Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              21     229
XP_006717989                                                           21     229
NP_055811                                                              18    1935
XP_005247296                                                           18    1935
XP_006713604                                                           18    1935
XP_005247295                                                           18    1935
NP_001124432                                                           18    1935
NP_001675                                                              17    4312
NP_001001396                                                           17    4312
NP_005372                                                              17    4312
NP_006182                                                              16    5631
NP_003048                                                              16    7355
NP_001157787                                                           16    7355
XP_006726459                                                           16    7355
XP_006726458                                                           16    7355
XP_005276270                                                           16    7355
XP_005276269                                                           16    7355
XP_005276268                                                           16    7355
XP_006726457                                                           16    7355
XP_003960344                                                           16    7355
XP_006712956                                                           16    7355
XP_006712955                                                           16    7355
XP_006712954                                                           16    7355
XP_006712953                                                           16    7355
XP_006712952                                                           16    7355
XP_006712951                                                           16    7355
XP_005263994                                                           16    7355
XP_006712579                                                           16    7355
XP_006712578                                                           16    7355
XP_006712577                                                           16    7355
XP_006710200                                                           16    7355
XP_006710199                                                           16    7355
XP_006710198                                                           16    7355
XP_006710197                                                           16    7355
NP_001276324                                                           15    9605
NP_003313                                                              15    9605
NP_000375                                                              15    9605
NP_056370                                                              15    9605
NP_001026794                                                           15    9605
NP_001001331                                                           15    9605
NP_055105                                                              15    9605
NP_001005783                                                           15    9605
NP_001265577                                                           15    9605
NP_813977                                                              15    9605
NP_003311                                                              15    9605
NP_036386                                                              15    9605
NP_001032903                                                           15    9605
NP_068812                                                              15    9605
NP_065078                                                              15    9605
NP_057611                                                              15    9605
NP_001265576                                                           15    9605
NP_005332                                                              15    9605
XP_006718366                                                           15    9605
XP_005253166                                                           15    9605
XP_005267163                                                           15    9605
XP_005249051                                                           15    9605
XP_006713243                                                           15    9605
XP_006713242                                                           15    9605
XP_006713239                                                           15    9605
XP_005265236                                                           15    9605
XP_006713238                                                           15    9605
XP_005265134                                                           15    9605
XP_005265135                                                           15    9605
XP_005265133                                                           15    9605
XP_005270972                                                           15    9605
XP_005270971                                                           15    9605
XP_005270970                                                           15    9605
XP_006710654                                                           15    9605
NP_848600                                                              15    9605
NP_689699                                                              15    9605
>NP_000305
          Length = 403

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RDKKGVAIP 9
           RDKKGV IP
Sbjct: 161 RDKKGVTIP 169
>XP_006717989
          Length = 388

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RDKKGVAIP 9
           RDKKGV IP
Sbjct: 146 RDKKGVTIP 154
>NP_055811
          Length = 1655

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RDKKGVAI 8
            RDKKGV +
Sbjct: 1486 RDKKGVTV 1493
>XP_005247296
          Length = 1673

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RDKKGVAI 8
            RDKKGV +
Sbjct: 1504 RDKKGVTV 1511
>XP_006713604
          Length = 1685

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RDKKGVAI 8
            RDKKGV +
Sbjct: 1516 RDKKGVTV 1523
>XP_005247295
          Length = 1705

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RDKKGVAI 8
            RDKKGV +
Sbjct: 1536 RDKKGVTV 1543
>NP_001124432
          Length = 1693

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RDKKGVAI 8
            RDKKGV +
Sbjct: 1524 RDKKGVTV 1531
>NP_001675
          Length = 1205

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           D+KG A+P
Sbjct: 606 DRKGEAVP 613
>NP_001001396
          Length = 1170

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           D+KG A+P
Sbjct: 606 DRKGEAVP 613
>NP_005372
          Length = 710

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KKGVAIP 9
           KKG AIP
Sbjct: 124 KKGAAIP 130
>NP_006182
          Length = 394

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  KKGVAIP 9
          KKG+A P
Sbjct: 71 KKGIAFP 77
>NP_003048
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           + KGVA+P
Sbjct: 515 ETKGVALP 522
>NP_001157787
          Length = 1941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 462 DKEGKALP 469
>XP_006726459
          Length = 1140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_006726458
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_005276270
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_005276269
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_005276268
          Length = 1368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_006726457
          Length = 1490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_003960344
          Length = 2085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_006712956
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_006712955
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_006712954
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_006712953
          Length = 1402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_006712952
          Length = 1524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_006712951
          Length = 2119

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 496 DKEGKALP 503
>XP_005263994
          Length = 1496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DKKGVAIP 9
          DK+G A+P
Sbjct: 43 DKEGKALP 50
>XP_006712579
          Length = 1865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 462 DKEGKALP 469
>XP_006712578
          Length = 1914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 462 DKEGKALP 469
>XP_006712577
          Length = 1915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 462 DKEGKALP 469
>XP_006710200
          Length = 1119

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 417 DKEGKALP 424
>XP_006710199
          Length = 1241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 417 DKEGKALP 424
>XP_006710198
          Length = 1314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 417 DKEGKALP 424
>XP_006710197
          Length = 1836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           DK+G A+P
Sbjct: 417 DKEGKALP 424
>NP_001276324
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           RDKKG+
Sbjct: 258 RDKKGM 263
>NP_003313
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           RDKKG+
Sbjct: 311 RDKKGM 316
>NP_000375
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RDKKGVA 7
            +DKKG++
Sbjct: 3992 KDKKGIS 3998
>NP_056370
          Length = 1013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DKKGVAIP 9
           D KG+A P
Sbjct: 286 DNKGIAHP 293
>NP_001026794
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DKKGVAIP 9
           D KG+A P
Sbjct: 286 DNKGIAHP 293
>NP_001001331
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           +DKKGV
Sbjct: 299 KDKKGV 304
>NP_055105
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  KKGVAIP 9
          K GVA+P
Sbjct: 19 KNGVALP 25
>NP_001005783
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KKGVAIP 9
           KKG AIP
Sbjct: 186 KKGNAIP 192
>NP_001265577
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           ++KG A+P
Sbjct: 283 NRKGTAVP 290
>NP_813977
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           RDKKG+
Sbjct: 271 RDKKGM 276
>NP_003311
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           RDKKG+
Sbjct: 326 RDKKGM 331
>NP_036386
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RDKKGVAIP 9
           RD +G  IP
Sbjct: 478 RDNQGFCIP 486
>NP_001032903
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DKKGVAIP 9
           D +GV IP
Sbjct: 378 DSQGVCIP 385
>NP_068812
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           + KG+A+P
Sbjct: 519 ETKGIALP 526
>NP_065078
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDKKGVAI 8
           +DKK VAI
Sbjct: 108 KDKKEVAI 115
>NP_057611
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KKGVAIP 9
           KKG AIP
Sbjct: 186 KKGNAIP 192
>NP_001265576
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           ++KG A+P
Sbjct: 283 NRKGTAVP 290
>NP_005332
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           ++KG A+P
Sbjct: 283 NRKGTAVP 290
>XP_006718366
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           RDKKG+
Sbjct: 313 RDKKGM 318
>XP_005253166
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           RDKKG+
Sbjct: 313 RDKKGM 318
>XP_005267163
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           + KG+A+P
Sbjct: 388 ETKGIALP 395
>XP_005249051
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DKKGVAIP 9
           D KG+A P
Sbjct: 286 DNKGIAHP 293
>XP_006713243
          Length = 1199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_006713242
          Length = 1205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_006713239
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_005265236
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_006713238
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RDKKGV 6
           +DKKGV
Sbjct: 299 KDKKGV 304
>XP_005265134
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDKKGVAI 8
           +DKK VAI
Sbjct: 108 KDKKEVAI 115
>XP_005265135
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDKKGVAI 8
           +DKK VAI
Sbjct: 108 KDKKEVAI 115
>XP_005265133
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RDKKGVAI 8
           +DKK VAI
Sbjct: 108 KDKKEVAI 115
>XP_005270972
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KKGVAIP 9
           KKG AIP
Sbjct: 199 KKGNAIP 205
>XP_005270971
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KKGVAIP 9
           KKG AIP
Sbjct: 174 KKGNAIP 180
>XP_005270970
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KKGVAIP 9
           KKG AIP
Sbjct: 199 KKGNAIP 205
>XP_006710654
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DKKGVAIP 9
           ++KG A+P
Sbjct: 283 NRKGTAVP 290
>NP_848600
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKGVAIP 9
           K+G+AIP
Sbjct: 347 KEGLAIP 353
>NP_689699
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DKKGVAIP 9
          DK+ VA+P
Sbjct: 31 DKRTVALP 38
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.141    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 563,059
Number of extensions: 1238
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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