Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              18    1135
XP_006713721                                                           18    1135
XP_006724601                                                           17    3301
NP_056069                                                              17    4312
NP_055633                                                              17    4312
XP_006718461                                                           17    4312
XP_006718460                                                           17    4312
XP_006716380                                                           17    4312
XP_006716379                                                           17    4312
XP_005273516                                                           17    4312
XP_005273515                                                           17    4312
NP_001013754                                                           16    5631
NP_997254                                                              16    5631
XP_005252508                                                           16    5631
XP_006717511                                                           16    5631
XP_005252507                                                           16    5631
NP_036370                                                              16    7355
NP_001135970                                                           16    7355
NP_001026                                                              16    7355
NP_066270                                                              16    7355
NP_001191957                                                           16    7355
NP_059136                                                              16    7355
NP_001015001                                                           16    7355
NP_001230141                                                           16    7355
NP_065880                                                              16    7355
NP_001193486                                                           16    7355
NP_001193856                                                           16    7355
XP_006723389                                                           16    7355
XP_005254555                                                           16    7355
XP_005254207                                                           16    7355
XP_005269084                                                           16    7355
XP_005269083                                                           16    7355
XP_005269720                                                           16    7355
XP_006717800                                                           16    7355
XP_005251580                                                           16    7355
XP_006715067                                                           16    7355
XP_006711873                                                           16    7355
XP_006711871                                                           16    7355
XP_006711870                                                           16    7355
XP_006711869                                                           16    7355
XP_006711868                                                           16    7355
XP_006711867                                                           16    7355
XP_006711866                                                           16    7355
XP_006711865                                                           16    7355
NP_006653                                                              15    9605
NP_001116856                                                           15    9605
NP_001116855                                                           15    9605
NP_060215                                                              15    9605
NP_001116857                                                           15    9605
NP_115495                                                              15    9605
NP_112503                                                              15    9605
NP_000094                                                              15    9605
NP_060222                                                              15    9605
NP_001018126                                                           15    9605
NP_116162                                                              15    9605
XP_006724733                                                           15    9605
XP_006724732                                                           15    9605
XP_005272677                                                           15    9605
XP_005272676                                                           15    9605
XP_005272675                                                           15    9605
XP_005272674                                                           15    9605
XP_006724599                                                           15    9605
XP_005272673                                                           15    9605
XP_006720469                                                           15    9605
XP_005254248                                                           15    9605
XP_005254247                                                           15    9605
XP_006713856                                                           15    9605
XP_005269424                                                           15    9605
XP_006713855                                                           15    9605
XP_005269422                                                           15    9605
XP_006713854                                                           15    9605
XP_005269420                                                           15    9605
XP_005269419                                                           15    9605
>NP_006209
          Length = 1068

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RDRLSEITE 9
           RD LSEITE
Sbjct: 537 RDPLSEITE 545
>XP_006713721
          Length = 1068

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RDRLSEITE 9
           RD LSEITE
Sbjct: 537 RDPLSEITE 545
>XP_006724601
          Length = 1020

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DRLSEITE 9
           DRLSEI E
Sbjct: 786 DRLSEIPE 793
>NP_056069
          Length = 1826

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDRLSEIT 8
           RDR SE+T
Sbjct: 979 RDRWSEVT 986
>NP_055633
          Length = 1216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RDRLSEITE 9
           +DRLSE T+
Sbjct: 912 QDRLSEATQ 920
>XP_006718461
          Length = 1247

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RDRLSEITE 9
           +DRLSE T+
Sbjct: 943 QDRLSEATQ 951
>XP_006718460
          Length = 1392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RDRLSEITE 9
            +DRLSE T+
Sbjct: 1088 QDRLSEATQ 1096
>XP_006716380
          Length = 1762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDRLSEIT 8
           RDR SE+T
Sbjct: 915 RDRWSEVT 922
>XP_006716379
          Length = 1762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDRLSEIT 8
           RDR SE+T
Sbjct: 915 RDRWSEVT 922
>XP_005273516
          Length = 1762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDRLSEIT 8
           RDR SE+T
Sbjct: 915 RDRWSEVT 922
>XP_005273515
          Length = 1805

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDRLSEIT 8
           RDR SE+T
Sbjct: 979 RDRWSEVT 986
>NP_001013754
          Length = 846

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           RD+  EITE
Sbjct: 616 RDKQKEITE 624
>NP_997254
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DRLSEIT 8
           DR+SEIT
Sbjct: 548 DRVSEIT 554
>XP_005252508
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DRLSEIT 8
           DR+SEIT
Sbjct: 548 DRVSEIT 554
>XP_006717511
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DRLSEIT 8
           DR+SEIT
Sbjct: 548 DRVSEIT 554
>XP_005252507
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DRLSEIT 8
           DR+SEIT
Sbjct: 548 DRVSEIT 554
>NP_036370
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLSEITE 9
           +LSEITE
Sbjct: 506 KLSEITE 512
>NP_001135970
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLSEITE 9
           +LSEITE
Sbjct: 211 KLSEITE 217
>NP_001026
          Length = 4967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RDRLSEI 7
            RDR+SE+
Sbjct: 4663 RDRISEL 4669
>NP_066270
          Length = 417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLSEITE 9
           RLSE+TE
Sbjct: 208 RLSEMTE 214
>NP_001191957
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DRLSEIT 8
           DRLSEI+
Sbjct: 645 DRLSEIS 651
>NP_059136
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DRLSEIT 8
           DRLSEI+
Sbjct: 680 DRLSEIS 686
>NP_001015001
          Length = 417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLSEITE 9
           RLSE+TE
Sbjct: 208 RLSEMTE 214
>NP_001230141
          Length = 266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           RD L ++TE
Sbjct: 248 RDELKKVTE 256
>NP_065880
          Length = 1423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RLSEITE 9
            +LSEITE
Sbjct: 1344 KLSEITE 1350
>NP_001193486
          Length = 1386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RLSEITE 9
            +LSEITE
Sbjct: 1307 KLSEITE 1313
>NP_001193856
          Length = 4707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    DRLSEIT 8
            DR+SE+T
Sbjct: 1580 DRISELT 1586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RDRLSEITE 9
            RD + EIT+
Sbjct: 3123 RDEMDEITQ 3131
>XP_006723389
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           RD L ++TE
Sbjct: 289 RDELKKVTE 297
>XP_005254555
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RLSEITE 9
          RLSE+TE
Sbjct: 49 RLSEMTE 55
>XP_005254207
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RLSEITE 9
          RLSE+TE
Sbjct: 49 RLSEMTE 55
>XP_005269084
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DRLSEIT 8
           DRLSEI+
Sbjct: 588 DRLSEIS 594
>XP_005269083
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DRLSEIT 8
           DRLSEI+
Sbjct: 690 DRLSEIS 696
>XP_005269720
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLSEITE 9
           +LSEITE
Sbjct: 203 KLSEITE 209
>XP_006717800
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLSEITE 9
           +LSEITE
Sbjct: 455 KLSEITE 461
>XP_005251580
          Length = 1422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RLSEITE 9
            +LSEITE
Sbjct: 1343 KLSEITE 1349
>XP_006715067
          Length = 4707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    DRLSEIT 8
            DR+SE+T
Sbjct: 1580 DRISELT 1586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RDRLSEITE 9
            RD + EIT+
Sbjct: 3123 RDEMDEITQ 3131
>XP_006711873
          Length = 4954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RDRLSEI 7
            RDR+SE+
Sbjct: 4650 RDRISEL 4656
>XP_006711871
          Length = 4906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RDRLSEI 7
            RDR+SE+
Sbjct: 4602 RDRISEL 4608
>XP_006711870
          Length = 4965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RDRLSEI 7
            RDR+SE+
Sbjct: 4661 RDRISEL 4667
>XP_006711869
          Length = 4973

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RDRLSEI 7
            RDR+SE+
Sbjct: 4669 RDRISEL 4675
>XP_006711868
          Length = 4975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RDRLSEI 7
            RDR+SE+
Sbjct: 4671 RDRISEL 4677
>XP_006711867
          Length = 4977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RDRLSEI 7
            RDR+SE+
Sbjct: 4673 RDRISEL 4679
>XP_006711866
          Length = 4984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RDRLSEI 7
            RDR+SE+
Sbjct: 4680 RDRISEL 4686
>XP_006711865
          Length = 4985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RDRLSEI 7
            RDR+SE+
Sbjct: 4681 RDRISEL 4687
>NP_006653
          Length = 3230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DRLSEITE 9
            D+LSEI E
Sbjct: 1967 DQLSEIIE 1974
>NP_001116856
          Length = 1703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>NP_001116855
          Length = 1721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>NP_060215
          Length = 1721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>NP_001116857
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>NP_115495
          Length = 6306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DRLSEITE 9
            D+LSEI E
Sbjct: 5081 DQLSEIEE 5088
>NP_112503
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DRLSEIT 8
           DRL E+T
Sbjct: 173 DRLEEVT 179
>NP_000094
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DRLSEIT 8
           DRL E+T
Sbjct: 173 DRLEEVT 179
>NP_060222
          Length = 1120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           RD L ++TE
Sbjct: 626 RDHLPQLTE 634
>NP_001018126
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RDRLSEITE 9
          ++RLS +TE
Sbjct: 15 QNRLSSVTE 23
>NP_116162
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RDRLSEI 7
          R+RLSEI
Sbjct: 91 RNRLSEI 97
>XP_006724733
          Length = 1022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           RD L ++TE
Sbjct: 528 RDHLPQLTE 536
>XP_006724732
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           RD L ++TE
Sbjct: 576 RDHLPQLTE 584
>XP_005272677
          Length = 1703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>XP_005272676
          Length = 1737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>XP_005272675
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>XP_005272674
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>XP_006724599
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>XP_005272673
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDRLSEITE 9
           R+R SEI E
Sbjct: 761 RNRFSEILE 769
>XP_006720469
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DRLSEIT 8
          DRL E+T
Sbjct: 71 DRLEEVT 77
>XP_005254248
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DRLSEIT 8
           DRL E+T
Sbjct: 173 DRLEEVT 179
>XP_005254247
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DRLSEIT 8
           DRL E+T
Sbjct: 173 DRLEEVT 179
>XP_006713856
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RDRLSEI 7
          R+RLSEI
Sbjct: 91 RNRLSEI 97
>XP_005269424
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RDRLSEI 7
          R+RLSEI
Sbjct: 91 RNRLSEI 97
>XP_006713855
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RDRLSEI 7
          R+RLSEI
Sbjct: 91 RNRLSEI 97
>XP_005269422
          Length = 767

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RDRLSEI 7
          R+RLSEI
Sbjct: 91 RNRLSEI 97
>XP_006713854
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RDRLSEI 7
          R+RLSEI
Sbjct: 91 RNRLSEI 97
>XP_005269420
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RDRLSEI 7
          R+RLSEI
Sbjct: 91 RNRLSEI 97
>XP_005269419
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RDRLSEI 7
          R+RLSEI
Sbjct: 91 RNRLSEI 97
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.129    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 381,524
Number of extensions: 657
Number of successful extensions: 75
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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