Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           19     665
NP_001277143                                                           19     665
NP_001077383                                                           19     665
NP_001320                                                              19     665
NP_073713                                                              19     665
XP_005269629                                                           19     665
XP_005269628                                                           19     665
XP_005269627                                                           19     665
XP_005269626                                                           19     665
XP_006717706                                                           19     665
XP_005269625                                                           19     665
XP_005269624                                                           19     665
XP_006717705                                                           19     665
XP_005269622                                                           19     665
XP_005269621                                                           19     665
XP_006717704                                                           19     665
XP_005269619                                                           19     665
XP_005269618                                                           19     665
NP_955452                                                              18    1935
XP_006713543                                                           18    1935
NP_065970                                                              17    4312
XP_006712718                                                           17    4312
XP_005246766                                                           17    4312
XP_006712717                                                           17    4312
NP_001155003                                                           16    5631
NP_001155002                                                           16    5631
NP_001155001                                                           16    5631
NP_079120                                                              16    5631
NP_001155004                                                           16    5631
XP_006724923                                                           16    5631
XP_006724922                                                           16    5631
XP_006724921                                                           16    5631
XP_006724502                                                           16    5631
XP_006724501                                                           16    5631
XP_006724500                                                           16    5631
XP_005257750                                                           16    5631
XP_005257747                                                           16    5631
XP_006722157                                                           16    5631
NP_006131                                                              16    5631
NP_758448                                                              16    5631
NP_060147                                                              16    7355
NP_059509                                                              16    7355
NP_001319                                                              15    9605
NP_001012632                                                           15    9605
NP_689899                                                              15    9605
NP_001277060                                                           15    9605
NP_001028733                                                           15    9605
XP_006724100                                                           15    9605
XP_005258073                                                           15    9605
XP_005258072                                                           15    9605
XP_006714631                                                           15    9605
XP_006714630                                                           15    9605
XP_005271975                                                           15    9605
XP_005271974                                                           15    9605
XP_005272320                                                           15    9605
XP_005272319                                                           15    9605
XP_005272318                                                           15    9605
>NP_001277144
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>NP_001277143
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>NP_001077383
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>NP_001320
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>NP_073713
          Length = 985

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 759 RSLGVQRVY 767
>XP_005269629
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_005269628
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_005269627
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_005269626
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_006717706
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_005269625
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_005269624
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_006717705
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_005269622
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_005269621
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_006717704
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_005269619
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>XP_005269618
          Length = 445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           R LGVQRVY
Sbjct: 219 RSLGVQRVY 227
>NP_955452
          Length = 2590

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    FLGVQRVY 9
            FLG++R+Y
Sbjct: 2223 FLGMERIY 2230
>XP_006713543
          Length = 2591

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    FLGVQRVY 9
            FLG++R+Y
Sbjct: 2224 FLGMERIY 2231
>NP_065970
          Length = 1657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FLGVQRVY 9
            FLGVQR +
Sbjct: 1522 FLGVQRKF 1529
>XP_006712718
          Length = 969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLGVQRVY 9
           FLGVQR +
Sbjct: 834 FLGVQRKF 841
>XP_005246766
          Length = 1656

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FLGVQRVY 9
            FLGVQR +
Sbjct: 1521 FLGVQRKF 1528
>XP_006712717
          Length = 1657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FLGVQRVY 9
            FLGVQR +
Sbjct: 1522 FLGVQRKF 1529
>NP_001155003
          Length = 410

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 348 RFLRIQRLF 356
>NP_001155002
          Length = 434

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 382 RFLRIQRLF 390
>NP_001155001
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 348 RFLRIQRLF 356
>NP_079120
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  FLGVQRV 8
          FLG+QR+
Sbjct: 79 FLGLQRI 85
>NP_001155004
          Length = 267

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 215 RFLRIQRLF 223
>XP_006724923
          Length = 464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 429 RFLRIQRLF 437
>XP_006724922
          Length = 473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 421 RFLRIQRLF 429
>XP_006724921
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 429 RFLRIQRLF 437
>XP_006724502
          Length = 464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 429 RFLRIQRLF 437
>XP_006724501
          Length = 473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 421 RFLRIQRLF 429
>XP_006724500
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 429 RFLRIQRLF 437
>XP_005257750
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  FLGVQRV 8
          FLG+QR+
Sbjct: 79 FLGLQRI 85
>XP_005257747
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  FLGVQRV 8
          FLG+QR+
Sbjct: 79 FLGLQRI 85
>XP_006722157
          Length = 611

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  FLGVQRV 8
          FLG+QR+
Sbjct: 79 FLGLQRI 85
>NP_006131
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 348 RFLRIQRLF 356
>NP_758448
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RFL +QR++
Sbjct: 348 RFLRIQRLF 356
>NP_060147
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           RF+G++ ++
Sbjct: 269 RFMGIENIH 277
>NP_059509
          Length = 655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FLGVQRVY 9
           FLG+ R+Y
Sbjct: 336 FLGIIRLY 343
>NP_001319
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RFLGVQRV 8
           R LG+QRV
Sbjct: 213 RALGLQRV 220
>NP_001012632
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RFLGVQRV 8
           R LG+QRV
Sbjct: 202 RALGLQRV 209
>NP_689899
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RFLGVQRV 8
          + LGVQR+
Sbjct: 70 QLLGVQRI 77
>NP_001277060
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           +FL +QR++
Sbjct: 751 KFLALQRIH 759
>NP_001028733
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           +FL +QR++
Sbjct: 751 KFLALQRIH 759
>XP_006724100
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LGVQRVY 9
           LGV+++Y
Sbjct: 299 LGVEKIY 305
>XP_005258073
          Length = 787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           +FL +QR++
Sbjct: 534 KFLALQRIH 542
>XP_005258072
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RFLGVQRVY 9
           +FL +QR++
Sbjct: 661 KFLALQRIH 669
>XP_006714631
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RFLGVQRV 8
          + LGVQR+
Sbjct: 70 QLLGVQRI 77
>XP_006714630
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RFLGVQRV 8
          + LGVQR+
Sbjct: 70 QLLGVQRI 77
>XP_005271975
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RFLGVQRV 8
          + LGVQR+
Sbjct: 70 QLLGVQRI 77
>XP_005271974
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RFLGVQRV 8
          + LGVQR+
Sbjct: 70 QLLGVQRI 77
>XP_005272320
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RFLGVQRV 8
           R LG+QRV
Sbjct: 202 RALGLQRV 209
>XP_005272319
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RFLGVQRV 8
           R LG+QRV
Sbjct: 202 RALGLQRV 209
>XP_005272318
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RFLGVQRV 8
           R LG+QRV
Sbjct: 213 RALGLQRV 220
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.346    0.160    0.490 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 446,759
Number of extensions: 657
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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