Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              20     390
NP_001750                                                              17    2528
NP_065711                                                              17    2528
XP_005253870                                                           17    2528
XP_006723058                                                           17    3301
NP_001073903                                                           17    3301
NP_000844                                                              17    4312
NP_060101                                                              17    4312
XP_005261646                                                           17    4312
XP_005261645                                                           17    4312
XP_005261644                                                           17    4312
XP_005245393                                                           17    4312
NP_940907                                                              16    5631
NP_001139566                                                           16    7355
NP_055782                                                              16    7355
NP_001139568                                                           16    7355
NP_001139567                                                           16    7355
NP_055111                                                              16    7355
NP_001171019                                                           16    7355
NP_001171020                                                           16    7355
NP_001236                                                              16    7355
NP_942143                                                              16    7355
NP_001171018                                                           16    7355
NP_942142                                                              16    7355
XP_006725604                                                           16    7355
XP_006725603                                                           16    7355
XP_006725602                                                           16    7355
XP_006725601                                                           16    7355
XP_006725600                                                           16    7355
XP_005254293                                                           16    7355
XP_005254289                                                           16    7355
XP_005254292                                                           16    7355
XP_005254291                                                           16    7355
XP_005254290                                                           16    7355
XP_005265065                                                           16    7355
XP_006713143                                                           16    7355
NP_055632                                                              16    7355
NP_001245210                                                           15    9605
NP_000242                                                              15    9605
NP_003608                                                              15    9605
NP_001241678                                                           15    9605
NP_115784                                                              15    9605
NP_001280                                                              15    9605
NP_001166203                                                           15    9605
NP_068557                                                              15    9605
NP_001001483                                                           15    9605
NP_001166210                                                           15    9605
NP_054865                                                              15    9605
NP_115852                                                              15    9605
NP_115853                                                              15    9605
NP_001166214                                                           15    9605
NP_997281                                                              15    9605
NP_061901                                                              15    9605
XP_006724523                                                           15    9605
XP_006724522                                                           15    9605
XP_005253053                                                           15    9605
XP_005250740                                                           15    9605
XP_005250619                                                           15    9605
XP_005264389                                                           15    9605
>NP_004295
          Length = 1620

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           EDKILQNT
Sbjct: 641 EDKILQNT 648
>NP_001750
          Length = 289

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  REDKILQN 8
          R+D++LQN
Sbjct: 22 RDDRVLQN 29
>NP_065711
          Length = 321

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   REDKILQN 8
           REDK LQN
Sbjct: 140 REDKKLQN 147
>XP_005253870
          Length = 217

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  REDKILQN 8
          R+D++LQN
Sbjct: 22 RDDRVLQN 29
>XP_006723058
          Length = 1460

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   REDKILQN 8
           RE+K+L+N
Sbjct: 954 REEKVLEN 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   REDKILQN 8
           RE+K L+N
Sbjct: 969 REEKALEN 976
>NP_001073903
          Length = 1489

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   REDKILQN 8
           RE+K+L+N
Sbjct: 983 REEKVLEN 990

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    REDKILQN 8
            RE+K L+N
Sbjct: 998  REEKALEN 1005
>NP_000844
          Length = 240

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EDKILQN 8
           EDK LQN
Sbjct: 148 EDKFLQN 154
>NP_060101
          Length = 1712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   REDKILQN 8
           +EDKI++N
Sbjct: 940 QEDKIIEN 947
>XP_005261646
          Length = 122

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  EDKILQN 8
          EDK LQN
Sbjct: 30 EDKFLQN 36
>XP_005261645
          Length = 122

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  EDKILQN 8
          EDK LQN
Sbjct: 30 EDKFLQN 36
>XP_005261644
          Length = 289

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EDKILQN 8
           EDK LQN
Sbjct: 197 EDKFLQN 203
>XP_005245393
          Length = 2663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    REDKILQN 8
            RE+KIL+N
Sbjct: 2635 RENKILRN 2642
>NP_940907
          Length = 1218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EDKILQN 8
            ED ILQN
Sbjct: 1132 EDSILQN 1138
>NP_001139566
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>NP_055782
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>NP_001139568
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>NP_001139567
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>NP_055111
          Length = 813

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DKILQN 8
           DK+LQN
Sbjct: 129 DKVLQN 134
>NP_001171019
          Length = 389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KILQNT 9
           KILQNT
Sbjct: 265 KILQNT 270
>NP_001171020
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KILQNT 9
           KILQNT
Sbjct: 243 KILQNT 248
>NP_001236
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KILQNT 9
           KILQNT
Sbjct: 254 KILQNT 259
>NP_942143
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KILQNT 9
           KILQNT
Sbjct: 254 KILQNT 259
>NP_001171018
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KILQNT 9
           KILQNT
Sbjct: 202 KILQNT 207
>NP_942142
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KILQNT 9
           KILQNT
Sbjct: 238 KILQNT 243
>XP_006725604
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_006725603
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_006725602
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_006725601
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_006725600
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_005254293
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_005254289
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_005254292
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_005254291
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_005254290
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EDKILQNT 9
           ED+IL+N+
Sbjct: 202 EDQILENS 209
>XP_005265065
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DKILQN 8
           DK+LQN
Sbjct: 129 DKVLQN 134
>XP_006713143
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  DKILQN 8
          DK+LQN
Sbjct: 85 DKVLQN 90
>NP_055632
          Length = 811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   REDKILQ 7
           RED++LQ
Sbjct: 801 REDRLLQ 807
>NP_001245210
          Length = 868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   REDKILQN 8
           +E+K+L+N
Sbjct: 462 KEEKVLRN 469
>NP_000242
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   REDKILQN 8
           +E+K+L+N
Sbjct: 528 KEEKVLRN 535
>NP_003608
          Length = 181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  DKILQN 8
          DK+LQN
Sbjct: 66 DKLLQN 71
>NP_001241678
          Length = 185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  DKILQN 8
          DK+LQN
Sbjct: 66 DKLLQN 71
>NP_115784
          Length = 1483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EDKILQN 8
           EDKI+ N
Sbjct: 229 EDKIISN 235
>NP_001280
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EDKILQNT 9
           EDK ++NT
Sbjct: 231 EDKEIENT 238
>NP_001166203
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   REDKILQ 7
           RED +LQ
Sbjct: 420 REDSVLQ 426
>NP_068557
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   REDKILQ 7
           RED +LQ
Sbjct: 470 REDSVLQ 476
>NP_001001483
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  DKILQNT 9
          DKI QNT
Sbjct: 83 DKIHQNT 89
>NP_001166210
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   REDKILQ 7
           RED +LQ
Sbjct: 470 REDSVLQ 476
>NP_054865
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  REDKILQ 7
          R+DK+LQ
Sbjct: 76 RKDKLLQ 82
>NP_115852
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  REDKILQ 7
          R+DK+LQ
Sbjct: 76 RKDKLLQ 82
>NP_115853
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  REDKILQ 7
          R+DK+LQ
Sbjct: 76 RKDKLLQ 82
>NP_001166214
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   REDKILQ 7
           RED +LQ
Sbjct: 470 REDSVLQ 476
>NP_997281
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   REDKILQN 8
           +ED +LQN
Sbjct: 391 KEDFVLQN 398
>NP_061901
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKILQNT 9
           DKI QNT
Sbjct: 213 DKIHQNT 219
>XP_006724523
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   REDKILQ 7
           RED +LQ
Sbjct: 470 REDSVLQ 476
>XP_006724522
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   REDKILQ 7
           RED +LQ
Sbjct: 470 REDSVLQ 476
>XP_005253053
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  DKILQNT 9
          DKI QNT
Sbjct: 83 DKIHQNT 89
>XP_005250740
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EDKILQN 8
           EDKI+ N
Sbjct: 229 EDKIISN 235
>XP_005250619
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  REDKILQ 7
          R+DK+LQ
Sbjct: 76 RKDKLLQ 82
>XP_005264389
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   REDKILQN 8
           +E+K+L+N
Sbjct: 528 KEEKVLRN 535
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.128    0.323 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 638,909
Number of extensions: 1451
Number of successful extensions: 61
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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