Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           18    1482
NP_001185763                                                           18    1482
NP_055459                                                              18    1482
XP_006726410                                                           18    1482
XP_006711719                                                           18    1482
XP_006711718                                                           18    1482
XP_006711717                                                           18    1482
XP_006711716                                                           18    1482
XP_006711715                                                           18    1482
XP_006711714                                                           18    1482
XP_006711713                                                           18    1482
XP_006711712                                                           18    1482
XP_006711711                                                           18    1482
XP_006711710                                                           18    1482
XP_006711709                                                           18    1482
XP_005277503                                                           18    1482
XP_005273038                                                           18    1482
XP_006711708                                                           18    1482
XP_005277500                                                           18    1482
XP_006711707                                                           18    1482
XP_005277499                                                           18    1482
XP_006711706                                                           18    1482
XP_006711705                                                           18    1482
XP_006711164                                                           18    1482
XP_006710140                                                           18    1482
NP_001107228                                                           17    3301
NP_001244918                                                           17    3301
NP_001107227                                                           17    3301
NP_001944                                                              17    3301
NP_001244917                                                           17    3301
NP_001171559                                                           16    5631
NP_003889                                                              16    5631
NP_001097                                                              16    5631
XP_005267257                                                           16    5631
XP_005267256                                                           16    5631
XP_005267255                                                           16    5631
XP_006715655                                                           16    5631
XP_005267254                                                           16    5631
XP_006715654                                                           16    5631
XP_005265640                                                           16    5631
NP_000229                                                              16    7355
NP_001191727                                                           16    7355
NP_742053                                                              16    7355
NP_742054                                                              16    7355
NP_000927                                                              16    7355
NP_110406                                                              16    7355
NP_001265848                                                           16    7355
NP_001265849                                                           16    7355
NP_775115                                                              16    7355
XP_006716040                                                           16    7355
NP_444505                                                              15    9605
NP_000993                                                              15    9605
NP_001092314                                                           15    9605
>NP_001185761
          Length = 2240

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1685 RGTIELGRI 1693
>NP_001185763
          Length = 2362

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1791 RGTIELGRI 1799
>NP_055459
          Length = 2346

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1791 RGTIELGRI 1799
>XP_006726410
          Length = 2087

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1532 RGTIELGRI 1540
>XP_006711719
          Length = 2302

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1747 RGTIELGRI 1755
>XP_006711718
          Length = 1436

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RGTIELVRI 9
           RGTIEL RI
Sbjct: 798 RGTIELGRI 806
>XP_006711717
          Length = 2385

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1747 RGTIELGRI 1755
>XP_006711716
          Length = 2411

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1856 RGTIELGRI 1864
>XP_006711715
          Length = 2428

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1790 RGTIELGRI 1798
>XP_006711714
          Length = 2429

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1791 RGTIELGRI 1799
>XP_006711713
          Length = 2432

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1794 RGTIELGRI 1802
>XP_006711712
          Length = 2473

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1954 RGTIELGRI 1962
>XP_006711711
          Length = 2482

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1844 RGTIELGRI 1852
>XP_006711710
          Length = 2494

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1856 RGTIELGRI 1864
>XP_006711709
          Length = 2495

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1857 RGTIELGRI 1865
>XP_005277503
          Length = 2498

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1954 RGTIELGRI 1962
>XP_005273038
          Length = 2509

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1954 RGTIELGRI 1962
>XP_006711708
          Length = 2512

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1954 RGTIELGRI 1962
>XP_005277500
          Length = 2525

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1954 RGTIELGRI 1962
>XP_006711707
          Length = 2553

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1954 RGTIELGRI 1962
>XP_005277499
          Length = 2561

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1954 RGTIELGRI 1962
>XP_006711706
          Length = 2591

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1953 RGTIELGRI 1961
>XP_006711705
          Length = 2592

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1954 RGTIELGRI 1962
>XP_006711164
          Length = 2087

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RGTIELVRI 9
            RGTIEL RI
Sbjct: 1532 RGTIELGRI 1540
>XP_006710140
          Length = 290

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RGTIELVRI 9
          RGTIEL RI
Sbjct: 44 RGTIELGRI 52
>NP_001107228
          Length = 482

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GTIELVR 8
           GT+ELVR
Sbjct: 387 GTVELVR 393
>NP_001244918
          Length = 487

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GTIELVR 8
           GT+ELVR
Sbjct: 392 GTVELVR 398
>NP_001107227
          Length = 482

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GTIELVR 8
           GT+ELVR
Sbjct: 387 GTVELVR 393
>NP_001944
          Length = 482

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GTIELVR 8
           GT+ELVR
Sbjct: 387 GTVELVR 393
>NP_001244917
          Length = 482

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GTIELVR 8
           GT+ELVR
Sbjct: 387 GTVELVR 393
>NP_001171559
          Length = 1259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GTIELVRI 9
           GTI LVRI
Sbjct: 686 GTIVLVRI 693
>NP_003889
          Length = 1496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GTIELVRI 9
           GTI LVRI
Sbjct: 923 GTIVLVRI 930
>NP_001097
          Length = 512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GTIELVR 8
          GTIELV+
Sbjct: 68 GTIELVK 74
>XP_005267257
          Length = 909

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GTIELVRI 9
           GTI LVRI
Sbjct: 336 GTIVLVRI 343
>XP_005267256
          Length = 1113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GTIELVRI 9
           GTI LVRI
Sbjct: 540 GTIVLVRI 547
>XP_005267255
          Length = 1165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GTIELVRI 9
           GTI LVRI
Sbjct: 592 GTIVLVRI 599
>XP_006715655
          Length = 1288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GTIELVRI 9
           GTI LVRI
Sbjct: 923 GTIVLVRI 930
>XP_005267254
          Length = 1443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GTIELVRI 9
           GTI LVRI
Sbjct: 870 GTIVLVRI 877
>XP_006715654
          Length = 1495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GTIELVRI 9
           GTI LVRI
Sbjct: 922 GTIVLVRI 929
>XP_005265640
          Length = 533

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GTIELVR 8
          GTIELV+
Sbjct: 89 GTIELVK 95
>NP_000229
          Length = 1159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RGTIELVR 8
           RG+IE++R
Sbjct: 784 RGSIEILR 791
>NP_001191727
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RGTIELVR 8
           RG+IE++R
Sbjct: 444 RGSIEILR 451
>NP_742053
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RGTIELVR 8
           RG+IE++R
Sbjct: 784 RGSIEILR 791
>NP_742054
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RGTIELVR 8
           RG+IE++R
Sbjct: 444 RGSIEILR 451
>NP_000927
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGTIELVRI 9
           +GT ELVR+
Sbjct: 200 QGTPELVRL 208
>NP_110406
          Length = 994

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RGTIELVR 8
           RG+IE++R
Sbjct: 636 RGSIEILR 643
>NP_001265848
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RGTIELVR 8
           RG+IE++R
Sbjct: 636 RGSIEILR 643
>NP_001265849
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RGTIELVR 8
           RG+IE++R
Sbjct: 513 RGSIEILR 520
>NP_775115
          Length = 905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RGTIELVR 8
           RG+IE++R
Sbjct: 583 RGSIEILR 590
>XP_006716040
          Length = 1137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RGTIELVR 8
           RG+IE++R
Sbjct: 762 RGSIEILR 769
>NP_444505
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RGTIELV 7
           RGTIE++
Sbjct: 149 RGTIEIL 155
>NP_000993
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RGTIELV 7
           RGTIE++
Sbjct: 149 RGTIEIL 155
>NP_001092314
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TIELVRI 9
           TIE+VR+
Sbjct: 248 TIEMVRV 254
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.155    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 350,448
Number of extensions: 470
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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