Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003290                                                              18    1135
NP_060960                                                              17    4312
NP_004332                                                              17    4312
XP_005264615                                                           17    4312
XP_006712164                                                           17    4312
XP_005264614                                                           17    4312
XP_005264613                                                           17    4312
XP_005264612                                                           17    4312
NP_001257933                                                           16    5631
NP_570913                                                              16    7355
NP_001230122                                                           16    7355
NP_057667                                                              16    7355
NP_001269853                                                           16    7355
NP_001269857                                                           16    7355
NP_001128217                                                           16    7355
NP_079269                                                              16    7355
XP_005258567                                                           16    7355
NP_789780                                                              16    7355
NP_055628                                                              15    9605
NP_997273                                                              15    9605
NP_001191047                                                           15    9605
>NP_003290
          Length = 803

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RGMTITLVL 9
           RG TITLVL
Sbjct: 243 RGTTITLVL 251
>NP_060960
          Length = 951

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GMTITLVL 9
           G T+TLVL
Sbjct: 705 GFTVTLVL 712
>NP_004332
          Length = 2225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GMTITLV 8
            GMTIT+V
Sbjct: 2072 GMTITMV 2078
>XP_005264615
          Length = 2162

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GMTITLV 8
            GMTIT+V
Sbjct: 2009 GMTITMV 2015
>XP_006712164
          Length = 2179

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GMTITLV 8
            GMTIT+V
Sbjct: 2026 GMTITMV 2032
>XP_005264614
          Length = 2191

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GMTITLV 8
            GMTIT+V
Sbjct: 2038 GMTITMV 2044
>XP_005264613
          Length = 2208

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GMTITLV 8
            GMTIT+V
Sbjct: 2055 GMTITMV 2061
>XP_005264612
          Length = 2242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GMTITLV 8
            GMTIT+V
Sbjct: 2089 GMTITMV 2095
>NP_001257933
          Length = 186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GMTITLV 8
           GMTITL+
Sbjct: 168 GMTITLL 174
>NP_570913
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGMTITLV 8
           RG+ ITLV
Sbjct: 232 RGLDITLV 239
>NP_001230122
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGMTITLV 8
           RG+ ITLV
Sbjct: 232 RGLDITLV 239
>NP_057667
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RGMTITLV 8
           RG+ ITLV
Sbjct: 232 RGLDITLV 239
>NP_001269853
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RGMTITLVL 9
          +GM++ LVL
Sbjct: 10 KGMSVVLVL 18
>NP_001269857
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RGMTITLVL 9
          +GM++ LVL
Sbjct: 11 KGMSVVLVL 19
>NP_001128217
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RGMTITLVL 9
          +GM++ LVL
Sbjct: 10 KGMSVVLVL 18
>NP_079269
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RGMTITLVL 9
          +GM++ LVL
Sbjct: 10 KGMSVVLVL 18
>XP_005258567
          Length = 1036

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTITLVL 9
           GMT+ L+L
Sbjct: 795 GMTVPLIL 802
>NP_789780
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GMTITLVL 9
           GMT+ L+L
Sbjct: 795 GMTVPLIL 802
>NP_055628
          Length = 1065

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RGMTITL 7
           RGM +TL
Sbjct: 511 RGMNVTL 517
>NP_997273
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   GMTITLV 8
           G+T+TL+
Sbjct: 187 GLTVTLI 193
>NP_001191047
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   GMTITLV 8
           G+T+TL+
Sbjct: 187 GLTVTLI 193
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.149    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 304,673
Number of extensions: 389
Number of successful extensions: 21
Number of sequences better than 10000.0: 21
Number of HSP's gapped: 21
Number of HSP's successfully gapped: 21
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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