170
>XP_006720016
          Length = 451

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  IRITKNVP 9
          +R+T+N+P
Sbjct: 50 LRVTENIP 57
>NP_000050
          Length = 3418

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           + +TKN+P
Sbjct: 807 VELTKNIP 814
>NP_055319
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           I+ITKN P
Sbjct: 302 IKITKNEP 309
>NP_001273990
          Length = 505

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           I+ITKN P
Sbjct: 316 IKITKNEP 323
>NP_001273991
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           I+ITKN P
Sbjct: 302 IKITKNEP 309
>NP_001273989
          Length = 299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           I+ITKN P
Sbjct: 110 IKITKNEP 117
>NP_071933
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  ITKNVP 9
          +TKNVP
Sbjct: 75 VTKNVP 80
>NP_001265641
          Length = 311

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  ITKNVP 9
          +TKNVP
Sbjct: 75 VTKNVP 80
>XP_006726514
          Length = 1038

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +RIT+N P
Sbjct: 515 LRITENTP 522
>XP_003846779
          Length = 914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +RIT+N P
Sbjct: 449 LRITENTP 456
>NP_056289
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IRITKN 7
           IRITKN
Sbjct: 530 IRITKN 535
>NP_878918
          Length = 6907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>NP_055995
          Length = 6885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>NP_001172087
          Length = 63

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RIRITKNVP 9
          ++RIT  VP
Sbjct: 16 KLRITSRVP 24
>NP_112497
          Length = 974

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RITKNVP 9
           RIT NVP
Sbjct: 696 RITYNVP 702
>NP_001229468
          Length = 1070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +R+T N+P
Sbjct: 94  VRVTFNIP 101
>NP_054790
          Length = 2063

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +R+T N+P
Sbjct: 94  VRVTFNIP 101
>NP_689484
          Length = 773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ITKNVP 9
           +TKNVP
Sbjct: 564 LTKNVP 569
>NP_001159438
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RITKNVP 9
           RIT NVP
Sbjct: 660 RITYNVP 666
>XP_006723818
          Length = 1975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +R+T N+P
Sbjct: 94  VRVTFNIP 101
>XP_006723817
          Length = 2020

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +R+T N+P
Sbjct: 94  VRVTFNIP 101
>XP_006723816
          Length = 2034

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +R+T N+P
Sbjct: 94  VRVTFNIP 101
>XP_006723815
          Length = 2051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +R+T N+P
Sbjct: 94  VRVTFNIP 101
>XP_006723814
          Length = 2052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +R+T N+P
Sbjct: 94  VRVTFNIP 101
>XP_006723813
          Length = 2062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +R+T N+P
Sbjct: 94  VRVTFNIP 101
>XP_005260405
          Length = 2063

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           +R+T N+P
Sbjct: 94  VRVTFNIP 101
>XP_006721645
          Length = 933

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RITKNVP 9
           RIT NVP
Sbjct: 655 RITYNVP 661
>XP_006720147
          Length = 4788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>XP_005267517
          Length = 6883

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>XP_005267516
          Length = 6884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>XP_005267515
          Length = 6899

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>XP_005267514
          Length = 6908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>XP_005267513
          Length = 6921

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>XP_005267512
          Length = 6922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>XP_005267511
          Length = 6922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIRITKNVP 9
            RIR  +NVP
Sbjct: 3534 RIRSIQNVP 3542
>XP_005273742
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ITKNVP 9
           +TKNVP
Sbjct: 553 LTKNVP 558
>NP_001127854
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           IR+T +VP
Sbjct: 811 IRLTSSVP 818
>NP_055684
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           IR+T +VP
Sbjct: 825 IRLTSSVP 832
>NP_037452
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IRITKNV 8
           +RI+KNV
Sbjct: 684 VRISKNV 690
>NP_060350
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RITKNV 8
           RITKN+
Sbjct: 183 RITKNI 188
>NP_000695
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   ITKNVP 9
           +TKN+P
Sbjct: 791 LTKNIP 796
>NP_065764
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           I +TK+VP
Sbjct: 258 ITVTKSVP 265
>XP_005260283
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRITKNVP 9
           I +TK+VP
Sbjct: 272 ITVTKSVP 279
>XP_005264448
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RITKNV 8
           RITKN+
Sbjct: 183 RITKNI 188
>XP_005264447
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RITKNV 8
           RITKN+
Sbjct: 183 RITKNI 188
>XP_005264446
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RITKNV 8
           RITKN+
Sbjct: 183 RITKNI 188
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.143    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 478,448
Number of extensions: 883
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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