Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              18    1935
NP_006026                                                              17    2528
XP_005268287                                                           17    2528
XP_005268286                                                           17    2528
XP_005268285                                                           17    2528
XP_005268284                                                           17    2528
NP_067629                                                              17    3301
NP_065761                                                              17    3301
NP_569074                                                              17    3301
NP_001003827                                                           17    3301
NP_001003819                                                           17    3301
NP_001157968                                                           17    4312
XP_005247674                                                           17    4312
XP_006713761                                                           17    4312
XP_006713760                                                           17    4312
XP_006713759                                                           17    4312
NP_055855                                                              16    5631
NP_001075019                                                           16    5631
XP_006724836                                                           16    5631
XP_005262507                                                           16    5631
XP_006724835                                                           16    5631
XP_006724834                                                           16    5631
XP_006724833                                                           16    5631
XP_006724832                                                           16    5631
XP_006724831                                                           16    5631
XP_006724830                                                           16    5631
XP_005262504                                                           16    5631
XP_006712426                                                           16    5631
XP_006712425                                                           16    5631
XP_006712424                                                           16    5631
NP_071372                                                              16    7355
NP_001135445                                                           16    7355
NP_060555                                                              16    7355
NP_588614                                                              16    7355
NP_112593                                                              16    7355
XP_005258418                                                           16    7355
XP_006722617                                                           16    7355
XP_005258415                                                           16    7355
XP_005258414                                                           16    7355
XP_005272299                                                           16    7355
NP_060606                                                              15    9605
NP_001035203                                                           15    9605
NP_074035                                                              15    9605
NP_001035202                                                           15    9605
NP_002465                                                              15    9605
NP_149043                                                              15    9605
NP_001139281                                                           15    9605
NP_056053                                                              15    9605
NP_056052                                                              15    9605
NP_008949                                                              15    9605
NP_006715                                                              15    9605
NP_001070654                                                           15    9605
NP_005913                                                              15    9605
NP_079005                                                              15    9605
NP_001155134                                                           15    9605
NP_001155133                                                           15    9605
XP_003960647                                                           15    9605
XP_006723449                                                           15    9605
XP_003403507                                                           15    9605
XP_006717006                                                           15    9605
XP_006717005                                                           15    9605
XP_005251736                                                           15    9605
XP_005267046                                                           15    9605
XP_005267045                                                           15    9605
XP_006714899                                                           15    9605
XP_005265910                                                           15    9605
XP_006714898                                                           15    9605
XP_005265909                                                           15    9605
XP_005265908                                                           15    9605
XP_005265907                                                           15    9605
>NP_004295
          Length = 1620

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RAKQLVREL 9
           RAKQLV EL
Sbjct: 137 RAKQLVLEL 145
>NP_006026
          Length = 1711

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RAKQLVRE 8
           RAKQLV+E
Sbjct: 888 RAKQLVQE 895
>XP_005268287
          Length = 1490

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RAKQLVRE 8
           RAKQLV+E
Sbjct: 888 RAKQLVQE 895
>XP_005268286
          Length = 1685

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RAKQLVRE 8
           RAKQLV+E
Sbjct: 888 RAKQLVQE 895
>XP_005268285
          Length = 1702

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RAKQLVRE 8
           RAKQLV+E
Sbjct: 888 RAKQLVQE 895
>XP_005268284
          Length = 1728

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RAKQLVRE 8
           RAKQLV+E
Sbjct: 888 RAKQLVQE 895
>NP_067629
          Length = 488

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KQLVREL 9
           KQLVREL
Sbjct: 227 KQLVREL 233
>NP_065761
          Length = 583

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   RAKQLVREL 9
           +AK+LVR+L
Sbjct: 408 KAKELVRQL 416
>NP_569074
          Length = 270

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KQLVREL 9
           KQLVREL
Sbjct: 227 KQLVREL 233
>NP_001003827
          Length = 488

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KQLVREL 9
           KQLVREL
Sbjct: 227 KQLVREL 233
>NP_001003819
          Length = 842

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   KQLVREL 9
           KQLVREL
Sbjct: 581 KQLVREL 587
>NP_001157968
          Length = 1854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RAKQLVRE 8
            R KQL+RE
Sbjct: 1676 RRKQLIRE 1683
>XP_005247674
          Length = 1089

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RAKQLVRE 8
           R KQL+RE
Sbjct: 911 RRKQLIRE 918
>XP_006713761
          Length = 1554

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RAKQLVRE 8
            R KQL+RE
Sbjct: 1376 RRKQLIRE 1383
>XP_006713760
          Length = 1847

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RAKQLVRE 8
            R KQL+RE
Sbjct: 1669 RRKQLIRE 1676
>XP_006713759
          Length = 1898

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RAKQLVRE 8
            R KQL+RE
Sbjct: 1720 RRKQLIRE 1727
>NP_055855
          Length = 2098

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RAKQLVREL 9
            R KQL+R+L
Sbjct: 1102 RKKQLLRDL 1110
>NP_001075019
          Length = 1593

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_006724836
          Length = 1582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_005262507
          Length = 1594

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_006724835
          Length = 1615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_006724834
          Length = 1615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_006724833
          Length = 1620

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_006724832
          Length = 1640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_006724831
          Length = 1640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_006724830
          Length = 1642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_005262504
          Length = 1642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AKQLVREL 9
           AKQ+VR+L
Sbjct: 306 AKQIVRKL 313
>XP_006712426
          Length = 1237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RAKQLVREL 9
           R KQL+R+L
Sbjct: 408 RKKQLLRDL 416
>XP_006712425
          Length = 1349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RAKQLVREL 9
           R KQL+R+L
Sbjct: 408 RKKQLLRDL 416
>XP_006712424
          Length = 1376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RAKQLVREL 9
           R KQL+R+L
Sbjct: 408 RKKQLLRDL 416
>NP_071372
          Length = 1180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL REL
Sbjct: 1158 RFKQLEREL 1166
>NP_001135445
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL REL
Sbjct: 1153 RFKQLEREL 1161
>NP_060555
          Length = 1041

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RAKQLVREL 9
           RAK ++REL
Sbjct: 104 RAKIVIREL 112
>NP_588614
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RAKQLVRE 8
           +AK+L+RE
Sbjct: 562 KAKKLIRE 569
>NP_112593
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AKQLVRE 8
           AKQLV+E
Sbjct: 190 AKQLVKE 196
>XP_005258418
          Length = 427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AKQLVRE 8
           AKQLV+E
Sbjct: 151 AKQLVKE 157
>XP_006722617
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AKQLVRE 8
           AKQLV+E
Sbjct: 262 AKQLVKE 268
>XP_005258415
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AKQLVRE 8
           AKQLV+E
Sbjct: 287 AKQLVKE 293
>XP_005258414
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AKQLVRE 8
           AKQLV+E
Sbjct: 288 AKQLVKE 294
>XP_005272299
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  AKQLVREL 9
          A QLVREL
Sbjct: 71 ALQLVREL 78
>NP_060606
          Length = 3477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RAKQLVRE 8
            +A+QL+RE
Sbjct: 2545 KARQLLRE 2552
>NP_001035203
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL R+L
Sbjct: 1885 RVKQLKRQL 1893
>NP_074035
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL R+L
Sbjct: 1878 RVKQLKRQL 1886
>NP_001035202
          Length = 1945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL R+L
Sbjct: 1885 RVKQLKRQL 1893
>NP_002465
          Length = 1972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL R+L
Sbjct: 1878 RVKQLKRQL 1886
>NP_149043
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RAKQLVREL 9
           RA+QLV+ +
Sbjct: 796 RARQLVKNI 804
>NP_001139281
          Length = 2036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL R+L
Sbjct: 1936 RVKQLKRQL 1944
>NP_056053
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKQLVREL 9
           +  QLVREL
Sbjct: 401 KRNQLVREL 409
>NP_056052
          Length = 1354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RAKQLVRE 8
            R++QL+RE
Sbjct: 1107 RSRQLLRE 1114
>NP_008949
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    RAKQLVREL 9
            RA++L++EL
Sbjct: 2118 RARRLMKEL 2126
>NP_006715
          Length = 1558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQLVRE 8
           KQLVRE
Sbjct: 649 KQLVRE 654
>NP_001070654
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL R+L
Sbjct: 1903 RVKQLKRQL 1911
>NP_005913
          Length = 1608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQLVRE 8
           KQLVRE
Sbjct: 649 KQLVRE 654
>NP_079005
          Length = 1995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL R+L
Sbjct: 1895 RVKQLKRQL 1903
>NP_001155134
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKQLVREL 9
           +  QLVREL
Sbjct: 401 KRNQLVREL 409
>NP_001155133
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKQLVREL 9
           +  QLVREL
Sbjct: 401 KRNQLVREL 409
>XP_003960647
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  KQLVREL 9
          +QLVREL
Sbjct: 72 QQLVREL 78
>XP_006723449
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RAKQLVREL 9
            R KQL R+L
Sbjct: 1903 RVKQLKRQL 1911
>XP_003403507
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  KQLVREL 9
          +QLVREL
Sbjct: 72 QQLVREL 78
>XP_006717006
          Length = 1760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    RAKQLVREL 9
            RA++L++EL
Sbjct: 1553 RARRLMKEL 1561
>XP_006717005
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    RAKQLVREL 9
            RA++L++EL
Sbjct: 1581 RARRLMKEL 1589
>XP_005251736
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    RAKQLVREL 9
            RA++L++EL
Sbjct: 2118 RARRLMKEL 2126
>XP_005267046
          Length = 1554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQLVRE 8
           KQLVRE
Sbjct: 649 KQLVRE 654
>XP_005267045
          Length = 1604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQLVRE 8
           KQLVRE
Sbjct: 649 KQLVRE 654
>XP_006714899
          Length = 881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKQLVREL 9
           +  QLVREL
Sbjct: 158 KRNQLVREL 166
>XP_005265910
          Length = 1112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKQLVREL 9
           +  QLVREL
Sbjct: 401 KRNQLVREL 409
>XP_006714898
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKQLVREL 9
           +  QLVREL
Sbjct: 401 KRNQLVREL 409
>XP_005265909
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKQLVREL 9
           +  QLVREL
Sbjct: 401 KRNQLVREL 409
>XP_005265908
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKQLVREL 9
           +  QLVREL
Sbjct: 401 KRNQLVREL 409
>XP_005265907
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RAKQLVREL 9
           +  QLVREL
Sbjct: 401 KRNQLVREL 409
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.137    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 384,592
Number of extensions: 1050
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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