Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           20     299
NP_004561                                                              20     299
NP_001275703                                                           20     299
XP_005253450                                                           20     299
XP_006719151                                                           20     299
NP_064502                                                              18    1135
NP_612201                                                              17    2528
XP_006721798                                                           17    2528
XP_006721797                                                           17    2528
XP_006721796                                                           17    2528
NP_848658                                                              17    3301
XP_006716025                                                           17    3301
XP_006716024                                                           17    3301
NP_001074001                                                           16    5631
NP_001122306                                                           16    7355
NP_000524                                                              16    7355
NP_955772                                                              16    7355
NP_116244                                                              16    7355
NP_005698                                                              16    7355
XP_005254165                                                           16    7355
NP_001106849                                                           15    9605
NP_060663                                                              15    9605
NP_065194                                                              15    9605
NP_056144                                                              15    9605
NP_036346                                                              15    9605
NP_001153626                                                           15    9605
NP_001258769                                                           15    9605
NP_055506                                                              15    9605
NP_008845                                                              15    9605
NP_079439                                                              15    9605
XP_006722774                                                           15    9605
XP_005259895                                                           15    9605
XP_005259894                                                           15    9605
XP_006718010                                                           15    9605
XP_006713821                                                           15    9605
NP_001005289                                                           15    9605
>NP_001275701
          Length = 1486

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    YLIQVTHS 9
            YLIQVTHS
Sbjct: 1262 YLIQVTHS 1269
>NP_004561
          Length = 1445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    YLIQVTHS 9
            YLIQVTHS
Sbjct: 1221 YLIQVTHS 1228
>NP_001275703
          Length = 1264

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    YLIQVTHS 9
            YLIQVTHS
Sbjct: 1040 YLIQVTHS 1047
>XP_005253450
          Length = 1486

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    YLIQVTHS 9
            YLIQVTHS
Sbjct: 1262 YLIQVTHS 1269
>XP_006719151
          Length = 1486

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    YLIQVTHS 9
            YLIQVTHS
Sbjct: 1262 YLIQVTHS 1269
>NP_064502
          Length = 1176

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   QYLIQVTH 8
           QYL++VTH
Sbjct: 900 QYLMEVTH 907
>NP_612201
          Length = 404

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QYLIQVTH 8
           Q+++QVTH
Sbjct: 186 QFVLQVTH 193
>XP_006721798
          Length = 268

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  QYLIQVTH 8
          Q+++QVTH
Sbjct: 50 QFVLQVTH 57
>XP_006721797
          Length = 362

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QYLIQVTH 8
           Q+++QVTH
Sbjct: 144 QFVLQVTH 151
>XP_006721796
          Length = 396

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QYLIQVTH 8
           Q+++QVTH
Sbjct: 178 QFVLQVTH 185
>NP_848658
          Length = 920

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QYLIQVTHS 9
           QYL+ + HS
Sbjct: 749 QYLLPIVHS 757
>XP_006716025
          Length = 920

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QYLIQVTHS 9
           QYL+ + HS
Sbjct: 749 QYLLPIVHS 757
>XP_006716024
          Length = 920

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QYLIQVTHS 9
           QYL+ + HS
Sbjct: 749 QYLLPIVHS 757
>NP_001074001
          Length = 1100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/9 (88%), Positives = 8/9 (88%), Gaps = 1/9 (11%)

Query: 1    QYLIQVTHS 9
            QYL QVTHS
Sbjct: 1059 QYL-QVTHS 1066
>NP_001122306
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QYLIQVTHS 9
          +YLI V H+
Sbjct: 59 EYLINVIHA 67
>NP_000524
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QYLIQVTHS 9
          +YLI V H+
Sbjct: 59 EYLINVIHA 67
>NP_955772
          Length = 242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QYLIQVTHS 9
          +YLI V H+
Sbjct: 59 EYLINVIHA 67
>NP_116244
          Length = 352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  YLIQVTHS 9
          +LI+V+HS
Sbjct: 56 FLIRVSHS 63
>NP_005698
          Length = 485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QYLIQVTHS 9
           QY +Q  HS
Sbjct: 429 QYYLQAEHS 437
>XP_005254165
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QYLIQVTHS 9
           QY +Q  HS
Sbjct: 350 QYYLQAEHS 358
>NP_001106849
          Length = 1328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYLIQVT 7
           QY+IQ+T
Sbjct: 172 QYVIQLT 178
>NP_060663
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QYLIQVT 7
           QY+IQ+T
Sbjct: 172 QYVIQLT 178
>NP_065194
          Length = 1819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QYLIQVTH 8
           +++IQV H
Sbjct: 551 EFMIQVNH 558
>NP_056144
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YLIQVTHS 9
           YL+ V HS
Sbjct: 293 YLVTVMHS 300
>NP_036346
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YLIQVTHS 9
           YLI+  HS
Sbjct: 151 YLIETLHS 158
>NP_001153626
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YLIQVTHS 9
          YLI+  HS
Sbjct: 23 YLIETLHS 30
>NP_001258769
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  QYLIQVTH 8
          +YL Q TH
Sbjct: 17 EYLTQQTH 24
>NP_055506
          Length = 1485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    YLIQVTH 8
            +LIQ TH
Sbjct: 1371 HLIQTTH 1377
>NP_008845
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QYLIQVTHS 9
           Q  IQ+TH+
Sbjct: 261 QCAIQITHA 269
>NP_079439
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QYLIQVTHS 9
           +YL QV H+
Sbjct: 440 EYLEQVVHA 448
>XP_006722774
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YLIQVTHS 9
           YL+ V HS
Sbjct: 332 YLVTVMHS 339
>XP_005259895
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YLIQVTHS 9
           YL+ V HS
Sbjct: 304 YLVTVMHS 311
>XP_005259894
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YLIQVTHS 9
           YL+ V HS
Sbjct: 332 YLVTVMHS 339
>XP_006718010
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  QYLIQVTH 8
          +YL Q TH
Sbjct: 17 EYLTQQTH 24
>XP_006713821
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QYLIQVTHS 9
           +YL QV H+
Sbjct: 290 EYLEQVVHA 298
>NP_001005289
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  YLIQVTHS 9
          YLI V HS
Sbjct: 55 YLIVVEHS 62
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.129    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 568,400
Number of extensions: 1178
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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