Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     665
XP_005266703                                                           19     665
NP_001166101                                                           17    3301
XP_006723066                                                           17    3301
XP_006723065                                                           17    3301
XP_005258546                                                           17    3301
XP_006723064                                                           17    3301
XP_005258545                                                           17    3301
XP_005258544                                                           17    3301
XP_006723063                                                           17    3301
XP_006723062                                                           17    3301
NP_001140155                                                           17    4312
XP_006720296                                                           17    4312
NP_001165599                                                           16    5631
NP_004317                                                              16    5631
NP_757366                                                              16    5631
NP_085152                                                              16    5631
XP_005254400                                                           16    5631
XP_005254399                                                           16    5631
XP_005277475                                                           16    5631
XP_005277474                                                           16    5631
XP_006711546                                                           16    5631
XP_005273028                                                           16    5631
XP_005244774                                                           16    5631
XP_005244773                                                           16    5631
XP_005244772                                                           16    5631
XP_005244771                                                           16    5631
XP_006710392                                                           16    5631
NP_079023                                                              16    7355
NP_861515                                                              16    7355
NP_001268671                                                           16    7355
NP_008950                                                              16    7355
NP_001268670                                                           16    7355
NP_861516                                                              16    7355
XP_006718995                                                           16    7355
XP_005274425                                                           16    7355
XP_006718994                                                           16    7355
XP_006718993                                                           16    7355
XP_005274424                                                           16    7355
XP_005274423                                                           16    7355
NP_203753                                                              16    7355
NP_689991                                                              15    9605
NP_065805                                                              15    9605
NP_002408                                                              15    9605
NP_001139438                                                           15    9605
NP_001245344                                                           15    9605
NP_065860                                                              15    9605
NP_001245347                                                           15    9605
NP_001245346                                                           15    9605
NP_001245345                                                           15    9605
NP_219363                                                              15    9605
NP_001166150                                                           15    9605
XP_005271685                                                           15    9605
XP_006718956                                                           15    9605
XP_006717927                                                           15    9605
XP_005262957                                                           15    9605
XP_005262955                                                           15    9605
XP_005262954                                                           15    9605
XP_005262953                                                           15    9605
XP_005262950                                                           15    9605
XP_005247728                                                           15    9605
XP_006713777                                                           15    9605
NP_061744                                                              15    9605
NP_114478                                                              15    9605
NP_115271                                                              15    9605
NP_116175                                                              15    9605
NP_061749                                                              15    9605
>NP_443179
          Length = 2170

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   REPLAVSVA 9
           REP+AVSVA
Sbjct: 769 REPVAVSVA 777
>XP_005266703
          Length = 1501

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   REPLAVSVA 9
           REP+AVSVA
Sbjct: 100 REPVAVSVA 108
>NP_001166101
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EPLAVSV 8
           EPLAVSV
Sbjct: 661 EPLAVSV 667
>XP_006723066
          Length = 818

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EPLAVSV 8
           EPLAVSV
Sbjct: 328 EPLAVSV 334
>XP_006723065
          Length = 1162

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EPLAVSV 8
           EPLAVSV
Sbjct: 672 EPLAVSV 678
>XP_005258546
          Length = 1259

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EPLAVSV 8
           EPLAVSV
Sbjct: 797 EPLAVSV 803
>XP_006723064
          Length = 1270

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EPLAVSV 8
           EPLAVSV
Sbjct: 808 EPLAVSV 814
>XP_005258545
          Length = 1287

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EPLAVSV 8
           EPLAVSV
Sbjct: 797 EPLAVSV 803
>XP_005258544
          Length = 1288

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EPLAVSV 8
           EPLAVSV
Sbjct: 798 EPLAVSV 804
>XP_006723063
          Length = 1297

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EPLAVSV 8
           EPLAVSV
Sbjct: 807 EPLAVSV 813
>XP_006723062
          Length = 1298

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EPLAVSV 8
           EPLAVSV
Sbjct: 808 EPLAVSV 814
>NP_001140155
          Length = 217

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  PLAVSVA 9
          PLAVSVA
Sbjct: 48 PLAVSVA 54
>XP_006720296
          Length = 217

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  PLAVSVA 9
          PLAVSVA
Sbjct: 48 PLAVSVA 54
>NP_001165599
          Length = 1331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   REPLAVSVA 9
           REP+ +S+A
Sbjct: 550 REPVVLSIA 558
>NP_004317
          Length = 1426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   REPLAVSVA 9
           R+PL +SVA
Sbjct: 843 RKPLDISVA 851
>NP_757366
          Length = 1332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   REPLAVSVA 9
           REP+ +S+A
Sbjct: 550 REPVVLSIA 558
>NP_085152
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   REPLAVSV 8
           R+PLA++V
Sbjct: 770 RDPLAIAV 777
>XP_005254400
          Length = 1378

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   REPLAVSVA 9
           REP+ +S+A
Sbjct: 597 REPVVLSIA 605
>XP_005254399
          Length = 1379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   REPLAVSVA 9
           REP+ +S+A
Sbjct: 597 REPVVLSIA 605
>XP_005277475
          Length = 1352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   REPLAVSVA 9
           R+PL +SVA
Sbjct: 769 RKPLDISVA 777
>XP_005277474
          Length = 1414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   REPLAVSVA 9
           R+PL +SVA
Sbjct: 843 RKPLDISVA 851
>XP_006711546
          Length = 1426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   REPLAVSVA 9
           R+PL +SVA
Sbjct: 843 RKPLDISVA 851
>XP_005273028
          Length = 1426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   REPLAVSVA 9
           R+PL +SVA
Sbjct: 843 RKPLDISVA 851
>XP_005244774
          Length = 493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   REPLAVSV 8
           R+PLA++V
Sbjct: 429 RDPLAIAV 436
>XP_005244773
          Length = 792

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   REPLAVSV 8
           R+PLA++V
Sbjct: 728 RDPLAIAV 735
>XP_005244772
          Length = 801

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   REPLAVSV 8
           R+PLA++V
Sbjct: 737 RDPLAIAV 744
>XP_005244771
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   REPLAVSV 8
           R+PLA++V
Sbjct: 738 RDPLAIAV 745
>XP_006710392
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   REPLAVSV 8
           R+PLA++V
Sbjct: 770 RDPLAIAV 777
>NP_079023
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   REPLAV 6
           REPLAV
Sbjct: 265 REPLAV 270
>NP_861515
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  REPLAVSVA 9
          R+P A SVA
Sbjct: 6  RDPAATSVA 14
>NP_001268671
          Length = 79

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  REPLAVSVA 9
          R+P A SVA
Sbjct: 6  RDPAATSVA 14
>NP_008950
          Length = 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  REPLAVSVA 9
          R+P A SVA
Sbjct: 6  RDPAATSVA 14
>NP_001268670
          Length = 132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  REPLAVSVA 9
          R+P A SVA
Sbjct: 6  RDPAATSVA 14
>NP_861516
          Length = 150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  REPLAVSVA 9
          R+P A SVA
Sbjct: 6  RDPAATSVA 14
>XP_006718995
          Length = 2382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    REPLAVSVA 9
            R+PL VS++
Sbjct: 1654 RDPLRVSIS 1662
>XP_005274425
          Length = 2566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    REPLAVSVA 9
            R+PL VS++
Sbjct: 1839 RDPLRVSIS 1847
>XP_006718994
          Length = 2567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    REPLAVSVA 9
            R+PL VS++
Sbjct: 1839 RDPLRVSIS 1847
>XP_006718993
          Length = 2602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    REPLAVSVA 9
            R+PL VS++
Sbjct: 1874 RDPLRVSIS 1882
>XP_005274424
          Length = 2614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    REPLAVSVA 9
            R+PL VS++
Sbjct: 1887 RDPLRVSIS 1895
>XP_005274423
          Length = 2615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    REPLAVSVA 9
            R+PL VS++
Sbjct: 1887 RDPLRVSIS 1895
>NP_203753
          Length = 2601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    REPLAVSVA 9
            R+PL VS++
Sbjct: 1874 RDPLRVSIS 1882
>NP_689991
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   REPLAVSV 8
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>NP_065805
          Length = 1444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EPLAVSV 8
           EP AVSV
Sbjct: 488 EPFAVSV 494
>NP_002408
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    EPLAVS 7
            EPLAVS
Sbjct: 2494 EPLAVS 2499
>NP_001139438
          Length = 2896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    EPLAVS 7
            EPLAVS
Sbjct: 2134 EPLAVS 2139
>NP_001245344
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EPLAVSVA 9
           +P+A+SVA
Sbjct: 774 KPVAISVA 781
>NP_065860
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EPLAVSVA 9
           +P+A+SVA
Sbjct: 797 KPVAISVA 804
>NP_001245347
          Length = 1155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EPLAVSVA 9
           +P+A+SVA
Sbjct: 761 KPVAISVA 768
>NP_001245346
          Length = 1155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EPLAVSVA 9
           +P+A+SVA
Sbjct: 761 KPVAISVA 768
>NP_001245345
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EPLAVSVA 9
           +P+A+SVA
Sbjct: 771 KPVAISVA 778
>NP_219363
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  REPLAVSVA 9
          REP AVS A
Sbjct: 21 REPGAVSFA 29
>NP_001166150
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  REPLAVSVA 9
          REP AVS A
Sbjct: 21 REPGAVSFA 29
>XP_005271685
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EPLAVSVA 9
           +P+A+SVA
Sbjct: 340 KPVAISVA 347
>XP_006718956
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EPLAVSVA 9
           +P+A+SVA
Sbjct: 797 KPVAISVA 804
>XP_006717927
          Length = 2406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    EPLAVS 7
            EPLAVS
Sbjct: 1644 EPLAVS 1649
>XP_005262957
          Length = 229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   REPLAVSV 8
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005262955
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   REPLAVSV 8
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005262954
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   REPLAVSV 8
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005262953
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   REPLAVSV 8
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005262950
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   REPLAVSV 8
           +EPL VS+
Sbjct: 104 KEPLIVSI 111
>XP_005247728
          Length = 1413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EPLAVSV 8
           EP AVSV
Sbjct: 457 EPFAVSV 463
>XP_006713777
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EPLAVSV 8
           EP AVSV
Sbjct: 468 EPFAVSV 474
>NP_061744
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EPLAVSV 8
           EPL VSV
Sbjct: 789 EPLCVSV 795
>NP_114478
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EPLAVSV 8
           EPL VSV
Sbjct: 789 EPLCVSV 795
>NP_115271
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EPLAVS 7
           EPLAVS
Sbjct: 497 EPLAVS 502
>NP_116175
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PLAVSVA 9
           P+AVSVA
Sbjct: 386 PVAVSVA 392
>NP_061749
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EPLAVS 7
           EPLAVS
Sbjct: 497 EPLAVS 502
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.125    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 575,306
Number of extensions: 786
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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