Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_061184                                                              18    1135
NP_005350                                                              17    3301
NP_005600                                                              17    4312
NP_001158188                                                           17    4312
NP_002842                                                              17    4312
NP_001193767                                                           17    4312
XP_006716139                                                           17    4312
XP_005250576                                                           17    4312
NP_001193768                                                           17    4312
NP_001189489                                                           16    5631
NP_059998                                                              16    5631
XP_006715911                                                           16    5631
XP_006715910                                                           16    5631
NP_061985                                                              16    7355
NP_001123572                                                           16    7355
NP_001123571                                                           16    7355
NP_005541                                                              16    7355
NP_055335                                                              16    7355
NP_001099008                                                           16    7355
XP_006722680                                                           16    7355
XP_006722679                                                           16    7355
XP_006721482                                                           16    7355
XP_005256470                                                           16    7355
XP_006721253                                                           16    7355
XP_005256003                                                           16    7355
XP_005256002                                                           16    7355
XP_005256001                                                           16    7355
XP_006721252                                                           16    7355
XP_005256000                                                           16    7355
XP_005255994                                                           16    7355
XP_006721251                                                           16    7355
NP_066264                                                              15    9605
NP_001136401                                                           15    9605
NP_065574                                                              15    9605
NP_001136405                                                           15    9605
NP_001136406                                                           15    9605
NP_066266                                                              15    9605
NP_066265                                                              15    9605
NP_006280                                                              15    9605
NP_001276332                                                           15    9605
NP_001276334                                                           15    9605
NP_071757                                                              15    9605
NP_060395                                                              15    9605
NP_001077081                                                           15    9605
NP_001013641                                                           15    9605
NP_001248755                                                           15    9605
NP_003929                                                              15    9605
NP_061740                                                              15    9605
NP_114442                                                              15    9605
NP_112587                                                              15    9605
XP_006722995                                                           15    9605
XP_006718007                                                           15    9605
XP_006716915                                                           15    9605
XP_005251621                                                           15    9605
XP_006716870                                                           15    9605
XP_006716869                                                           15    9605
XP_006716868                                                           15    9605
XP_006716867                                                           15    9605
NP_001123475                                                           15    9605
>NP_061184
          Length = 980

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   RALQLLYEV 9
           RALQLLY++
Sbjct: 805 RALQLLYDL 813
>NP_005350
          Length = 552

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RALQLL EV
Sbjct: 531 RALQLLDEV 539
>NP_005600
          Length = 842

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           R LQ++YE+
Sbjct: 399 RHLQIIYEI 407
>NP_001158188
          Length = 754

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           R LQ++YE+
Sbjct: 311 RHLQIIYEI 319
>NP_002842
          Length = 2315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RAL +L+EV
Sbjct: 177 RALSILFEV 185
>NP_001193767
          Length = 1455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RAL +L+EV
Sbjct: 177 RALSILFEV 185
>XP_006716139
          Length = 1869

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RAL +L+EV
Sbjct: 177 RALSILFEV 185
>XP_005250576
          Length = 2308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RAL +L+EV
Sbjct: 177 RALSILFEV 185
>NP_001193768
          Length = 1448

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RAL +L+EV
Sbjct: 177 RALSILFEV 185
>NP_001189489
          Length = 298

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RALQLLY 7
          RAL+LLY
Sbjct: 42 RALELLY 48
>NP_059998
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RALQLLY 7
          RAL+LLY
Sbjct: 42 RALELLY 48
>XP_006715911
          Length = 250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RALQLLY 7
          RAL+LLY
Sbjct: 11 RALELLY 17
>XP_006715910
          Length = 304

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RALQLLY 7
          RAL+LLY
Sbjct: 65 RALELLY 71
>NP_061985
          Length = 2146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RALQLLYE 8
           RALQLL E
Sbjct: 424 RALQLLAE 431
>NP_001123572
          Length = 826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 550 RALQLLF 556
>NP_001123571
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 411 RALQLLF 417
>NP_005541
          Length = 833

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 550 RALQLLF 556
>NP_055335
          Length = 1328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RALQL+ +V
Sbjct: 684 RALQLILDV 692
>NP_001099008
          Length = 1332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RALQL+ +V
Sbjct: 684 RALQLILDV 692
>XP_006722680
          Length = 1636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RALQLLYE 8
           RALQLL E
Sbjct: 424 RALQLLAE 431
>XP_006722679
          Length = 2128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RALQLLYE 8
           RALQLL E
Sbjct: 424 RALQLLAE 431
>XP_006721482
          Length = 723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RALQL+ +V
Sbjct: 684 RALQLILDV 692
>XP_005256470
          Length = 1120

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RALQLLYEV 9
           RALQL+ +V
Sbjct: 684 RALQLILDV 692
>XP_006721253
          Length = 828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 545 RALQLLF 551
>XP_005256003
          Length = 768

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 492 RALQLLF 498
>XP_005256002
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 493 RALQLLF 499
>XP_005256001
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 492 RALQLLF 498
>XP_006721252
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 492 RALQLLF 498
>XP_005256000
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 493 RALQLLF 499
>XP_005255994
          Length = 996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 713 RALQLLF 719
>XP_006721251
          Length = 1022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 739 RALQLLF 745
>NP_066264
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 285 RALQLLH 291
>NP_001136401
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 285 RALQLLH 291
>NP_065574
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 403 RALQLLH 409
>NP_001136405
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 321 RALQLLH 327
>NP_001136406
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 285 RALQLLH 291
>NP_066266
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 285 RALQLLH 291
>NP_066265
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RALQLLY 7
           RALQLL+
Sbjct: 285 RALQLLH 291
>NP_006280
          Length = 2541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ALQLLY 7
            ALQLLY
Sbjct: 1772 ALQLLY 1777
>NP_001276332
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RALQLLYEV 9
          RA+QLL +V
Sbjct: 67 RAIQLLSQV 75
>NP_001276334
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RALQLLYEV 9
          RA+QLL +V
Sbjct: 67 RAIQLLSQV 75
>NP_071757
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RALQLLYEV 9
          RA+QLL +V
Sbjct: 67 RAIQLLSQV 75
>NP_060395
          Length = 1909

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RALQLLYEV 9
           RALQ  Y+V
Sbjct: 798 RALQQAYDV 806
>NP_001077081
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLLYEV 9
           QLLYE+
Sbjct: 142 QLLYEI 147
>NP_001013641
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLLYEV 9
           QLLYE+
Sbjct: 142 QLLYEI 147
>NP_001248755
          Length = 1215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RALQLLY 7
           RAL LLY
Sbjct: 359 RALDLLY 365
>NP_003929
          Length = 1153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RALQLLY 7
           RAL LLY
Sbjct: 359 RALDLLY 365
>NP_061740
          Length = 962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RALQLLYEV 9
          RA Q+LY V
Sbjct: 58 RAEQILYSV 66
>NP_114442
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RALQLLYEV 9
          RA Q+LY V
Sbjct: 58 RAEQILYSV 66
>NP_112587
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RALQLLYE 8
           + LQ+LYE
Sbjct: 169 QCLQILYE 176
>XP_006722995
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RALQLLY 7
           RAL LLY
Sbjct: 359 RALDLLY 365
>XP_006718007
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RALQLLYEV 9
          RA+QLL +V
Sbjct: 88 RAIQLLSQV 96
>XP_006716915
          Length = 2542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ALQLLY 7
            ALQLLY
Sbjct: 1772 ALQLLY 1777
>XP_005251621
          Length = 2542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ALQLLY 7
            ALQLLY
Sbjct: 1772 ALQLLY 1777
>XP_006716870
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RALQLLYEV 9
           RALQ  Y+V
Sbjct: 296 RALQQAYDV 304
>XP_006716869
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RALQLLYEV 9
           RALQ  Y+V
Sbjct: 562 RALQQAYDV 570
>XP_006716868
          Length = 1894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RALQLLYEV 9
           RALQ  Y+V
Sbjct: 798 RALQQAYDV 806
>XP_006716867
          Length = 1958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RALQLLYEV 9
           RALQ  Y+V
Sbjct: 798 RALQQAYDV 806
>NP_001123475
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RALQLLYEV 9
          RAL+LL+ +
Sbjct: 24 RALELLFAI 32
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.146    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 420,405
Number of extensions: 564
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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