Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     869
NP_653080                                                              19     869
XP_005267292                                                           19     869
XP_005267291                                                           19     869
XP_005267290                                                           19     869
XP_006713065                                                           17    3301
XP_005264953                                                           17    3301
XP_006713064                                                           17    3301
XP_006713063                                                           17    3301
XP_006713062                                                           17    3301
XP_006713061                                                           17    3301
XP_006713060                                                           17    3301
XP_006713059                                                           17    3301
XP_006713058                                                           17    3301
XP_006713057                                                           17    3301
NP_955379                                                              17    3301
NP_733751                                                              17    4312
XP_006716142                                                           17    4312
XP_005250088                                                           17    4312
XP_006716141                                                           17    4312
XP_005250085                                                           17    4312
XP_006716140                                                           17    4312
XP_005250084                                                           17    4312
XP_005250083                                                           17    4312
XP_005250082                                                           17    4312
NP_001254465                                                           16    5631
NP_001157937                                                           16    5631
NP_937824                                                              16    5631
NP_254273                                                              16    5631
NP_061122                                                              16    5631
NP_001138696                                                           16    5631
NP_001157876                                                           16    5631
XP_006726644                                                           16    5631
XP_006726639                                                           16    5631
XP_006726630                                                           16    5631
XP_006725247                                                           16    5631
XP_006725246                                                           16    5631
XP_006720873                                                           16    5631
XP_006720716                                                           16    5631
XP_006720715                                                           16    5631
XP_006720668                                                           16    5631
XP_006720667                                                           16    5631
XP_006710051                                                           16    5631
NP_001033729                                                           16    5631
NP_001265543                                                           16    7355
NP_003352                                                              16    7355
NP_001008390                                                           16    7355
NP_001271226                                                           16    7355
NP_001271227                                                           16    7355
XP_006721151                                                           16    7355
XP_006721150                                                           16    7355
XP_006721149                                                           16    7355
XP_006721148                                                           16    7355
XP_005254506                                                           16    7355
XP_005254505                                                           16    7355
XP_006720635                                                           16    7355
XP_006720634                                                           16    7355
NP_004564                                                              16    7355
NP_001242910                                                           15    9605
NP_570968                                                              15    9605
NP_001242909                                                           15    9605
NP_001242908                                                           15    9605
NP_001242907                                                           15    9605
XP_005272080                                                           15    9605
XP_005272077                                                           15    9605
XP_006711235                                                           15    9605
>NP_005091
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QVTENIESS 9
            QVTE+IESS
Sbjct: 1125 QVTESIESS 1133
>NP_653080
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QVTENIESS 9
            QVTE+IESS
Sbjct: 1027 QVTESIESS 1035
>XP_005267292
          Length = 1677

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QVTENIESS 9
            QVTE+IESS
Sbjct: 1020 QVTESIESS 1028
>XP_005267291
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QVTENIESS 9
            QVTE+IESS
Sbjct: 1027 QVTESIESS 1035
>XP_005267290
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    QVTENIESS 9
            QVTE+IESS
Sbjct: 1125 QVTESIESS 1133
>XP_006713065
          Length = 709

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>XP_005264953
          Length = 713

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>XP_006713064
          Length = 1115

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>XP_006713063
          Length = 1125

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>XP_006713062
          Length = 1158

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>XP_006713061
          Length = 1162

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>XP_006713060
          Length = 1162

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>XP_006713059
          Length = 1172

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>XP_006713058
          Length = 1172

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>XP_006713057
          Length = 1172

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>NP_955379
          Length = 712

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+ ENIES
Sbjct: 498 QIAENIES 505
>NP_733751
          Length = 4911

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVTENIE 7
           +VTENIE
Sbjct: 648 EVTENIE 654
>XP_006716142
          Length = 4927

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVTENIE 7
           +VTENIE
Sbjct: 649 EVTENIE 655
>XP_005250088
          Length = 4928

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVTENIE 7
           +VTENIE
Sbjct: 649 EVTENIE 655
>XP_006716141
          Length = 4959

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVTENIE 7
           +VTENIE
Sbjct: 649 EVTENIE 655
>XP_005250085
          Length = 4979

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVTENIE 7
           +VTENIE
Sbjct: 649 EVTENIE 655
>XP_006716140
          Length = 4982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVTENIE 7
           +VTENIE
Sbjct: 649 EVTENIE 655
>XP_005250084
          Length = 4982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVTENIE 7
           +VTENIE
Sbjct: 649 EVTENIE 655
>XP_005250083
          Length = 4982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVTENIE 7
           +VTENIE
Sbjct: 648 EVTENIE 654
>XP_005250082
          Length = 4983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QVTENIE 7
           +VTENIE
Sbjct: 649 EVTENIE 655
>NP_001254465
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 107 QLTENINS 114
>NP_001157937
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 107 QLTENINS 114
>NP_937824
          Length = 432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 107 QLTENINS 114
>NP_254273
          Length = 289

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QVTENIESS 9
           Q+T N ESS
Sbjct: 137 QITVNFESS 145
>NP_061122
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QVTENIES 8
          Q+ ENIES
Sbjct: 87 QLNENIES 94
>NP_001138696
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QVTENIES 8
          Q+ ENIES
Sbjct: 87 QLNENIES 94
>NP_001157876
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QVTENIES 8
          Q+ ENIES
Sbjct: 87 QLNENIES 94
>XP_006726644
          Length = 523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 107 QLTENINS 114
>XP_006726639
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 316 QLTENINS 323
>XP_006726630
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 107 QLTENINS 114
>XP_006725247
          Length = 550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 107 QLTENINS 114
>XP_006725246
          Length = 536

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 107 QLTENINS 114
>XP_006720873
          Length = 523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 107 QLTENINS 114
>XP_006720716
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QVTENIES 8
          Q+ ENIES
Sbjct: 87 QLNENIES 94
>XP_006720715
          Length = 689

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QVTENIES 8
          Q+ ENIES
Sbjct: 87 QLNENIES 94
>XP_006720668
          Length = 595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QVTENIES 8
          Q+ ENIES
Sbjct: 87 QLNENIES 94
>XP_006720667
          Length = 684

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QVTENIES 8
          Q+ ENIES
Sbjct: 87 QLNENIES 94
>XP_006710051
          Length = 143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q+TENI S
Sbjct: 108 QLTENINS 115
>NP_001033729
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QVTENIES 8
          Q+ ENIES
Sbjct: 87 QLNENIES 94
>NP_001265543
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QVTENIESS 9
           QV EN ESS
Sbjct: 569 QVVENGESS 577
>NP_003352
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QVTENIESS 9
           QV EN ESS
Sbjct: 536 QVVENGESS 544
>NP_001008390
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QVTENIESS 9
           QV EN ESS
Sbjct: 536 QVVENGESS 544
>NP_001271226
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QVTENIE 7
            Q+TEN+E
Sbjct: 1085 QMTENLE 1091
>NP_001271227
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QVTENIE 7
            Q+TEN+E
Sbjct: 1074 QMTENLE 1080
>XP_006721151
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QVTENIESS 9
           QV EN ESS
Sbjct: 536 QVVENGESS 544
>XP_006721150
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QVTENIESS 9
           QV EN ESS
Sbjct: 536 QVVENGESS 544
>XP_006721149
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QVTENIESS 9
           QV EN ESS
Sbjct: 536 QVVENGESS 544
>XP_006721148
          Length = 668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   QVTENIESS 9
           QV EN ESS
Sbjct: 564 QVVENGESS 572
>XP_005254506
          Length = 1123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QVTENIE 7
            Q+TEN+E
Sbjct: 1089 QMTENLE 1095
>XP_005254505
          Length = 1124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QVTENIE 7
            Q+TEN+E
Sbjct: 1089 QMTENLE 1095
>XP_006720635
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QVTENIE 7
            Q+TEN+E
Sbjct: 1089 QMTENLE 1095
>XP_006720634
          Length = 1184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QVTENIE 7
            Q+TEN+E
Sbjct: 1088 QMTENLE 1094
>NP_004564
          Length = 1185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    QVTENIE 7
            Q+TEN+E
Sbjct: 1089 QMTENLE 1095
>NP_001242910
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTENIES 8
           VTEN+E+
Sbjct: 323 VTENLET 329
>NP_570968
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTENIES 8
           VTEN+E+
Sbjct: 343 VTENLET 349
>NP_001242909
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTENIES 8
           VTEN+E+
Sbjct: 323 VTENLET 329
>NP_001242908
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTENIES 8
           VTEN+E+
Sbjct: 343 VTENLET 349
>NP_001242907
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTENIES 8
           VTEN+E+
Sbjct: 343 VTENLET 349
>XP_005272080
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q +EN+ES
Sbjct: 245 QCSENVES 252
>XP_005272077
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QVTENIES 8
           Q +EN+ES
Sbjct: 415 QCSENVES 422
>XP_006711235
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTENIES 8
           VTEN+E+
Sbjct: 323 VTENLET 329
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.280    0.101    0.218 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 376,946
Number of extensions: 399
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.6 bits)
S2: 28 (15.4 bits)

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