Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              19     869
NP_001035957                                                           19     869
XP_006721991                                                           19     869
XP_006721990                                                           19     869
XP_006721989                                                           19     869
XP_005258041                                                           19     869
XP_006721988                                                           19     869
XP_006721987                                                           19     869
XP_006721986                                                           19     869
XP_005258040                                                           19     869
XP_006721985                                                           19     869
NP_002903                                                              17    4312
NP_001273361                                                           17    4312
NP_001273360                                                           17    4312
XP_006715607                                                           17    4312
XP_006715606                                                           17    4312
NP_742093                                                              16    7355
NP_001269238                                                           16    7355
NP_001269239                                                           16    7355
NP_473361                                                              16    7355
NP_004411                                                              16    7355
NP_006849                                                              15    9605
NP_001099129                                                           15    9605
NP_060547                                                              15    9605
NP_065962                                                              15    9605
NP_775808                                                              15    9605
XP_006722694                                                           15    9605
XP_005250743                                                           15    9605
XP_006716234                                                           15    9605
XP_005277669                                                           15    9605
XP_005277638                                                           15    9605
XP_005277637                                                           15    9605
XP_005277636                                                           15    9605
XP_006710416                                                           15    9605
XP_006710415                                                           15    9605
XP_005270511                                                           15    9605
XP_005270508                                                           15    9605
NP_001159607                                                           15    9605
NP_001003795                                                           15    9605
>NP_000258
          Length = 2818

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1413 RIERGLKLM 1421
>NP_001035957
          Length = 2839

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1434 RIERGLKLM 1442
>XP_006721991
          Length = 1632

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1444 RIERGLKLM 1452
>XP_006721990
          Length = 2823

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1444 RIERGLKLM 1452
>XP_006721989
          Length = 2823

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1444 RIERGLKLM 1452
>XP_005258041
          Length = 2836

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1413 RIERGLKLM 1421
>XP_006721988
          Length = 2846

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1423 RIERGLKLM 1431
>XP_006721987
          Length = 2849

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1444 RIERGLKLM 1452
>XP_006721986
          Length = 2854

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1431 RIERGLKLM 1439
>XP_005258040
          Length = 2857

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1434 RIERGLKLM 1442
>XP_006721985
          Length = 2867

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIERSLKLM 9
            RIER LKLM
Sbjct: 1444 RIERGLKLM 1452
>NP_002903
          Length = 3130

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IERSLKLM 9
            +ERSLKL+
Sbjct: 2870 LERSLKLL 2877
>NP_001273361
          Length = 3052

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IERSLKLM 9
            +ERSLKL+
Sbjct: 2792 LERSLKLL 2799
>NP_001273360
          Length = 3052

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IERSLKLM 9
            +ERSLKL+
Sbjct: 2792 LERSLKLL 2799
>XP_006715607
          Length = 3052

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IERSLKLM 9
            +ERSLKL+
Sbjct: 2792 LERSLKLL 2799
>XP_006715606
          Length = 3130

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    IERSLKLM 9
            +ERSLKL+
Sbjct: 2870 LERSLKLL 2877
>NP_742093
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIERSLKLM 9
           R+ RSLKL+
Sbjct: 213 RVLRSLKLL 221
>NP_001269238
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIERSLKLM 9
           R+ RSLKL+
Sbjct: 213 RVLRSLKLL 221
>NP_001269239
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIERSLKLM 9
           R+ RSLKL+
Sbjct: 219 RVLRSLKLL 227
>NP_473361
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIERSLKLM 9
           R+ RSLKL+
Sbjct: 213 RVLRSLKLL 221
>NP_004411
          Length = 625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ERSLKLM 9
           ERSLKL+
Sbjct: 297 ERSLKLL 303
>NP_006849
          Length = 227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RIERSLKLM 9
           R+ERS++++
Sbjct: 164 RLERSIQML 172
>NP_001099129
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIERSLK 7
           R+ERS+K
Sbjct: 399 RLERSMK 405
>NP_060547
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIERSLKLM 9
           RI+RSL+ M
Sbjct: 591 RIQRSLQKM 599
>NP_065962
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    RIERSLKL 8
            R+E+ LKL
Sbjct: 1347 RVEKGLKL 1354
>NP_775808
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIERSLK 7
           R+E+SLK
Sbjct: 598 RVEKSLK 604
>XP_006722694
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RIERSLKLM 9
           R+ERS++++
Sbjct: 126 RLERSIQML 134
>XP_005250743
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    RIERSLKL 8
            R+E+ LKL
Sbjct: 1347 RVEKGLKL 1354
>XP_006716234
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    RIERSLKL 8
            R+E+ LKL
Sbjct: 1347 RVEKGLKL 1354
>XP_005277669
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIERSLK 7
           R+E+SLK
Sbjct: 598 RVEKSLK 604
>XP_005277638
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIERSLK 7
           R+E+SLK
Sbjct: 404 RVEKSLK 410
>XP_005277637
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIERSLK 7
           R+E+SLK
Sbjct: 527 RVEKSLK 533
>XP_005277636
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIERSLK 7
           R+E+SLK
Sbjct: 598 RVEKSLK 604
>XP_006710416
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RIERSLK 7
          R+ERS+K
Sbjct: 79 RLERSMK 85
>XP_006710415
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RIERSLK 7
          R+ERS+K
Sbjct: 79 RLERSMK 85
>XP_005270511
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RIERSLK 7
          R+ERS+K
Sbjct: 79 RLERSMK 85
>XP_005270508
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIERSLK 7
           R+ERS+K
Sbjct: 399 RLERSMK 405
>NP_001159607
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RIERSLKLM 9
           RI+RSL+ M
Sbjct: 450 RIQRSLQKM 458
>NP_001003795
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RIERSLK 7
           R+E+SLK
Sbjct: 598 RVEKSLK 604
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.143    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 355,985
Number of extensions: 553
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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