Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001728                                                              18    1482
NP_689648                                                              17    3301
NP_940968                                                              17    4312
NP_060101                                                              17    4312
XP_006714536                                                           17    4312
NP_006715                                                              16    5631
NP_005913                                                              16    5631
NP_078907                                                              16    5631
XP_005271733                                                           16    5631
XP_006718971                                                           16    5631
XP_006718969                                                           16    5631
XP_006718968                                                           16    5631
XP_005271730                                                           16    5631
XP_005267046                                                           16    5631
XP_005267045                                                           16    5631
NP_057308                                                              16    7355
NP_694540                                                              16    7355
NP_789790                                                              16    7355
NP_001265552                                                           16    7355
NP_001265553                                                           16    7355
XP_005258905                                                           16    7355
XP_005267072                                                           16    7355
NP_899200                                                              15    9605
NP_003289                                                              15    9605
NP_005531                                                              15    9605
NP_079421                                                              15    9605
NP_001186571                                                           15    9605
NP_112489                                                              15    9605
NP_689966                                                              15    9605
XP_006718069                                                           15    9605
XP_005270233                                                           15    9605
XP_005270232                                                           15    9605
XP_005270230                                                           15    9605
XP_005270229                                                           15    9605
XP_005270228                                                           15    9605
XP_005249005                                                           15    9605
XP_005249004                                                           15    9605
XP_005249003                                                           15    9605
XP_005249000                                                           15    9605
XP_006713547                                                           15    9605
XP_006713546                                                           15    9605
XP_005247135                                                           15    9605
XP_005247134                                                           15    9605
XP_006713383                                                           15    9605
XP_005265485                                                           15    9605
XP_005270894                                                           15    9605
XP_006710684                                                           15    9605
XP_005270892                                                           15    9605
XP_005270890                                                           15    9605
XP_006710665                                                           15    9605
NP_848643                                                              15    9605
>NP_001728
          Length = 559

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RCIKMRM 7
           RCIKMR+
Sbjct: 111 RCIKMRL 117
>NP_689648
          Length = 426

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CIKMRMEM 9
           C+ MRM M
Sbjct: 352 CVNMRMSM 359
>NP_940968
          Length = 638

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C+KMR+ +
Sbjct: 420 CVKMRLSL 427
>NP_060101
          Length = 1712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   CIKMRMEM 9
           C+K+++EM
Sbjct: 634 CVKLQVEM 641
>XP_006714536
          Length = 524

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C+KMR+ +
Sbjct: 306 CVKMRLSL 313
>NP_006715
          Length = 1558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   CIKMRME 8
           C+K+R+E
Sbjct: 630 CLKLRLE 636
>NP_005913
          Length = 1608

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   CIKMRME 8
           C+K+R+E
Sbjct: 630 CLKLRLE 636
>NP_078907
          Length = 507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RCIKMRMEM 9
           RC+++ ME+
Sbjct: 332 RCLELHMEI 340
>XP_005271733
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RCIKMRMEM 9
           RC+++ ME+
Sbjct: 154 RCLELHMEI 162
>XP_006718971
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RCIKMRMEM 9
           RC+++ ME+
Sbjct: 154 RCLELHMEI 162
>XP_006718969
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RCIKMRMEM 9
           RC+++ ME+
Sbjct: 154 RCLELHMEI 162
>XP_006718968
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RCIKMRMEM 9
           RC+++ ME+
Sbjct: 154 RCLELHMEI 162
>XP_005271730
          Length = 648

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RCIKMRMEM 9
           RC+++ ME+
Sbjct: 473 RCLELHMEI 481
>XP_005267046
          Length = 1554

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   CIKMRME 8
           C+K+R+E
Sbjct: 630 CLKLRLE 636
>XP_005267045
          Length = 1604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   CIKMRME 8
           C+K+R+E
Sbjct: 630 CLKLRLE 636
>NP_057308
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IKMRME 8
           IKMRME
Sbjct: 324 IKMRME 329
>NP_694540
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   RCIKMR 6
           +C+KMR
Sbjct: 469 KCVKMR 474
>NP_789790
          Length = 991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIKMRME 8
           C+K R+E
Sbjct: 346 CVKQRLE 352
>NP_001265552
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   RCIKMR 6
           +C+KMR
Sbjct: 469 KCVKMR 474
>NP_001265553
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   RCIKMR 6
           +C+KMR
Sbjct: 469 KCVKMR 474
>XP_005258905
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIKMRME 8
           C+K R+E
Sbjct: 255 CVKQRLE 261
>XP_005267072
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IKMRME 8
           IKMRME
Sbjct: 317 IKMRME 322
>NP_899200
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C++M M+M
Sbjct: 537 CVEMGMDM 544
>NP_003289
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RCIKMRMEM 9
           +C++M M+M
Sbjct: 195 KCLEMGMKM 203
>NP_005531
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RCIKMRMEM 9
           RC ++ +EM
Sbjct: 148 RCAELELEM 156
>NP_079421
          Length = 1665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C+K+R E+
Sbjct: 934 CLKLRKEI 941
>NP_001186571
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C++M M+M
Sbjct: 187 CVEMGMDM 194
>NP_112489
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIKMRME 8
           C+K RM+
Sbjct: 95  CVKTRMQ 101
>NP_689966
          Length = 993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIKMRME 8
           C++ RME
Sbjct: 571 CLRQRME 577
>XP_006718069
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIKMRME 8
           C+K RM+
Sbjct: 95  CVKTRMQ 101
>XP_005270233
          Length = 927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C+K+R E+
Sbjct: 196 CLKLRKEI 203
>XP_005270232
          Length = 1535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C+K+R E+
Sbjct: 935 CLKLRKEI 942
>XP_005270230
          Length = 1627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C+K+R E+
Sbjct: 896 CLKLRKEI 903
>XP_005270229
          Length = 1637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C+K+R E+
Sbjct: 935 CLKLRKEI 942
>XP_005270228
          Length = 1666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C+K+R E+
Sbjct: 935 CLKLRKEI 942
>XP_005249005
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIKMRME 8
           C++ RME
Sbjct: 109 CLRQRME 115
>XP_005249004
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIKMRME 8
           C++ RME
Sbjct: 587 CLRQRME 593
>XP_005249003
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIKMRME 8
           C++ RME
Sbjct: 565 CLRQRME 571
>XP_005249000
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIKMRME 8
           C++ RME
Sbjct: 587 CLRQRME 593
>XP_006713547
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C++M M+M
Sbjct: 96  CVEMGMDM 103
>XP_006713546
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C++M M+M
Sbjct: 170 CVEMGMDM 177
>XP_005247135
          Length = 936

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C++M M+M
Sbjct: 187 CVEMGMDM 194
>XP_005247134
          Length = 1286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIKMRMEM 9
           C++M M+M
Sbjct: 537 CVEMGMDM 544
>XP_006713383
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RCIKMRMEM 9
           +C++M M+M
Sbjct: 195 KCLEMGMKM 203
>XP_005265485
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RCIKMRMEM 9
           +C++M M+M
Sbjct: 176 KCLEMGMKM 184
>XP_005270894
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RCIKMRMEM 9
           RC ++ +EM
Sbjct: 148 RCAELELEM 156
>XP_006710684
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  RCIKMRMEM 9
          RC ++ +EM
Sbjct: 29 RCAELELEM 37
>XP_005270892
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RCIKMRMEM 9
           RC ++ +EM
Sbjct: 148 RCAELELEM 156
>XP_005270890
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RCIKMRMEM 9
           RC ++ +EM
Sbjct: 146 RCAELELEM 154
>XP_006710665
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   RCIKMRME 8
           RC++ R+E
Sbjct: 307 RCLRERLE 314
>NP_848643
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   RCIKMRME 8
           RC++ R+E
Sbjct: 270 RCLRERLE 277
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.351    0.140    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 475,930
Number of extensions: 622
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.0 bits)
S2: 28 (15.4 bits)

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