Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              18    1935
XP_005248577                                                           18    1935
XP_005248576                                                           18    1935
NP_000248                                                              17    2528
XP_005267754                                                           17    2528
XP_005267753                                                           17    2528
NP_060064                                                              17    3301
NP_001123520                                                           16    5631
NP_056111                                                              16    5631
NP_001274675                                                           16    5631
NP_001035865                                                           16    5631
NP_061909                                                              16    5631
NP_001274670                                                           16    5631
XP_005254093                                                           16    5631
XP_006720003                                                           16    5631
XP_006720002                                                           16    5631
XP_006720000                                                           16    5631
XP_006719999                                                           16    5631
XP_006719998                                                           16    5631
XP_006719997                                                           16    5631
XP_006719995                                                           16    5631
XP_006719994                                                           16    5631
XP_006719993                                                           16    5631
XP_006719991                                                           16    5631
XP_006719990                                                           16    5631
XP_006719988                                                           16    5631
XP_006719987                                                           16    5631
XP_006719985                                                           16    5631
NP_000704                                                              16    7355
NP_003326                                                              16    7355
XP_005265487                                                           16    7355
XP_006713384                                                           16    7355
NP_060816                                                              16    7355
NP_570629                                                              15    9605
NP_001034439                                                           15    9605
NP_001927                                                              15    9605
NP_001277181                                                           15    9605
XP_005252741                                                           15    9605
XP_006715935                                                           15    9605
XP_006715934                                                           15    9605
NP_005584                                                              15    9605
NP_001012526                                                           15    9605
>NP_005912
          Length = 1512

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIAVFGAAA 9
            RIA FGAAA
Sbjct: 1385 RIADFGAAA 1393
>XP_005248577
          Length = 1349

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIAVFGAAA 9
            RIA FGAAA
Sbjct: 1222 RIADFGAAA 1230
>XP_005248576
          Length = 1375

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RIAVFGAAA 9
            RIA FGAAA
Sbjct: 1248 RIADFGAAA 1256
>NP_000248
          Length = 1935

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  IAVFGAAA 9
          +AVFGAAA
Sbjct: 6  MAVFGAAA 13
>XP_005267754
          Length = 1087

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  IAVFGAAA 9
          +AVFGAAA
Sbjct: 6  MAVFGAAA 13
>XP_005267753
          Length = 1935

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  IAVFGAAA 9
          +AVFGAAA
Sbjct: 6  MAVFGAAA 13
>NP_060064
          Length = 199

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RIAVFGA 7
          R+AVFGA
Sbjct: 9  RVAVFGA 15
>NP_001123520
          Length = 2068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1783 RVAFFGQAA 1791
>NP_056111
          Length = 2069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1784 RVAFFGQAA 1792
>NP_001274675
          Length = 241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  IAVFGAAA 9
          I+VFGAA+
Sbjct: 40 ISVFGAAS 47
>NP_001035865
          Length = 340

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IAVFGAAA 9
           I+VFGAA+
Sbjct: 139 ISVFGAAS 146
>NP_061909
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IAVFGAAA 9
           I+VFGAA+
Sbjct: 169 ISVFGAAS 176
>NP_001274670
          Length = 308

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IAVFGAAA 9
           I+VFGAA+
Sbjct: 107 ISVFGAAS 114
>XP_005254093
          Length = 2046

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1761 RVAFFGQAA 1769
>XP_006720003
          Length = 2058

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1735 RVAFFGQAA 1743
>XP_006720002
          Length = 2058

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1735 RVAFFGQAA 1743
>XP_006720000
          Length = 2084

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1761 RVAFFGQAA 1769
>XP_006719999
          Length = 2095

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1772 RVAFFGQAA 1780
>XP_006719998
          Length = 2103

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1818 RVAFFGQAA 1826
>XP_006719997
          Length = 2104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1818 RVAFFGQAA 1826
>XP_006719995
          Length = 2106

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1783 RVAFFGQAA 1791
>XP_006719994
          Length = 2107

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1784 RVAFFGQAA 1792
>XP_006719993
          Length = 2110

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1787 RVAFFGQAA 1795
>XP_006719991
          Length = 2118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1795 RVAFFGQAA 1803
>XP_006719990
          Length = 2118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1795 RVAFFGQAA 1803
>XP_006719988
          Length = 2129

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1806 RVAFFGQAA 1814
>XP_006719987
          Length = 2130

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1807 RVAFFGQAA 1815
>XP_006719985
          Length = 2141

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RIAVFGAAA 9
            R+A FG AA
Sbjct: 1818 RVAFFGQAA 1826
>NP_000704
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RIAVFGA 7
          +IA+FGA
Sbjct: 5  KIAIFGA 11
>NP_003326
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RIAVFGA 7
           +IAVFGA
Sbjct: 418 QIAVFGA 424
>XP_005265487
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RIAVFGA 7
           +IAVFGA
Sbjct: 418 QIAVFGA 424
>XP_006713384
          Length = 1005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RIAVFGA 7
           +IAVFGA
Sbjct: 418 QIAVFGA 424
>NP_060816
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RIAVFGAA 8
           R+A FGAA
Sbjct: 141 RLAEFGAA 148
>NP_570629
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RIAVFG 6
           R+AVFG
Sbjct: 705 RVAVFG 710
>NP_001034439
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RIAVFG 6
           R+AVFG
Sbjct: 641 RVAVFG 646
>NP_001927
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RIAVFG 6
           R+AVFG
Sbjct: 643 RVAVFG 648
>NP_001277181
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RIAVFG 6
           R+AVFG
Sbjct: 598 RVAVFG 603
>XP_005252741
          Length = 151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RIAVFGAAA 9
          R+A  GAAA
Sbjct: 65 RVAAAGAAA 73
>XP_006715935
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RIAVFG 6
           R+AVFG
Sbjct: 644 RVAVFG 649
>XP_006715934
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RIAVFG 6
           R+AVFG
Sbjct: 644 RVAVFG 649
>NP_005584
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  RIAVFGA 7
          R+A FGA
Sbjct: 35 RVAAFGA 41
>NP_001012526
          Length = 151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RIAVFGAAA 9
          R+A  GAAA
Sbjct: 65 RVAAAGAAA 73
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.140    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 329,367
Number of extensions: 405
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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