Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004963                                                              20     390
XP_005251512                                                           20     390
NP_037423                                                              18    1935
XP_006716613                                                           18    1935
XP_006716612                                                           18    1935
XP_006716611                                                           18    1935
NP_008930                                                              17    2528
NP_001165276                                                           17    2528
NP_001035374                                                           17    2528
NP_001035375                                                           17    2528
XP_006721308                                                           17    2528
XP_005256150                                                           17    2528
XP_005256149                                                           17    2528
XP_006714501                                                           17    2528
XP_005248291                                                           17    2528
NP_000206                                                              17    4312
XP_006722808                                                           17    4312
XP_005259953                                                           17    4312
NP_001258625                                                           16    5631
NP_001258627                                                           16    5631
NP_004290                                                              16    5631
NP_001258628                                                           16    5631
NP_006109                                                              16    5631
NP_001018238                                                           16    5631
NP_002652                                                              16    5631
NP_001258626                                                           16    5631
NP_006707                                                              16    5631
XP_006715906                                                           16    5631
XP_005250178                                                           16    5631
XP_005250177                                                           16    5631
NP_777360                                                              16    7355
NP_001265237                                                           16    7355
NP_001265235                                                           16    7355
NP_001265236                                                           16    7355
NP_001265234                                                           16    7355
NP_002807                                                              16    7355
NP_542409                                                              16    7355
NP_056250                                                              15    9605
NP_002709                                                              15    9605
NP_001165419                                                           15    9605
NP_076974                                                              15    9605
NP_037512                                                              15    9605
NP_036557                                                              15    9605
NP_001076804                                                           15    9605
NP_001267468                                                           15    9605
NP_904355                                                              15    9605
NP_001165420                                                           15    9605
XP_005260130                                                           15    9605
XP_006722946                                                           15    9605
XP_005252609                                                           15    9605
XP_005250910                                                           15    9605
XP_006713749                                                           15    9605
>NP_004963
          Length = 1132

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RDLNSLFT 8
           RDLNSLFT
Sbjct: 803 RDLNSLFT 810
>XP_005251512
          Length = 1132

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RDLNSLFT 8
           RDLNSLFT
Sbjct: 803 RDLNSLFT 810
>NP_037423
          Length = 1443

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RDLNSLFTT 9
           RDL+ +FTT
Sbjct: 702 RDLSGMFTT 710
>XP_006716613
          Length = 785

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RDLNSLFTT 9
          RDL+ +FTT
Sbjct: 44 RDLSGMFTT 52
>XP_006716612
          Length = 1365

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RDLNSLFTT 9
           RDL+ +FTT
Sbjct: 624 RDLSGMFTT 632
>XP_006716611
          Length = 1440

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RDLNSLFTT 9
           RDL+ +FTT
Sbjct: 702 RDLSGMFTT 710
>NP_008930
          Length = 542

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDLNSLFT 8
           RDLN +FT
Sbjct: 141 RDLNEVFT 148
>NP_001165276
          Length = 541

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDLNSLFT 8
           RDLN +FT
Sbjct: 141 RDLNEVFT 148
>NP_001035374
          Length = 698

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDLNSLFT 8
           RDLN +FT
Sbjct: 350 RDLNEVFT 357
>NP_001035375
          Length = 651

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDLNSLFT 8
           RDLN +FT
Sbjct: 350 RDLNEVFT 357
>XP_006721308
          Length = 666

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDLNSLFT 8
           RDLN +FT
Sbjct: 365 RDLNEVFT 372
>XP_005256150
          Length = 687

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDLNSLFT 8
           RDLN +FT
Sbjct: 365 RDLNEVFT 372
>XP_005256149
          Length = 713

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDLNSLFT 8
           RDLN +FT
Sbjct: 365 RDLNEVFT 372
>XP_006714501
          Length = 425

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDLNSLFT 8
           RDLN +FT
Sbjct: 141 RDLNEVFT 148
>XP_005248291
          Length = 792

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDLNSLFT 8
           RDLN +FT
Sbjct: 391 RDLNEVFT 398
>NP_000206
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RDLNSLFTT 9
           RDLNSL ++
Sbjct: 775 RDLNSLISS 783
>XP_006722808
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RDLNSLFTT 9
           RDLNSL ++
Sbjct: 775 RDLNSLISS 783
>XP_005259953
          Length = 1167

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RDLNSLFTT 9
           RDLNSL ++
Sbjct: 818 RDLNSLISS 826
>NP_001258625
          Length = 752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLNSLFT 8
           D+N+LFT
Sbjct: 440 DMNTLFT 446
>NP_001258627
          Length = 726

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLNSLFT 8
           D+N+LFT
Sbjct: 414 DMNTLFT 420
>NP_004290
          Length = 753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLNSLFT 8
           D+N+LFT
Sbjct: 441 DMNTLFT 447
>NP_001258628
          Length = 713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLNSLFT 8
           D+N+LFT
Sbjct: 401 DMNTLFT 407
>NP_006109
          Length = 279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDLNSLFT 8
          RD NS+F+
Sbjct: 86 RDFNSIFS 93
>NP_001018238
          Length = 231

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDLNSLFT 8
          RD NS+F+
Sbjct: 38 RDFNSIFS 45
>NP_002652
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RDLNSLF 7
           RD+NSL+
Sbjct: 747 RDINSLY 753
>NP_001258626
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DLNSLFT 8
           D+N+LFT
Sbjct: 400 DMNTLFT 406
>NP_006707
          Length = 674

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDLNSLFT 8
           +DL+S+FT
Sbjct: 521 KDLHSIFT 528
>XP_006715906
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDLNSLFT 8
           +DL+S+FT
Sbjct: 297 KDLHSIFT 304
>XP_005250178
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDLNSLFT 8
           +DL+S+FT
Sbjct: 297 KDLHSIFT 304
>XP_005250177
          Length = 673

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDLNSLFT 8
           +DL+S+FT
Sbjct: 520 KDLHSIFT 527
>NP_777360
          Length = 436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDLNSLFTT 9
           +DL  LFTT
Sbjct: 283 KDLLKLFTT 291
>NP_001265237
          Length = 164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LNSLFT 8
           LNSLFT
Sbjct: 143 LNSLFT 148
>NP_001265235
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LNSLFT 8
           LNSLFT
Sbjct: 119 LNSLFT 124
>NP_001265236
          Length = 153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LNSLFT 8
           LNSLFT
Sbjct: 111 LNSLFT 116
>NP_001265234
          Length = 185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LNSLFT 8
           LNSLFT
Sbjct: 143 LNSLFT 148
>NP_002807
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RDLNSLFTT 9
           +DL  LFTT
Sbjct: 303 KDLLKLFTT 311
>NP_542409
          Length = 185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LNSLFT 8
           LNSLFT
Sbjct: 143 LNSLFT 148
>NP_056250
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DLNSLFTT 9
           D NS+F+T
Sbjct: 104 DKNSIFST 111
>NP_002709
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  DLNSLF 7
          DLNS+F
Sbjct: 67 DLNSMF 72
>NP_001165419
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RDLNSLF 7
          RDL+S+F
Sbjct: 75 RDLDSIF 81
>NP_076974
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RDLNSLF 7
          RDL+S+F
Sbjct: 75 RDLDSIF 81
>NP_037512
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DLNSLF 7
           DLNS+F
Sbjct: 367 DLNSIF 372
>NP_036557
          Length = 277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DLNSLFT 8
          D+N LFT
Sbjct: 32 DVNGLFT 38
>NP_001076804
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DLNSLF 7
           DLNS+F
Sbjct: 373 DLNSIF 378
>NP_001267468
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DLNSLFTT 9
           D NS+F+T
Sbjct: 104 DKNSIFST 111
>NP_904355
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DLNSLFTT 9
           D NS+F+T
Sbjct: 104 DKNSIFST 111
>NP_001165420
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RDLNSLF 7
          RDL+S+F
Sbjct: 75 RDLDSIF 81
>XP_005260130
          Length = 104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RDLNSLF 7
          RDL+S+F
Sbjct: 75 RDLDSIF 81
>XP_006722946
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RDLNSLF 7
          RDL+S+F
Sbjct: 75 RDLDSIF 81
>XP_005252609
          Length = 277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DLNSLFT 8
          D+N LFT
Sbjct: 32 DVNGLFT 38
>XP_005250910
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DLNSLFTT 9
           D NS+F+T
Sbjct: 104 DKNSIFST 111
>XP_006713749
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  DLNSLF 7
          DLNS+F
Sbjct: 67 DLNSMF 72
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.134    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,058
Number of extensions: 842
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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