Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              20     509
NP_001243397                                                           20     509
XP_005269721                                                           20     509
NP_056453                                                              17    3301
NP_955400                                                              17    3301
NP_001229416                                                           17    3301
NP_001229417                                                           17    3301
NP_055852                                                              17    3301
XP_005269712                                                           17    3301
XP_006717788                                                           17    3301
XP_005269710                                                           17    3301
XP_005269709                                                           17    3301
XP_005269708                                                           17    3301
XP_005269706                                                           17    3301
XP_005269705                                                           17    3301
NP_001268451                                                           16    5631
NP_001268449                                                           16    5631
NP_877954                                                              16    5631
NP_001268450                                                           16    5631
NP_115874                                                              16    5631
XP_005260916                                                           16    5631
NP_958441                                                              16    7355
NP_958439                                                              16    7355
NP_005219                                                              16    7355
NP_001184033                                                           16    7355
NP_005924                                                              16    7355
NP_001699                                                              16    7355
NP_001035514                                                           16    7355
NP_001269863                                                           16    7355
NP_071398                                                              16    7355
XP_006724103                                                           16    7355
XP_006724102                                                           16    7355
XP_006718903                                                           16    7355
XP_006718902                                                           16    7355
NP_001138384                                                           15    9605
NP_001129503                                                           15    9605
NP_006386                                                              15    9605
NP_940867                                                              15    9605
NP_055928                                                              15    9605
NP_004456                                                              15    9605
NP_002354                                                              15    9605
NP_803134                                                              15    9605
NP_775970                                                              15    9605
NP_002358                                                              15    9605
NP_056073                                                              15    9605
NP_004704                                                              15    9605
NP_002355                                                              15    9605
NP_796379                                                              15    9605
NP_872312                                                              15    9605
XP_006724697                                                           15    9605
XP_006724696                                                           15    9605
XP_006724695                                                           15    9605
XP_006724694                                                           15    9605
XP_006721548                                                           15    9605
XP_005256618                                                           15    9605
XP_005256617                                                           15    9605
XP_005268258                                                           15    9605
XP_005268257                                                           15    9605
XP_005268256                                                           15    9605
XP_006717082                                                           15    9605
XP_006717081                                                           15    9605
XP_005248321                                                           15    9605
XP_006712999                                                           15    9605
XP_005264860                                                           15    9605
XP_006712998                                                           15    9605
XP_006712997                                                           15    9605
XP_006712996                                                           15    9605
XP_006712995                                                           15    9605
XP_006712994                                                           15    9605
NP_001138526                                                           15    9605
>NP_036462
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           RGQKTKV T
Sbjct: 374 RGQKTKVCT 382
>NP_001243397
          Length = 1890

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           RGQKTKV T
Sbjct: 374 RGQKTKVCT 382
>XP_005269721
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           RGQKTKV T
Sbjct: 374 RGQKTKVCT 382
>NP_056453
          Length = 797

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           RGQK K+S
Sbjct: 152 RGQKLKIS 159
>NP_955400
          Length = 789

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           RGQK K+S
Sbjct: 152 RGQKLKIS 159
>NP_001229416
          Length = 1837

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 815 KGKKNKVST 823
>NP_001229417
          Length = 1892

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 815 KGKKNKVST 823
>NP_055852
          Length = 1842

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 815 KGKKNKVST 823
>XP_005269712
          Length = 1800

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 781 KGKKNKVST 789
>XP_006717788
          Length = 1829

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 815 KGKKNKVST 823
>XP_005269710
          Length = 1834

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 815 KGKKNKVST 823
>XP_005269709
          Length = 1871

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 781 KGKKNKVST 789
>XP_005269708
          Length = 1897

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 815 KGKKNKVST 823
>XP_005269706
          Length = 1900

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 815 KGKKNKVST 823
>XP_005269705
          Length = 1905

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           +G+K KVST
Sbjct: 815 KGKKNKVST 823
>NP_001268451
          Length = 793

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           +GQKTK S
Sbjct: 366 KGQKTKSS 373
>NP_001268449
          Length = 840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           +GQKTK S
Sbjct: 366 KGQKTKSS 373
>NP_877954
          Length = 824

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           +GQKTK S
Sbjct: 350 KGQKTKSS 357
>NP_001268450
          Length = 880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           +GQKTK S
Sbjct: 366 KGQKTKSS 373
>NP_115874
          Length = 840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           +GQKTK S
Sbjct: 366 KGQKTKSS 373
>XP_005260916
          Length = 581

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           +GQKTK S
Sbjct: 366 KGQKTKSS 373
>NP_958441
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GQKTKV 7
           GQKTK+
Sbjct: 485 GQKTKI 490
>NP_958439
          Length = 628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GQKTKV 7
           GQKTK+
Sbjct: 485 GQKTKI 490
>NP_005219
          Length = 1210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GQKTKV 7
           GQKTK+
Sbjct: 485 GQKTKI 490
>NP_001184033
          Length = 3972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RGQKTKV 7
            +G+KTKV
Sbjct: 2307 KGEKTKV 2313
>NP_005924
          Length = 3969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RGQKTKV 7
            +G+KTKV
Sbjct: 2304 KGEKTKV 2310
>NP_001699
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QKTKVST 9
           QKT+VST
Sbjct: 333 QKTEVST 339
>NP_001035514
          Length = 1178

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           RG+K KVS
Sbjct: 305 RGRKPKVS 312
>NP_001269863
          Length = 1198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           RG+K KVS
Sbjct: 305 RGRKPKVS 312
>NP_071398
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           RG+K KVS
Sbjct: 634 RGRKPKVS 641
>XP_006724103
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           RG+K KVS
Sbjct: 305 RGRKPKVS 312
>XP_006724102
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGQKTKVS 8
           RG+K KVS
Sbjct: 305 RGRKPKVS 312
>XP_006718903
          Length = 2673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RGQKTKV 7
            +G+KTKV
Sbjct: 1008 KGEKTKV 1014
>XP_006718902
          Length = 2964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RGQKTKV 7
            +G+KTKV
Sbjct: 1299 KGEKTKV 1305
>NP_001138384
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 182 QGQRTKIT 189
>NP_001129503
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 221 QGQRTKIT 228
>NP_006386
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 221 QGQRTKIT 228
>NP_940867
          Length = 1582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           R +K+KVST
Sbjct: 682 REKKSKVST 690
>NP_055928
          Length = 2961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RGQKTKVST 9
            RG+KT+  T
Sbjct: 1144 RGRKTRYDT 1152
>NP_004456
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RGQKTK 6
           RGQKT+
Sbjct: 188 RGQKTR 193
>NP_002354
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 RGQKTKV 7
         RGQK+K+
Sbjct: 3 RGQKSKL 9
>NP_803134
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 RGQKTKV 7
         RGQK+K+
Sbjct: 3 RGQKSKL 9
>NP_775970
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 RGQKTKV 7
         RGQK+K+
Sbjct: 3 RGQKSKL 9
>NP_002358
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 RGQKTKV 7
         RGQK+K+
Sbjct: 3 RGQKSKL 9
>NP_056073
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RGQKTKV 7
           RGQ TKV
Sbjct: 684 RGQLTKV 690
>NP_004704
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RGQKTKV 7
           RGQK+K+
Sbjct: 870 RGQKSKM 876
>NP_002355
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 RGQKTKV 7
         RGQK+K+
Sbjct: 3 RGQKSKL 9
>NP_796379
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 RGQKTKV 7
         RGQK+K+
Sbjct: 3 RGQKSKL 9
>NP_872312
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 RGQKTKV 7
         RGQK+K+
Sbjct: 3 RGQKSKL 9
>XP_006724697
          Length = 1526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           R +K+KVST
Sbjct: 682 REKKSKVST 690
>XP_006724696
          Length = 1534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           R +K+KVST
Sbjct: 682 REKKSKVST 690
>XP_006724695
          Length = 1574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           R +K+KVST
Sbjct: 682 REKKSKVST 690
>XP_006724694
          Length = 1582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RGQKTKVST 9
           R +K+KVST
Sbjct: 682 REKKSKVST 690
>XP_006721548
          Length = 1886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RGQKTKVST 9
          RG+KT+  T
Sbjct: 65 RGRKTRYDT 73
>XP_005256618
          Length = 2962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RGQKTKVST 9
            RG+KT+  T
Sbjct: 1145 RGRKTRYDT 1153
>XP_005256617
          Length = 2966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RGQKTKVST 9
            RG+KT+  T
Sbjct: 1145 RGRKTRYDT 1153
>XP_005268258
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RGQKTKV 7
           RGQK+K+
Sbjct: 641 RGQKSKM 647
>XP_005268257
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RGQKTKV 7
           RGQK+K+
Sbjct: 656 RGQKSKM 662
>XP_005268256
          Length = 1055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RGQKTKV 7
           RGQK+K+
Sbjct: 849 RGQKSKM 855
>XP_006717082
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RGQKTKV 7
           RGQ TKV
Sbjct: 616 RGQLTKV 622
>XP_006717081
          Length = 1209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RGQKTKV 7
           RGQ TKV
Sbjct: 674 RGQLTKV 680
>XP_005248321
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RGQKTK 6
           RGQKT+
Sbjct: 188 RGQKTR 193
>XP_006712999
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 221 QGQRTKIT 228
>XP_005264860
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 221 QGQRTKIT 228
>XP_006712998
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 221 QGQRTKIT 228
>XP_006712997
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 221 QGQRTKIT 228
>XP_006712996
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 221 QGQRTKIT 228
>XP_006712995
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 221 QGQRTKIT 228
>XP_006712994
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RGQKTKVS 8
           +GQ+TK++
Sbjct: 221 QGQRTKIT 228
>NP_001138526
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RGQKTK 6
           RG+KTK
Sbjct: 383 RGEKTK 388
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.112    0.276 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,805
Number of extensions: 401
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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