Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     390
XP_005266703                                                           20     390
NP_004250                                                              17    4312
NP_001129502                                                           17    4312
NP_001092285                                                           17    4312
NP_001248773                                                           17    4312
NP_055611                                                              17    4312
XP_005257879                                                           17    4312
XP_006722249                                                           17    4312
XP_005257875                                                           17    4312
XP_005269304                                                           17    4312
XP_006719779                                                           17    4312
XP_005269303                                                           17    4312
XP_006719778                                                           17    4312
XP_005269302                                                           17    4312
XP_005269301                                                           17    4312
XP_005269300                                                           17    4312
NP_775866                                                              16    7355
NP_004228                                                              16    7355
NP_066277                                                              16    7355
XP_005248445                                                           16    7355
NP_001276                                                              16    7355
NP_001269810                                                           15    9605
NP_001093587                                                           15    9605
NP_055492                                                              15    9605
NP_001193928                                                           15    9605
NP_057263                                                              15    9605
NP_001129430                                                           15    9605
NP_001129428                                                           15    9605
NP_001129427                                                           15    9605
NP_001092284                                                           15    9605
NP_001273700                                                           15    9605
NP_001075019                                                           15    9605
NP_115593                                                              15    9605
NP_003297                                                              15    9605
NP_942592                                                              15    9605
NP_009105                                                              15    9605
XP_006724836                                                           15    9605
XP_005262507                                                           15    9605
XP_006724835                                                           15    9605
XP_006724834                                                           15    9605
XP_006724833                                                           15    9605
XP_006724832                                                           15    9605
XP_006724831                                                           15    9605
XP_006724830                                                           15    9605
XP_005262504                                                           15    9605
XP_005256248                                                           15    9605
XP_005253886                                                           15    9605
XP_006719269                                                           15    9605
XP_006716762                                                           15    9605
XP_006716758                                                           15    9605
XP_006716757                                                           15    9605
XP_006716756                                                           15    9605
XP_005251165                                                           15    9605
XP_005251164                                                           15    9605
XP_005251163                                                           15    9605
XP_006716755                                                           15    9605
XP_006716754                                                           15    9605
XP_006716753                                                           15    9605
XP_005265730                                                           15    9605
XP_005265729                                                           15    9605
XP_005265728                                                           15    9605
XP_005265724                                                           15    9605
NP_001129429                                                           15    9605
NP_113678                                                              15    9605
>NP_443179
          Length = 2170

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QTVDRADLR 9
            QTVDRAD R
Sbjct: 1112 QTVDRADFR 1120
>XP_005266703
          Length = 1501

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           QTVDRAD R
Sbjct: 443 QTVDRADFR 451
>NP_004250
          Length = 991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QTVDRADLR 9
           +T D ADLR
Sbjct: 569 RTADEADLR 577
>NP_001129502
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 466 QSVDRPELR 474
>NP_001092285
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 466 QSVDRPELR 474
>NP_001248773
          Length = 383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 328 QSVDRPELR 336
>NP_055611
          Length = 383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 328 QSVDRPELR 336
>XP_005257879
          Length = 586

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QTVDRADLR 9
           +T D ADLR
Sbjct: 164 RTADEADLR 172
>XP_006722249
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QTVDRADLR 9
           +T D ADLR
Sbjct: 164 RTADEADLR 172
>XP_005257875
          Length = 1012

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QTVDRADLR 9
           +T D ADLR
Sbjct: 569 RTADEADLR 577
>XP_005269304
          Length = 383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 328 QSVDRPELR 336
>XP_006719779
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 466 QSVDRPELR 474
>XP_005269303
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 466 QSVDRPELR 474
>XP_006719778
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 466 QSVDRPELR 474
>XP_005269302
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 466 QSVDRPELR 474
>XP_005269301
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 466 QSVDRPELR 474
>XP_005269300
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QTVDRADLR 9
           Q+VDR +LR
Sbjct: 466 QSVDRPELR 474
>NP_775866
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TVDRADLR 9
           T D ADLR
Sbjct: 713 TADAADLR 720
>NP_004228
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VDRADLR 9
           VDRAD++
Sbjct: 310 VDRADIK 316
>NP_066277
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TVDRADL 8
          T+DRAD+
Sbjct: 42 TLDRADM 48
>XP_005248445
          Length = 417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VDRADLR 9
           VDRAD++
Sbjct: 295 VDRADIK 301
>NP_001276
          Length = 914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QTVDRADLR 9
           Q VD+ DL+
Sbjct: 845 QAVDKVDLK 853
>NP_001269810
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 251 IDRPDLR 257
>NP_001093587
          Length = 1349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 443 IDRPDLR 449
>NP_055492
          Length = 1163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 251 IDRPDLR 257
>NP_001193928
          Length = 2069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    QTVDRADL 8
            + +DRADL
Sbjct: 1221 EALDRADL 1228
>NP_057263
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTVDRADL 8
           Q +DR+DL
Sbjct: 385 QHIDRSDL 392
>NP_001129430
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTVDRADL 8
           Q +DR+DL
Sbjct: 212 QHIDRSDL 219
>NP_001129428
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTVDRADL 8
           Q +DR+DL
Sbjct: 385 QHIDRSDL 392
>NP_001129427
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTVDRADL 8
           Q +DR+DL
Sbjct: 385 QHIDRSDL 392
>NP_001092284
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VDRADL 8
           +DRADL
Sbjct: 215 IDRADL 220
>NP_001273700
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TVDRADLR 9
          T D ADLR
Sbjct: 45 TADGADLR 52
>NP_001075019
          Length = 1593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>NP_115593
          Length = 2603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TVDRADLR 9
           T D ADLR
Sbjct: 158 TADGADLR 165
>NP_003297
          Length = 982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTVDRADL 8
           Q +DR+DL
Sbjct: 385 QHIDRSDL 392
>NP_942592
          Length = 2352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TVDRADLR 9
           T D ADLR
Sbjct: 158 TADGADLR 165
>NP_009105
          Length = 2027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    QTVDRADL 8
            + +DRADL
Sbjct: 1179 EALDRADL 1186
>XP_006724836
          Length = 1582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>XP_005262507
          Length = 1594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>XP_006724835
          Length = 1615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>XP_006724834
          Length = 1615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>XP_006724833
          Length = 1620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>XP_006724832
          Length = 1640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>XP_006724831
          Length = 1640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>XP_006724830
          Length = 1642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>XP_005262504
          Length = 1642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QTVDRA 6
           QT+DRA
Sbjct: 544 QTIDRA 549
>XP_005256248
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TVDRADLR 9
           T DR D+R
Sbjct: 282 TTDRLDIR 289
>XP_005253886
          Length = 1545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTVDRADL 8
           + +DRADL
Sbjct: 713 EALDRADL 720
>XP_006719269
          Length = 2054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    QTVDRADL 8
            + +DRADL
Sbjct: 1221 EALDRADL 1228
>XP_006716762
          Length = 1571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_006716758
          Length = 1269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_006716757
          Length = 1356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 251 IDRPDLR 257
>XP_006716756
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_005251165
          Length = 1532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 483 IDRPDLR 489
>XP_005251164
          Length = 1552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 443 IDRPDLR 449
>XP_005251163
          Length = 1574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 443 IDRPDLR 449
>XP_006716755
          Length = 1634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_006716754
          Length = 1655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_006716753
          Length = 1656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VDRADLR 9
           +DR DLR
Sbjct: 487 IDRPDLR 493
>XP_005265730
          Length = 1480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TVDRADLR 9
           T D ADLR
Sbjct: 158 TADGADLR 165
>XP_005265729
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TVDRADLR 9
           T D ADLR
Sbjct: 158 TADGADLR 165
>XP_005265728
          Length = 2351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TVDRADLR 9
           T D ADLR
Sbjct: 158 TADGADLR 165
>XP_005265724
          Length = 2602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TVDRADLR 9
           T D ADLR
Sbjct: 158 TADGADLR 165
>NP_001129429
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QTVDRADL 8
           Q +DR+DL
Sbjct: 385 QHIDRSDL 392
>NP_113678
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TVDRADLR 9
           T DR D+R
Sbjct: 326 TTDRLDIR 333
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.133    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 419,623
Number of extensions: 547
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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