Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           19     665
NP_000170                                                              19     665
NP_001268422                                                           19     665
NP_001268423                                                           19     665
XP_005264328                                                           19     665
NP_001130005                                                           18    1935
NP_001010854                                                           17    2528
XP_005267424                                                           17    2528
XP_006720122                                                           17    2528
XP_006720121                                                           17    2528
NP_653271                                                              17    4312
NP_001269353                                                           17    4312
NP_003726                                                              16    7355
NP_115265                                                              16    7355
NP_001167560                                                           15    9605
NP_114423                                                              15    9605
NP_001167561                                                           15    9605
XP_005260914                                                           15    9605
XP_005260913                                                           15    9605

>NP_001268421
          Length = 1230

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIMSGESIF 9
            RIMSGES F
Sbjct: 1052 RIMSGESTF 1060



>NP_000170
          Length = 1360

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIMSGESIF 9
            RIMSGES F
Sbjct: 1182 RIMSGESTF 1190



>NP_001268422
          Length = 1058

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RIMSGESIF 9
           RIMSGES F
Sbjct: 880 RIMSGESTF 888



>NP_001268423
          Length = 1058

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RIMSGESIF 9
           RIMSGES F
Sbjct: 880 RIMSGESTF 888



>XP_005264328
          Length = 1261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIMSGESIF 9
            RIMSGES F
Sbjct: 1083 RIMSGESTF 1091



>NP_001130005
          Length = 631

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IMSGESIF 9
           +MSGES+F
Sbjct: 94  LMSGESLF 101



>NP_001010854
          Length = 843

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIMSGESIF 9
           R+ SGE+IF
Sbjct: 311 RVYSGENIF 319



>XP_005267424
          Length = 656

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RIMSGESIF 9
          R+ SGE+IF
Sbjct: 53 RVYSGENIF 61



>XP_006720122
          Length = 820

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIMSGESIF 9
           R+ SGE+IF
Sbjct: 217 RVYSGENIF 225



>XP_006720121
          Length = 851

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIMSGESIF 9
           R+ SGE+IF
Sbjct: 319 RVYSGENIF 327



>NP_653271
          Length = 1454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IMSGESIF 9
            I+SGESI+
Sbjct: 1165 IISGESIY 1172



>NP_001269353
          Length = 963

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IMSGESIF 9
           I+SGESI+
Sbjct: 674 IISGESIY 681



>NP_003726
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IMSGESIF 9
           ++SG+S+F
Sbjct: 792 LLSGDSVF 799



>NP_115265
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IMSGESIF 9
           ++SG+S+F
Sbjct: 792 LLSGDSVF 799



>NP_001167560
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IMSGESI 8
          I+SGESI
Sbjct: 59 IVSGESI 65



>NP_114423
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IMSGESI 8
          I+SGESI
Sbjct: 75 IVSGESI 81



>NP_001167561
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IMSGESI 8
           I+SGESI
Sbjct: 102 IVSGESI 108



>XP_005260914
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IMSGESI 8
          I+SGESI
Sbjct: 40 IVSGESI 46



>XP_005260913
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IMSGESI 8
           I+SGESI
Sbjct: 220 IVSGESI 226



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.143    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 517,088
Number of extensions: 431
Number of successful extensions: 19
Number of sequences better than 10000.0: 19
Number of HSP's gapped: 19
Number of HSP's successfully gapped: 19
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)