Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     390
NP_001035957                                                           20     390
XP_006721991                                                           20     390
XP_006721990                                                           20     390
XP_006721989                                                           20     390
XP_005258041                                                           20     390
XP_006721988                                                           20     390
XP_006721987                                                           20     390
XP_006721986                                                           20     390
XP_005258040                                                           20     390
XP_006721985                                                           20     390
NP_612350                                                              18    1935
NP_001180382                                                           18    1935
NP_001180460                                                           18    1935
XP_006719743                                                           18    1935
XP_006719742                                                           18    1935
XP_006719741                                                           18    1935
XP_005254043                                                           18    1935
XP_005254042                                                           18    1935
NP_001258593                                                           17    2528
NP_001138476                                                           17    2528
NP_001001413                                                           17    2528
XP_006726626                                                           17    2528
XP_006726624                                                           17    2528
XP_006726623                                                           17    2528
XP_006725630                                                           17    2528
XP_006725629                                                           17    2528
XP_006725599                                                           17    2528
XP_006726291                                                           17    2528
XP_006726290                                                           17    2528
XP_006725238                                                           17    2528
XP_006720863                                                           17    2528
XP_006720862                                                           17    2528
XP_006720860                                                           17    2528
XP_006720859                                                           17    2528
XP_006720858                                                           17    2528
XP_006720426                                                           17    2528
NP_001277114                                                           16    7355
NP_068375                                                              16    7355
NP_005992                                                              16    7355
NP_001229831                                                           16    7355
NP_525125                                                              16    7355
NP_001229832                                                           16    7355
NP_001180343                                                           16    7355
NP_997195                                                              16    7355
NP_003479                                                              16    7355
NP_061816                                                              16    7355
XP_006722190                                                           16    7355
XP_005257766                                                           16    7355
XP_005257764                                                           16    7355
XP_006722189                                                           16    7355
XP_005249641                                                           16    7355
NP_066939                                                              16    7355
NP_056246                                                              16    7355
>NP_000258
          Length = 2818

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 684 QTKLEVALY 692
>NP_001035957
          Length = 2839

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 684 QTKLEVALY 692
>XP_006721991
          Length = 1632

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 694 QTKLEVALY 702
>XP_006721990
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 694 QTKLEVALY 702
>XP_006721989
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 694 QTKLEVALY 702
>XP_005258041
          Length = 2836

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 684 QTKLEVALY 692
>XP_006721988
          Length = 2846

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 694 QTKLEVALY 702
>XP_006721987
          Length = 2849

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 694 QTKLEVALY 702
>XP_006721986
          Length = 2854

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 681 QTKLEVALY 689
>XP_005258040
          Length = 2857

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 684 QTKLEVALY 692
>XP_006721985
          Length = 2867

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           QTKLE+ALY
Sbjct: 694 QTKLEVALY 702
>NP_612350
          Length = 245

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKLEMALY 9
           TKL MALY
Sbjct: 167 TKLHMALY 174
>NP_001180382
          Length = 302

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKLEMALY 9
           TKL MALY
Sbjct: 224 TKLHMALY 231
>NP_001180460
          Length = 337

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKLEMALY 9
           TKL MALY
Sbjct: 259 TKLHMALY 266
>XP_006719743
          Length = 245

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKLEMALY 9
           TKL MALY
Sbjct: 167 TKLHMALY 174
>XP_006719742
          Length = 336

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKLEMALY 9
           TKL MALY
Sbjct: 258 TKLHMALY 265
>XP_006719741
          Length = 364

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKLEMALY 9
           TKL MALY
Sbjct: 286 TKLHMALY 293
>XP_005254043
          Length = 371

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKLEMALY 9
           TKL MALY
Sbjct: 293 TKLHMALY 300
>XP_005254042
          Length = 394

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKLEMALY 9
           TKL MALY
Sbjct: 316 TKLHMALY 323
>NP_001258593
          Length = 670

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 127 KTELQMALY 135
>NP_001138476
          Length = 724

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 127 KTELQMALY 135
>NP_001001413
          Length = 668

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 139 KTELQMALY 147
>XP_006726626
          Length = 678

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 115 KTELQMALY 123
>XP_006726624
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 121 KTELQMALY 129
>XP_006726623
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 121 KTELQMALY 129
>XP_006725630
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 121 KTELQMALY 129
>XP_006725629
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 121 KTELQMALY 129
>XP_006725599
          Length = 466

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 139 KTELQMALY 147
>XP_006726291
          Length = 624

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 121 KTELQMALY 129
>XP_006726290
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 121 KTELQMALY 129
>XP_006725238
          Length = 466

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 139 KTELQMALY 147
>XP_006720863
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 121 KTELQMALY 129
>XP_006720862
          Length = 570

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 127 KTELQMALY 135
>XP_006720860
          Length = 434

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 115 KTELQMALY 123
>XP_006720859
          Length = 603

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 115 KTELQMALY 123
>XP_006720858
          Length = 651

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 115 KTELQMALY 123
>XP_006720426
          Length = 466

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QTKLEMALY 9
           +T+L+MALY
Sbjct: 139 KTELQMALY 147
>NP_001277114
          Length = 931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QTKLEM 6
           QTKLEM
Sbjct: 348 QTKLEM 353
>NP_068375
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QTKLEM 6
           QTKLEM
Sbjct: 358 QTKLEM 363
>NP_005992
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTKLEMALY 9
           ++KLE A+Y
Sbjct: 164 KSKLEFAIY 172
>NP_001229831
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TKLEMAL 8
           TKLE+AL
Sbjct: 129 TKLELAL 135
>NP_525125
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTKLEMALY 9
           ++KLE A+Y
Sbjct: 164 KSKLEFAIY 172
>NP_001229832
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TKLEMAL 8
           TKLE+AL
Sbjct: 129 TKLELAL 135
>NP_001180343
          Length = 383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTKLEMALY 9
           ++KLE A+Y
Sbjct: 98  KSKLEFAIY 106
>NP_997195
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTKLEMALY 9
           ++KLE A+Y
Sbjct: 164 KSKLEFAIY 172
>NP_003479
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TKLEMAL 8
           TKLE+AL
Sbjct: 129 TKLELAL 135
>NP_061816
          Length = 449

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QTKLEMALY 9
           ++KLE A+Y
Sbjct: 164 KSKLEFAIY 172
>XP_006722190
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TKLEMAL 8
           TKLE+AL
Sbjct: 129 TKLELAL 135
>XP_005257766
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TKLEMAL 8
           TKLE+AL
Sbjct: 129 TKLELAL 135
>XP_005257764
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TKLEMAL 8
           TKLE+AL
Sbjct: 129 TKLELAL 135
>XP_006722189
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TKLEMAL 8
           TKLE+AL
Sbjct: 129 TKLELAL 135
>XP_005249641
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTKLEMA 7
           QT+LEMA
Sbjct: 577 QTELEMA 583
>NP_066939
          Length = 1119

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QTKLEMA 7
           QT+LEMA
Sbjct: 577 QTELEMA 583
>NP_056246
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QTKLEMAL 8
           Q KL+MAL
Sbjct: 140 QVKLQMAL 147
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.126    0.318 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 348,637
Number of extensions: 432
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package