Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              18    1482
NP_005913                                                              18    1482
XP_005267046                                                           18    1482
XP_005267045                                                           18    1482
NP_001035351                                                           18    1935
NP_001035350                                                           18    1935
XP_005262843                                                           18    1935
XP_005262842                                                           18    1935
NP_001946                                                              17    4312
NP_001161791                                                           17    4312
NP_733793                                                              17    4312
NP_004832                                                              17    4312
NP_001181966                                                           17    4312
NP_001071174                                                           17    4312
NP_038475                                                              17    4312
NP_001257981                                                           17    4312
XP_005259943                                                           17    4312
XP_005259942                                                           17    4312
XP_005259941                                                           17    4312
XP_006715535                                                           17    4312
XP_005245679                                                           17    4312
XP_005245678                                                           17    4312
XP_005245677                                                           17    4312
XP_006711697                                                           17    4312
NP_003416                                                              16    5631
NP_002937                                                              16    5631
XP_005246719                                                           16    5631
XP_005246718                                                           16    5631
XP_005246022                                                           16    5631
NP_060556                                                              16    5631
NP_056467                                                              16    7355
NP_789789                                                              16    7355
NP_002323                                                              15    9605
NP_443728                                                              15    9605
NP_001257545                                                           15    9605
NP_002754                                                              15    9605
NP_510880                                                              15    9605
NP_005831                                                              15    9605
NP_976063                                                              15    9605
XP_005274857                                                           15    9605
XP_005274700                                                           15    9605
XP_005274699                                                           15    9605
XP_006713550                                                           15    9605
XP_006711518                                                           15    9605
XP_005273252                                                           15    9605
XP_005273253                                                           15    9605
XP_005273251                                                           15    9605
>NP_006715
          Length = 1558

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RCTASQLLD 9
            R TASQLLD
Sbjct: 1539 RWTASQLLD 1547
>NP_005913
          Length = 1608

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RCTASQLLD 9
            R TASQLLD
Sbjct: 1589 RWTASQLLD 1597
>XP_005267046
          Length = 1554

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RCTASQLLD 9
            R TASQLLD
Sbjct: 1535 RWTASQLLD 1543
>XP_005267045
          Length = 1604

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RCTASQLLD 9
            R TASQLLD
Sbjct: 1585 RWTASQLLD 1593
>NP_001035351
          Length = 783

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RCTASQLL 8
           RCTA Q+L
Sbjct: 656 RCTAGQIL 663
>NP_001035350
          Length = 766

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RCTASQLL 8
           RCTA Q+L
Sbjct: 639 RCTAGQIL 646
>XP_005262843
          Length = 765

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RCTASQLL 8
           RCTA Q+L
Sbjct: 638 RCTAGQIL 645
>XP_005262842
          Length = 782

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RCTASQLL 8
           RCTA Q+L
Sbjct: 655 RCTAGQIL 662
>NP_001946
          Length = 212

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RCTASQLLD 9
          RC+ S L+D
Sbjct: 52 RCSCSSLMD 60
>NP_001161791
          Length = 211

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RCTASQLLD 9
          RC+ S L+D
Sbjct: 51 RCSCSSLMD 59
>NP_733793
          Length = 1280

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RCTASQLLD 9
           +C++S+L+D
Sbjct: 562 KCSSSELID 570
>NP_004832
          Length = 1139

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RCTASQLLD 9
           +C++S+L+D
Sbjct: 414 KCSSSELID 422
>NP_001181966
          Length = 904

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  RCTASQL 7
          RCT SQL
Sbjct: 53 RCTKSQL 59
>NP_001071174
          Length = 904

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  RCTASQL 7
          RCT SQL
Sbjct: 53 RCTKSQL 59
>NP_038475
          Length = 823

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CTASQLLD 9
           C AS LLD
Sbjct: 328 CVASHLLD 335
>NP_001257981
          Length = 765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CTASQLLD 9
           C AS LLD
Sbjct: 328 CVASHLLD 335
>XP_005259943
          Length = 551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  CTASQLLD 9
          C AS LLD
Sbjct: 67 CVASHLLD 74
>XP_005259942
          Length = 834

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CTASQLLD 9
           C AS LLD
Sbjct: 397 CVASHLLD 404
>XP_005259941
          Length = 892

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CTASQLLD 9
           C AS LLD
Sbjct: 397 CVASHLLD 404
>XP_006715535
          Length = 946

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  RCTASQL 7
          RCT SQL
Sbjct: 53 RCTKSQL 59
>XP_005245679
          Length = 1142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RCTASQLLD 9
           +C++S+L+D
Sbjct: 414 KCSSSELID 422
>XP_005245678
          Length = 1145

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RCTASQLLD 9
           +C++S+L+D
Sbjct: 417 KCSSSELID 425
>XP_005245677
          Length = 1173

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RCTASQLLD 9
           +C++S+L+D
Sbjct: 445 KCSSSELID 453
>XP_006711697
          Length = 1179

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RCTASQLLD 9
           +C++S+L+D
Sbjct: 454 KCSSSELID 462
>NP_003416
          Length = 682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CTASQLLD 9
           C AS LLD
Sbjct: 398 CRASNLLD 405
>NP_002937
          Length = 270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  CTASQLL 8
          CT SQLL
Sbjct: 49 CTISQLL 55
>XP_005246719
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RCTASQL 7
           RC ASQL
Sbjct: 526 RCIASQL 532
>XP_005246718
          Length = 785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RCTASQL 7
           RC ASQL
Sbjct: 563 RCIASQL 569
>XP_005246022
          Length = 278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  CTASQLL 8
          CT SQLL
Sbjct: 57 CTISQLL 63
>NP_060556
          Length = 759

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RCTASQL 7
           RC ASQL
Sbjct: 537 RCIASQL 543
>NP_056467
          Length = 1247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RCTASQLLD 9
           RC  SQL D
Sbjct: 505 RCLRSQLSD 513
>NP_789789
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RCTASQLLD 9
           RC + +LLD
Sbjct: 174 RCPSQRLLD 182
>NP_002323
          Length = 4544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    CTASQLL 8
            CTASQ +
Sbjct: 3334 CTASQFV 3340
>NP_443728
          Length = 2145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RCTASQLLD 9
           RC  S++LD
Sbjct: 543 RCGESEVLD 551
>NP_001257545
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RCTASQLL 8
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>NP_002754
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RCTASQLL 8
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>NP_510880
          Length = 2054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TASQLLD 9
            +ASQLLD
Sbjct: 1307 SASQLLD 1313
>NP_005831
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASQLLD 9
           C+A  LLD
Sbjct: 176 CSAESLLD 183
>NP_976063
          Length = 2039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    TASQLLD 9
            +ASQLLD
Sbjct: 1307 SASQLLD 1313
>XP_005274857
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASQLLD 9
           C+A  LLD
Sbjct: 176 CSAESLLD 183
>XP_005274700
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASQLLD 9
           C+A  LLD
Sbjct: 176 CSAESLLD 183
>XP_005274699
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CTASQLLD 9
           C+A  LLD
Sbjct: 176 CSAESLLD 183
>XP_006713550
          Length = 2180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RCTASQLLD 9
           RC  S++LD
Sbjct: 543 RCGESEVLD 551
>XP_006711518
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RCTASQLL 8
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>XP_005273252
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RCTASQLL 8
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>XP_005273253
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RCTASQLL 8
           RC  SQL+
Sbjct: 614 RCITSQLI 621
>XP_005273251
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RCTASQLL 8
           RC  SQL+
Sbjct: 614 RCITSQLI 621
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.129    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 434,319
Number of extensions: 508
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package