Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              20     299
NP_009297                                                              20     299
NP_001161710                                                           19     665
NP_001161709                                                           19     665
NP_001161708                                                           19     665
NP_009298                                                              19     665
NP_001129473                                                           19     665
NP_005149                                                              19     665
NP_001161711                                                           19     665
XP_005245145                                                           19     665
NP_001129472                                                           19     665
NP_002513                                                              17    2528
NP_055535                                                              17    3301
XP_005270358                                                           17    3301
NP_940980                                                              16    5631
XP_005268686                                                           16    5631
NP_002936                                                              16    7355
NP_065816                                                              16    7355
XP_006710573                                                           16    7355
XP_006710572                                                           16    7355
XP_006710571                                                           16    7355
XP_006710570                                                           16    7355
XP_006710569                                                           16    7355
XP_006710568                                                           16    7355
XP_006710567                                                           16    7355
XP_006710566                                                           16    7355
XP_005245859                                                           16    7355
NP_001073280                                                           15    9605
NP_005210                                                              15    9605
NP_005786                                                              15    9605
NP_001258680                                                           15    9605
NP_001254772                                                           15    9605
NP_004889                                                              15    9605
NP_002218                                                              15    9605
NP_060470                                                              15    9605
NP_115729                                                              15    9605
NP_001122089                                                           15    9605
NP_001273540                                                           15    9605
NP_001030                                                              15    9605
XP_005255526                                                           15    9605
XP_005267235                                                           15    9605
XP_006715650                                                           15    9605
XP_005267234                                                           15    9605
XP_005268441                                                           15    9605
XP_006714117                                                           15    9605
XP_005265844                                                           15    9605
XP_005246291                                                           15    9605
XP_005246289                                                           15    9605
XP_005246288                                                           15    9605
XP_005270898                                                           15    9605
XP_006710687                                                           15    9605
>NP_005148
          Length = 1130

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT SDGK
Sbjct: 175 RINTASDGK 183
>NP_009297
          Length = 1149

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT SDGK
Sbjct: 194 RINTASDGK 202
>NP_001161710
          Length = 1058

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT +DGK
Sbjct: 200 RINTTADGK 208
>NP_001161709
          Length = 1079

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT +DGK
Sbjct: 221 RINTTADGK 229
>NP_001161708
          Length = 1161

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT +DGK
Sbjct: 200 RINTTADGK 208
>NP_009298
          Length = 1182

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT +DGK
Sbjct: 221 RINTTADGK 229
>NP_001129473
          Length = 542

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT +DGK
Sbjct: 200 RINTTADGK 208
>NP_005149
          Length = 1167

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT +DGK
Sbjct: 206 RINTTADGK 214
>NP_001161711
          Length = 1043

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT +DGK
Sbjct: 185 RINTTADGK 193
>XP_005245145
          Length = 1146

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT +DGK
Sbjct: 185 RINTTADGK 193
>NP_001129472
          Length = 1064

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           RINT +DGK
Sbjct: 206 RINTTADGK 214
>NP_002513
          Length = 432

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           R+NT+ +GK
Sbjct: 180 RVNTLEEGK 188
>NP_055535
          Length = 1235

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   INTVSDGK 9
           IN+VS+GK
Sbjct: 444 INSVSEGK 451
>XP_005270358
          Length = 1204

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   INTVSDGK 9
           IN+VS+GK
Sbjct: 444 INSVSEGK 451
>NP_940980
          Length = 2527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RINTVSDGK 9
          R+N V +GK
Sbjct: 22 RLNNVQEGK 30
>XP_005268686
          Length = 2521

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RINTVSDGK 9
          R+N V +GK
Sbjct: 22 RLNNVQEGK 30
>NP_002936
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  INTVSDGK 9
          +NT+ DG+
Sbjct: 84 VNTLKDGR 91
>NP_065816
          Length = 5183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>XP_006710573
          Length = 5177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>XP_006710572
          Length = 5188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>XP_006710571
          Length = 5194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>XP_006710570
          Length = 5195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>XP_006710569
          Length = 5212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>XP_006710568
          Length = 5221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>XP_006710567
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>XP_006710566
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>XP_005245859
          Length = 5223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TVSDGK 9
            T+SDGK
Sbjct: 1771 TISDGK 1776
>NP_001073280
          Length = 1263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   INTVSDGK 9
           +NTV D K
Sbjct: 389 LNTVKDSK 396
>NP_005210
          Length = 1272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   INTVSDGK 9
           +NTV D K
Sbjct: 398 LNTVKDSK 405
>NP_005786
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   INTVSDG 8
           ++T+SDG
Sbjct: 423 VSTISDG 429
>NP_001258680
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   INTVSDG 8
           ++T+SDG
Sbjct: 423 VSTISDG 429
>NP_001254772
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RINTVS 6
           RINTVS
Sbjct: 411 RINTVS 416
>NP_004889
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RINTVS 6
           RINTVS
Sbjct: 411 RINTVS 416
>NP_002218
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    INTVSDGK 9
            +NT+ +GK
Sbjct: 1105 VNTLKEGK 1112
>NP_060470
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RINTVSDGK 9
           +++T+SD K
Sbjct: 129 KLSTISDSK 137
>NP_115729
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   INTVSDGK 9
           I TVSDG+
Sbjct: 164 IITVSDGR 171
>NP_001122089
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTVSDG 8
           NTV+DG
Sbjct: 480 NTVADG 485
>NP_001273540
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTVSDG 8
           NTV+DG
Sbjct: 507 NTVADG 512
>NP_001030
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTVSDGK 9
           N+VS+GK
Sbjct: 144 NSVSEGK 150
>XP_005255526
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NTVSDGK 9
           N+VS+GK
Sbjct: 144 NSVSEGK 150
>XP_005267235
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTVSDG 8
           NTV+DG
Sbjct: 507 NTVADG 512
>XP_006715650
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTVSDG 8
           NTV+DG
Sbjct: 486 NTVADG 491
>XP_005267234
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTVSDG 8
           NTV+DG
Sbjct: 506 NTVADG 511
>XP_005268441
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   INTVSDGK 9
           +NTV D K
Sbjct: 398 LNTVKDSK 405
>XP_006714117
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RINTVS 6
           RINTVS
Sbjct: 411 RINTVS 416
>XP_005265844
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RINTVS 6
           RINTVS
Sbjct: 411 RINTVS 416
>XP_005246291
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   INTVSDG 8
           ++T+SDG
Sbjct: 434 VSTISDG 440
>XP_005246289
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   INTVSDG 8
           ++T+SDG
Sbjct: 434 VSTISDG 440
>XP_005246288
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   INTVSDG 8
           ++T+SDG
Sbjct: 434 VSTISDG 440
>XP_005270898
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    INTVSDGK 9
            +NT+ +GK
Sbjct: 1105 VNTLKEGK 1112
>XP_006710687
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    INTVSDGK 9
            +NT+ +GK
Sbjct: 1105 VNTLKEGK 1112
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.129    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 488,556
Number of extensions: 425
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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