Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002040                                                              20     390
NP_722575                                                              18    1935
XP_005247180                                                           18    1935
NP_663622                                                              17    2528
XP_005251162                                                           17    2528
XP_005251161                                                           17    2528
XP_005251160                                                           17    2528
XP_005251159                                                           17    2528
NP_001138560                                                           17    2528
NP_003794                                                              17    4312
NP_062830                                                              17    4312
NP_059125                                                              16    5631
NP_001074961                                                           16    5631
NP_060729                                                              16    5631
NP_872313                                                              16    5631
XP_005268733                                                           16    5631
XP_005268732                                                           16    5631
XP_005253074                                                           16    5631
XP_006718326                                                           16    5631
XP_005253073                                                           16    5631
NP_061822                                                              16    5631
NP_004387                                                              16    7355
NP_005245                                                              16    7355
NP_057738                                                              16    7355
XP_006721801                                                           16    7355
XP_005257168                                                           16    7355
XP_006720521                                                           16    7355
XP_006720520                                                           16    7355
XP_005254331                                                           16    7355
XP_005254330                                                           16    7355
XP_006720519                                                           16    7355
XP_006720518                                                           16    7355
XP_005247407                                                           16    7355
NP_001122318                                                           15    9605
NP_001122320                                                           15    9605
NP_001122321                                                           15    9605
NP_001122317                                                           15    9605
NP_003063                                                              15    9605
NP_001122319                                                           15    9605
NP_001122316                                                           15    9605
NP_002787                                                              15    9605
NP_001158109                                                           15    9605
NP_775898                                                              15    9605
NP_004215                                                              15    9605
NP_001158110                                                           15    9605
NP_114141                                                              15    9605
NP_056081                                                              15    9605
NP_001247420                                                           15    9605
XP_006723821                                                           15    9605
XP_006723820                                                           15    9605
XP_006723819                                                           15    9605
XP_005260092                                                           15    9605
XP_005260091                                                           15    9605
XP_005260090                                                           15    9605
XP_005260089                                                           15    9605
XP_005260088                                                           15    9605
XP_005260087                                                           15    9605
XP_005260085                                                           15    9605
XP_006722910                                                           15    9605
XP_006722909                                                           15    9605
XP_006722908                                                           15    9605
XP_006721905                                                           15    9605
XP_005257303                                                           15    9605
XP_006721904                                                           15    9605
XP_006721903                                                           15    9605
XP_006721902                                                           15    9605
XP_006721901                                                           15    9605
XP_005257301                                                           15    9605
XP_006721900                                                           15    9605
XP_006711533                                                           15    9605
XP_005245422                                                           15    9605
NP_065821                                                              15    9605
NP_055190                                                              15    9605
>NP_002040
          Length = 413

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RDAEAYRRS 9
          RDAEAYR S
Sbjct: 64 RDAEAYRHS 72
>NP_722575
          Length = 346

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           DAEAYR++
Sbjct: 249 DAEAYRKT 256
>XP_005247180
          Length = 207

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           DAEAYR++
Sbjct: 110 DAEAYRKT 117
>NP_663622
          Length = 1066

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DAEAYRR 8
           DA+AYRR
Sbjct: 849 DADAYRR 855
>XP_005251162
          Length = 961

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DAEAYRR 8
           DA+AYRR
Sbjct: 744 DADAYRR 750
>XP_005251161
          Length = 987

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DAEAYRR 8
           DA+AYRR
Sbjct: 770 DADAYRR 776
>XP_005251160
          Length = 1001

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DAEAYRR 8
           DA+AYRR
Sbjct: 849 DADAYRR 855
>XP_005251159
          Length = 1035

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DAEAYRR 8
           DA+AYRR
Sbjct: 818 DADAYRR 824
>NP_001138560
          Length = 970

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   DAEAYRR 8
           DA+AYRR
Sbjct: 818 DADAYRR 824
>NP_003794
          Length = 1685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RDAEAYRRS 9
          R++EA+RR+
Sbjct: 56 RESEAFRRA 64
>NP_062830
          Length = 1589

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RDAEAYRRS 9
          R++EA+RR+
Sbjct: 56 RESEAFRRA 64
>NP_059125
          Length = 547

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  RDAEAYRRS 9
          RD E Y RS
Sbjct: 63 RDGEVYYRS 71
>NP_001074961
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DAEAYRRS 9
           +AEAY RS
Sbjct: 269 EAEAYSRS 276
>NP_060729
          Length = 1141

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RDAEAYR 7
           RD++AYR
Sbjct: 487 RDSDAYR 493
>NP_872313
          Length = 452

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DAEAYRRS 9
           +AEAY RS
Sbjct: 269 EAEAYSRS 276
>XP_005268733
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DAEAYRRS 9
           +AEAY RS
Sbjct: 304 EAEAYSRS 311
>XP_005268732
          Length = 550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DAEAYRRS 9
           +AEAY RS
Sbjct: 367 EAEAYSRS 374
>XP_005253074
          Length = 956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RDAEAYR 7
           RD++AYR
Sbjct: 487 RDSDAYR 493
>XP_006718326
          Length = 968

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RDAEAYR 7
           RD++AYR
Sbjct: 257 RDSDAYR 263
>XP_005253073
          Length = 1198

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RDAEAYR 7
           RD++AYR
Sbjct: 487 RDSDAYR 493
>NP_061822
          Length = 389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RDAEAYRRS 9
           R A AYRRS
Sbjct: 233 RLARAYRRS 241
>NP_004387
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RDAEAYRRS 9
          ++ E YRRS
Sbjct: 71 QEVETYRRS 79
>NP_005245
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDAEAYRR 8
           ++AEAYR+
Sbjct: 373 QEAEAYRQ 380
>NP_057738
          Length = 383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDAEAYRR 8
           ++AEAYR+
Sbjct: 361 QEAEAYRQ 368
>XP_006721801
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RDAEAYRRS 9
          ++ E YRRS
Sbjct: 71 QEVETYRRS 79
>XP_005257168
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RDAEAYRRS 9
          ++ E YRRS
Sbjct: 71 QEVETYRRS 79
>XP_006720521
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDAEAYRR 8
           ++AEAYR+
Sbjct: 365 QEAEAYRQ 372
>XP_006720520
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDAEAYRR 8
           ++AEAYR+
Sbjct: 366 QEAEAYRQ 373
>XP_005254331
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDAEAYRR 8
           ++AEAYR+
Sbjct: 373 QEAEAYRQ 380
>XP_005254330
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDAEAYRR 8
           ++AEAYR+
Sbjct: 373 QEAEAYRQ 380
>XP_006720519
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDAEAYRR 8
           ++AEAYR+
Sbjct: 377 QEAEAYRQ 384
>XP_006720518
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RDAEAYRR 8
           ++AEAYR+
Sbjct: 378 QEAEAYRQ 385
>XP_005247407
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DAEAYRRS 9
          DA+ YRR+
Sbjct: 69 DAQEYRRA 76
>NP_001122318
          Length = 1616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>NP_001122320
          Length = 1613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>NP_001122321
          Length = 1679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>NP_001122317
          Length = 1617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>NP_003063
          Length = 1647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>NP_001122319
          Length = 1614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>NP_001122316
          Length = 1647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>NP_002787
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RDAEAYRR 8
           RDA +Y R
Sbjct: 224 RDARSYNR 231
>NP_001158109
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>NP_775898
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>NP_004215
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RDAEAYRRS 9
           R + AYR+S
Sbjct: 391 RSSSAYRKS 399
>NP_001158110
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>NP_114141
          Length = 5635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    RDAEAYR 7
            R+AE YR
Sbjct: 5598 REAETYR 5604
>NP_056081
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           DA+A+RR+
Sbjct: 478 DAKAHRRN 485
>NP_001247420
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           DA+A+RR+
Sbjct: 494 DAKAHRRN 501
>XP_006723821
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           DA+A+RR+
Sbjct: 231 DAKAHRRN 238
>XP_006723820
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           DA+A+RR+
Sbjct: 231 DAKAHRRN 238
>XP_006723819
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           DA+A+RR+
Sbjct: 511 DAKAHRRN 518
>XP_005260092
          Length = 1613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_005260091
          Length = 1614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_005260090
          Length = 1616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_005260089
          Length = 1617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_005260088
          Length = 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_005260087
          Length = 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_005260085
          Length = 1650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_006722910
          Length = 1678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_006722909
          Length = 1679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_006722908
          Length = 1679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DAEAYRRS 9
           +A+AY+RS
Sbjct: 435 NAKAYKRS 442
>XP_006721905
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>XP_005257303
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>XP_006721904
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>XP_006721903
          Length = 269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>XP_006721902
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>XP_006721901
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>XP_005257301
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>XP_006721900
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RDAEAYRR 8
          RD EA++R
Sbjct: 31 RDTEAWQR 38
>XP_006711533
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RDAEAYRRS 9
           RD E  RRS
Sbjct: 524 RDTEQLRRS 532
>XP_005245422
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RDAEAYRRS 9
           RD E  RRS
Sbjct: 524 RDTEQLRRS 532
>NP_065821
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RDAEAYRRS 9
           RD E  RRS
Sbjct: 524 RDTEQLRRS 532
>NP_055190
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  DAEAYRR 8
          DA+ YRR
Sbjct: 69 DAQEYRR 75
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.124    0.331 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 546,896
Number of extensions: 1150
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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