Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     869
XP_006716142                                                           19     869
XP_005250088                                                           19     869
XP_006716141                                                           19     869
XP_005250085                                                           19     869
XP_006716140                                                           19     869
XP_005250084                                                           19     869
XP_005250083                                                           19     869
XP_005250082                                                           19     869
NP_001166902                                                           17    4312
NP_056126                                                              17    4312
NP_001166879                                                           17    4312
NP_065883                                                              17    4312
NP_056261                                                              17    4312
XP_005246484                                                           17    4312
XP_005246482                                                           17    4312
XP_005246481                                                           17    4312
XP_006712450                                                           17    4312
XP_005246480                                                           17    4312
XP_006712449                                                           17    4312
XP_005246478                                                           17    4312
XP_006711822                                                           17    4312
XP_006711821                                                           17    4312
XP_005245423                                                           17    4312
XP_005245425                                                           17    4312
NP_079040                                                              16    5631
NP_114437                                                              16    7355
NP_068767                                                              16    7355
NP_775960                                                              16    7355
NP_055386                                                              16    7355
XP_005251991                                                           16    7355
XP_005270802                                                           16    7355
NP_940819                                                              16    7355
NP_001243643                                                           15    9605
NP_001164434                                                           15    9605
NP_001171562                                                           15    9605
NP_005495                                                              15    9605
NP_001171564                                                           15    9605
NP_001171565                                                           15    9605
NP_001171563                                                           15    9605
NP_001191433                                                           15    9605
NP_821077                                                              15    9605
NP_001191435                                                           15    9605
NP_001191434                                                           15    9605
NP_690874                                                              15    9605
NP_006217                                                              15    9605
NP_001271254                                                           15    9605
NP_001181                                                              15    9605
NP_001158245                                                           15    9605
NP_991402                                                              15    9605
XP_005266328                                                           15    9605
XP_005253517                                                           15    9605
XP_005246701                                                           15    9605
XP_005246700                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           AVVLPGVS
Sbjct: 918 AVVLPGVS 925
>XP_006716142
          Length = 4927

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           AVVLPGVS
Sbjct: 919 AVVLPGVS 926
>XP_005250088
          Length = 4928

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           AVVLPGVS
Sbjct: 919 AVVLPGVS 926
>XP_006716141
          Length = 4959

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           AVVLPGVS
Sbjct: 919 AVVLPGVS 926
>XP_005250085
          Length = 4979

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           AVVLPGVS
Sbjct: 919 AVVLPGVS 926
>XP_006716140
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           AVVLPGVS
Sbjct: 919 AVVLPGVS 926
>XP_005250084
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           AVVLPGVS
Sbjct: 919 AVVLPGVS 926
>XP_005250083
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           AVVLPGVS
Sbjct: 918 AVVLPGVS 925
>XP_005250082
          Length = 4983

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           AVVLPGVS
Sbjct: 919 AVVLPGVS 926
>NP_001166902
          Length = 1543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>NP_056126
          Length = 1896

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>NP_001166879
          Length = 1025

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>NP_065883
          Length = 1237

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RAVVLPG 7
           +AVVLPG
Sbjct: 422 KAVVLPG 428
>NP_056261
          Length = 2275

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RAVVLPG 7
           +AVVLPG
Sbjct: 127 KAVVLPG 133
>XP_005246484
          Length = 1359

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>XP_005246482
          Length = 1724

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>XP_005246481
          Length = 1804

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>XP_006712450
          Length = 1816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>XP_005246480
          Length = 1816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>XP_006712449
          Length = 1908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>XP_005246478
          Length = 1908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AVVLPGVS 9
           A+VLPGV+
Sbjct: 481 ALVLPGVT 488
>XP_006711822
          Length = 2266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RAVVLPG 7
           +AVVLPG
Sbjct: 118 KAVVLPG 124
>XP_006711821
          Length = 2301

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RAVVLPG 7
           +AVVLPG
Sbjct: 153 KAVVLPG 159
>XP_005245423
          Length = 1246

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RAVVLPG 7
           +AVVLPG
Sbjct: 431 KAVVLPG 437
>XP_005245425
          Length = 1299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RAVVLPG 7
           +AVVLPG
Sbjct: 484 KAVVLPG 490
>NP_079040
          Length = 1116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAVVLPGVS 9
           + VVLPG S
Sbjct: 656 KTVVLPGYS 664
>NP_114437
          Length = 1053

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AVVLPGVS 9
           A  LPGVS
Sbjct: 521 AAALPGVS 528
>NP_068767
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAVVLPGVS 9
           RAV+ PG S
Sbjct: 512 RAVLQPGAS 520
>NP_775960
          Length = 1285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AVVLPG 7
           AVVLPG
Sbjct: 714 AVVLPG 719
>NP_055386
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VLPGVS 9
           VLPGVS
Sbjct: 203 VLPGVS 208
>XP_005251991
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AVVLPG 7
           AVVLPG
Sbjct: 382 AVVLPG 387
>XP_005270802
          Length = 300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VLPGVS 9
           VLPGVS
Sbjct: 175 VLPGVS 180
>NP_940819
          Length = 671

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAVVLPGVS 9
           RAV+ PG S
Sbjct: 512 RAVLQPGAS 520
>NP_001243643
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AVVLPG 7
          AV+LPG
Sbjct: 92 AVILPG 97
>NP_001164434
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AVVLPGV 8
           A+V+PG+
Sbjct: 233 AIVVPGI 239
>NP_001171562
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VVLPGVS 9
           ++LPGV+
Sbjct: 247 IILPGVT 253
>NP_005495
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VVLPGVS 9
           ++LPGV+
Sbjct: 284 IILPGVT 290
>NP_001171564
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VVLPGVS 9
           ++LPGV+
Sbjct: 296 IILPGVT 302
>NP_001171565
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VVLPGVS 9
           ++LPGV+
Sbjct: 283 IILPGVT 289
>NP_001171563
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VVLPGVS 9
           ++LPGV+
Sbjct: 223 IILPGVT 229
>NP_001191433
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVVLPGVS 9
           A VLPG+S
Sbjct: 568 APVLPGLS 575
>NP_821077
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVVLPGVS 9
           A VLPG+S
Sbjct: 568 APVLPGLS 575
>NP_001191435
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVVLPGVS 9
           A VLPG+S
Sbjct: 432 APVLPGLS 439
>NP_001191434
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVVLPGVS 9
           A VLPG+S
Sbjct: 432 APVLPGLS 439
>NP_690874
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVVLPGVS 9
           A VLPG+S
Sbjct: 568 APVLPGLS 575
>NP_006217
          Length = 1095

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VLPGVS 9
           +LPGVS
Sbjct: 714 ILPGVS 719
>NP_001271254
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVLPGV 8
           V+LPGV
Sbjct: 251 VILPGV 256
>NP_001181
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVLPGV 8
           V+LPGV
Sbjct: 291 VILPGV 296
>NP_001158245
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VVLPGV 8
           V+LPGV
Sbjct: 199 VILPGV 204
>NP_991402
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   AVVLPGV 8
           A+V+PG+
Sbjct: 233 AIVVPGI 239
>XP_005266328
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVVLPGVS 9
           A VLPG+S
Sbjct: 323 APVLPGLS 330
>XP_005253517
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VVLPGVS 9
           ++LPGV+
Sbjct: 283 IILPGVT 289
>XP_005246701
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VLPGVS 9
           +LPGVS
Sbjct: 635 ILPGVS 640
>XP_005246700
          Length = 1021

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VLPGVS 9
           +LPGVS
Sbjct: 640 ILPGVS 645
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.140    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 725,775
Number of extensions: 758
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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