Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     390
NP_001091680                                                           20     390
NP_001091679                                                           20     390
XP_006713048                                                           20     390
XP_006713047                                                           20     390
XP_006713046                                                           20     390
XP_005264943                                                           20     390
NP_116164                                                              17    2528
XP_006724406                                                           17    2528
XP_006724405                                                           17    2528
NP_036424                                                              17    3301
NP_001245257                                                           17    3301
XP_006722776                                                           17    3301
NP_710142                                                              17    4312
NP_001269973                                                           17    4312
NP_055805                                                              17    4312
NP_001269972                                                           17    4312
NP_919277                                                              17    4312
XP_005267555                                                           17    4312
XP_006720166                                                           17    4312
XP_005267550                                                           17    4312
XP_005267549                                                           17    4312
XP_005267548                                                           17    4312
XP_006720165                                                           17    4312
XP_006720164                                                           17    4312
XP_006720163                                                           17    4312
XP_006720162                                                           17    4312
XP_006720161                                                           17    4312
XP_006714837                                                           17    4312
NP_001815                                                              16    7355
NP_001091954                                                           16    7355
NP_003750                                                              16    7355
NP_001128214                                                           16    7355
NP_061862                                                              16    7355
XP_005258554                                                           16    7355
XP_005268525                                                           16    7355
XP_005268524                                                           16    7355
XP_006714850                                                           16    7355
XP_005268523                                                           16    7355
XP_006714462                                                           16    7355
XP_006714461                                                           16    7355
XP_005265761                                                           16    7355
NP_004658                                                              15    9605
NP_602296                                                              15    9605
NP_065076                                                              15    9605
NP_001611                                                              15    9605
NP_001138523                                                           15    9605
NP_689473                                                              15    9605
XP_006723662                                                           15    9605
XP_005260825                                                           15    9605
XP_006723661                                                           15    9605
XP_006720790                                                           15    9605
XP_005268334                                                           15    9605
XP_005268333                                                           15    9605
XP_006720789                                                           15    9605
XP_005253784                                                           15    9605
XP_005253782                                                           15    9605
XP_006719060                                                           15    9605
XP_006719059                                                           15    9605
XP_006719058                                                           15    9605
XP_005253778                                                           15    9605
XP_005253777                                                           15    9605
XP_006718751                                                           15    9605
XP_006718750                                                           15    9605
XP_005274303                                                           15    9605
XP_006718749                                                           15    9605
XP_005274302                                                           15    9605
XP_005274301                                                           15    9605
XP_005274300                                                           15    9605
XP_005274299                                                           15    9605
XP_005274298                                                           15    9605
XP_005274297                                                           15    9605
XP_006710312                                                           15    9605
>NP_001895
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           R AGGLQKM
Sbjct: 274 RLAGGLQKM 282
>NP_001091680
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           R AGGLQKM
Sbjct: 274 RLAGGLQKM 282
>NP_001091679
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           R AGGLQKM
Sbjct: 274 RLAGGLQKM 282
>XP_006713048
          Length = 720

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           R AGGLQKM
Sbjct: 274 RLAGGLQKM 282
>XP_006713047
          Length = 774

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           R AGGLQKM
Sbjct: 267 RLAGGLQKM 275
>XP_006713046
          Length = 774

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           R AGGLQKM
Sbjct: 267 RLAGGLQKM 275
>XP_005264943
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           R AGGLQKM
Sbjct: 274 RLAGGLQKM 282
>NP_116164
          Length = 634

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  FAGGLQKM 9
          FAGGL++M
Sbjct: 79 FAGGLKEM 86
>XP_006724406
          Length = 666

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   FAGGLQKM 9
           FAGGL++M
Sbjct: 111 FAGGLKEM 118
>XP_006724405
          Length = 682

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   FAGGLQKM 9
           FAGGL++M
Sbjct: 127 FAGGLKEM 134
>NP_036424
          Length = 1136

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           RFA GL+K+
Sbjct: 125 RFAEGLEKL 133
>NP_001245257
          Length = 1152

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           RFA GL+K+
Sbjct: 141 RFAEGLEKL 149
>XP_006722776
          Length = 1164

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RFAGGLQKM 9
           RFA GL+K+
Sbjct: 125 RFAEGLEKL 133
>NP_710142
          Length = 899

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RFAGGL 6
           RFAGGL
Sbjct: 531 RFAGGL 536
>NP_001269973
          Length = 2083

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 1901 FMGGLQK 1907
>NP_055805
          Length = 2036

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 1854 FMGGLQK 1860
>NP_001269972
          Length = 2049

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 1867 FMGGLQK 1873
>NP_919277
          Length = 2083

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 1854 FMGGLQK 1860
>XP_005267555
          Length = 1325

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 1095 FMGGLQK 1101
>XP_006720166
          Length = 2083

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 1901 FMGGLQK 1907
>XP_005267550
          Length = 2084

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 1854 FMGGLQK 1860
>XP_005267549
          Length = 2130

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 1901 FMGGLQK 1907
>XP_005267548
          Length = 2131

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 1901 FMGGLQK 1907
>XP_006720165
          Length = 2542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 2360 FMGGLQK 2366
>XP_006720164
          Length = 2542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 2360 FMGGLQK 2366
>XP_006720163
          Length = 2543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 2313 FMGGLQK 2319
>XP_006720162
          Length = 2589

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 2360 FMGGLQK 2366
>XP_006720161
          Length = 2590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQK
Sbjct: 2360 FMGGLQK 2366
>XP_006714837
          Length = 628

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RFAGGLQK 8
           R+AGGL K
Sbjct: 568 RYAGGLGK 575
>NP_001815
          Length = 381

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RFAGGLQKM 9
           RF  GLQK+
Sbjct: 252 RFCVGLQKI 260
>NP_001091954
          Length = 1079

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RFAGGLQK 8
           RF GGL K
Sbjct: 441 RFCGGLIK 448
>NP_003750
          Length = 1035

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RFAGGLQK 8
           RF GGL K
Sbjct: 397 RFCGGLIK 404
>NP_001128214
          Length = 1094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RFAGGLQK 8
           RF GGL K
Sbjct: 441 RFCGGLIK 448
>NP_061862
          Length = 1060

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGLQKM 9
           GG+QKM
Sbjct: 726 GGIQKM 731
>XP_005258554
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RFAGGLQKM 9
           RF  GLQK+
Sbjct: 326 RFCVGLQKI 334
>XP_005268525
          Length = 1005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGLQKM 9
           GG+QKM
Sbjct: 671 GGIQKM 676
>XP_005268524
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGLQKM 9
           GG+QKM
Sbjct: 672 GGIQKM 677
>XP_006714850
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGLQKM 9
           GG+QKM
Sbjct: 715 GGIQKM 720
>XP_005268523
          Length = 1061

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGLQKM 9
           GG+QKM
Sbjct: 727 GGIQKM 732
>XP_006714462
          Length = 1084

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RFAGGLQK 8
           RF GGL K
Sbjct: 446 RFCGGLIK 453
>XP_006714461
          Length = 1099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RFAGGLQK 8
           RF GGL K
Sbjct: 461 RFCGGLIK 468
>XP_005265761
          Length = 1110

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RFAGGLQK 8
           RF GGL K
Sbjct: 472 RFCGGLIK 479
>NP_004658
          Length = 4834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    FAGGLQ 7
            F+GGLQ
Sbjct: 1342 FSGGLQ 1347
>NP_602296
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RFAGGLQKM 9
          R AGG QK+
Sbjct: 55 RMAGGGQKV 63
>NP_065076
          Length = 1873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQ+
Sbjct: 1693 FMGGLQR 1699
>NP_001611
          Length = 5890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 5612 KFAGGL 5617
>NP_001138523
          Length = 219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FAGGLQ 7
           F+GGLQ
Sbjct: 160 FSGGLQ 165
>NP_689473
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FAGGLQKM 9
           F GGL+K+
Sbjct: 135 FEGGLRKV 142
>XP_006723662
          Length = 1920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQ+
Sbjct: 1740 FMGGLQR 1746
>XP_005260825
          Length = 1923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQ+
Sbjct: 1693 FMGGLQR 1699
>XP_006723661
          Length = 1970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    FAGGLQK 8
            F GGLQ+
Sbjct: 1740 FMGGLQR 1746
>XP_006720790
          Length = 4748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    FAGGLQ 7
            F+GGLQ
Sbjct: 1256 FSGGLQ 1261
>XP_005268334
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    FAGGLQ 7
            F+GGLQ
Sbjct: 1304 FSGGLQ 1309
>XP_005268333
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    FAGGLQ 7
            F+GGLQ
Sbjct: 1304 FSGGLQ 1309
>XP_006720789
          Length = 4829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    FAGGLQ 7
            F+GGLQ
Sbjct: 1337 FSGGLQ 1342
>XP_005253784
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RFAGGLQKM 9
          R AGG QK+
Sbjct: 55 RMAGGGQKV 63
>XP_005253782
          Length = 301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RFAGGLQKM 9
          R AGG QK+
Sbjct: 55 RMAGGGQKV 63
>XP_006719060
          Length = 301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RFAGGLQKM 9
          R AGG QK+
Sbjct: 55 RMAGGGQKV 63
>XP_006719059
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RFAGGLQKM 9
          R AGG QK+
Sbjct: 55 RMAGGGQKV 63
>XP_006719058
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RFAGGLQKM 9
          R AGG QK+
Sbjct: 55 RMAGGGQKV 63
>XP_005253778
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RFAGGLQKM 9
          R AGG QK+
Sbjct: 55 RMAGGGQKV 63
>XP_005253777
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RFAGGLQKM 9
          R AGG QK+
Sbjct: 55 RMAGGGQKV 63
>XP_006718751
          Length = 3489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 3211 KFAGGL 3216
>XP_006718750
          Length = 4001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 3723 KFAGGL 3728
>XP_005274303
          Length = 4506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 4228 KFAGGL 4233
>XP_006718749
          Length = 4596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 4318 KFAGGL 4323
>XP_005274302
          Length = 5438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 5160 KFAGGL 5165
>XP_005274301
          Length = 5762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 5484 KFAGGL 5489
>XP_005274300
          Length = 5762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 5484 KFAGGL 5489
>XP_005274299
          Length = 5762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 5484 KFAGGL 5489
>XP_005274298
          Length = 5890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 5612 KFAGGL 5617
>XP_005274297
          Length = 5890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RFAGGL 6
            +FAGGL
Sbjct: 5612 KFAGGL 5617
>XP_006710312
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  FAGGLQ 7
          F+GGLQ
Sbjct: 10 FSGGLQ 15
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.146    0.431 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 627,087
Number of extensions: 836
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package