Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_001171886                                                           18    1482
NP_115513                                                              18    1482
NP_001171887                                                           18    1482
XP_006713407                                                           18    1482
XP_006713406                                                           18    1482
XP_006713405                                                           18    1482
XP_006713404                                                           18    1482
NP_004466                                                              16    5631
NP_002009                                                              16    5631
NP_079032                                                              16    5631
NP_001243193                                                           16    5631
NP_001243194                                                           16    5631
XP_006721915                                                           16    5631
XP_005258010                                                           16    5631
XP_005258009                                                           16    5631
XP_005258007                                                           16    5631
XP_005256615                                                           16    5631
XP_005256613                                                           16    5631
XP_005256612                                                           16    5631
XP_005270210                                                           16    5631
XP_006718033                                                           16    5631
NP_055418                                                              16    5631
NP_001129111                                                           16    7355
NP_001288                                                              16    7355
NP_001273059                                                           16    7355
NP_055898                                                              16    7355
NP_057591                                                              16    7355
NP_671725                                                              16    7355
NP_757379                                                              16    7355
NP_055833                                                              16    7355
NP_001186871                                                           16    7355
NP_001180438                                                           16    7355
NP_060205                                                              16    7355
NP_932157                                                              16    7355
XP_005257515                                                           16    7355
XP_005257513                                                           16    7355
XP_006721197                                                           16    7355
XP_006715463                                                           16    7355
XP_006715462                                                           16    7355
XP_006715461                                                           16    7355
XP_006715460                                                           16    7355
XP_006715459                                                           16    7355
XP_006715458                                                           16    7355
XP_006715457                                                           16    7355
XP_006715456                                                           16    7355
XP_005248379                                                           16    7355
XP_005248378                                                           16    7355
XP_005264473                                                           16    7355
XP_006710466                                                           16    7355
XP_005270625                                                           16    7355
XP_006710418                                                           16    7355
NP_060610                                                              16    7355
NP_004076                                                              15    9605
NP_001139423                                                           15    9605
NP_003679                                                              15    9605
NP_001119526                                                           15    9605
NP_001119527                                                           15    9605
NP_003553                                                              15    9605
NP_001158889                                                           15    9605
XP_005262149                                                           15    9605
XP_006724629                                                           15    9605
XP_006724628                                                           15    9605
XP_005272743                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QSVHALTEI 9
            QSV ALTEI
Sbjct: 3130 QSVQALTEI 3138
>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QSVHALTEI 9
            QSV ALTEI
Sbjct: 3130 QSVQALTEI 3138
>NP_001171886
          Length = 782

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QSVHALTEI 9
          QS+H LTE+
Sbjct: 18 QSIHLLTEL 26
>NP_115513
          Length = 904

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           QS+H LTE+
Sbjct: 140 QSIHLLTEL 148
>NP_001171887
          Length = 782

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  QSVHALTEI 9
          QS+H LTE+
Sbjct: 18 QSIHLLTEL 26
>XP_006713407
          Length = 648

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           QS+H LTE+
Sbjct: 140 QSIHLLTEL 148
>XP_006713406
          Length = 669

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           QS+H LTE+
Sbjct: 140 QSIHLLTEL 148
>XP_006713405
          Length = 947

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           QS+H LTE+
Sbjct: 140 QSIHLLTEL 148
>XP_006713404
          Length = 947

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           QS+H LTE+
Sbjct: 140 QSIHLLTEL 148
>NP_004466
          Length = 428

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVHALTEI 9
           SVHALT +
Sbjct: 405 SVHALTGV 412
>NP_002009
          Length = 1269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           +++H LTEI
Sbjct: 357 EAIHFLTEI 365
>NP_079032
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QSVHALTE 8
           QS+H+LT+
Sbjct: 250 QSLHSLTQ 257
>NP_001243193
          Length = 1258

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           +++H LTEI
Sbjct: 346 EAIHFLTEI 354
>NP_001243194
          Length = 1214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           +++H LTEI
Sbjct: 303 EAIHFLTEI 311
>XP_006721915
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QSVHALTE 8
           Q +H LTE
Sbjct: 110 QKIHGLTE 117
>XP_005258010
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVHALTEI 9
           SVHALT +
Sbjct: 328 SVHALTGV 335
>XP_005258009
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVHALTEI 9
           SVHALT +
Sbjct: 356 SVHALTGV 363
>XP_005258007
          Length = 428

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SVHALTEI 9
           SVHALT +
Sbjct: 405 SVHALTGV 412
>XP_005256615
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           +++H LTEI
Sbjct: 357 EAIHFLTEI 365
>XP_005256613
          Length = 1295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           +++H LTEI
Sbjct: 357 EAIHFLTEI 365
>XP_005256612
          Length = 1296

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QSVHALTEI 9
           +++H LTEI
Sbjct: 357 EAIHFLTEI 365
>XP_005270210
          Length = 888

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QSVHALTE 8
           QS+H+LT+
Sbjct: 189 QSLHSLTQ 196
>XP_006718033
          Length = 888

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QSVHALTE 8
           QS+H+LT+
Sbjct: 189 QSLHSLTQ 196
>NP_055418
          Length = 465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   QSVHALTE 8
           Q +H LTE
Sbjct: 110 QKIHGLTE 117
>NP_001129111
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           Q VH++TE
Sbjct: 116 QPVHSITE 123
>NP_001288
          Length = 1251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           Q VH++TE
Sbjct: 116 QPVHSITE 123
>NP_001273059
          Length = 1245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           Q VH++TE
Sbjct: 116 QPVHSITE 123
>NP_055898
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QSVHALTE 8
            QS+ ALTE
Sbjct: 1155 QSISALTE 1162
>NP_057591
          Length = 1490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QSVHALTE 8
            QS+ ALTE
Sbjct: 1155 QSISALTE 1162
>NP_671725
          Length = 382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SVHALT 7
          SVHALT
Sbjct: 40 SVHALT 45
>NP_757379
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SVHALT 7
          SVHALT
Sbjct: 40 SVHALT 45
>NP_055833
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2034 SVHALT 2039
>NP_001186871
          Length = 2476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2025 SVHALT 2030
>NP_001180438
          Length = 793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VHALTEI 9
           VH LTE+
Sbjct: 310 VHTLTEV 316
>NP_060205
          Length = 843

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VHALTEI 9
           VH LTE+
Sbjct: 360 VHTLTEV 366
>NP_932157
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VHALTEI 9
           VHALT++
Sbjct: 525 VHALTDL 531
>XP_005257515
          Length = 1256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QSVHALTE 8
            QS+ ALTE
Sbjct: 1155 QSISALTE 1162
>XP_005257513
          Length = 1489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    QSVHALTE 8
            QS+ ALTE
Sbjct: 1154 QSISALTE 1161
>XP_006721197
          Length = 1251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           Q VH++TE
Sbjct: 116 QPVHSITE 123
>XP_006715463
          Length = 2434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2034 SVHALT 2039
>XP_006715462
          Length = 2452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2001 SVHALT 2006
>XP_006715461
          Length = 2456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2025 SVHALT 2030
>XP_006715460
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2034 SVHALT 2039
>XP_006715459
          Length = 2475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2024 SVHALT 2029
>XP_006715458
          Length = 2476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2025 SVHALT 2030
>XP_006715457
          Length = 2485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2034 SVHALT 2039
>XP_006715456
          Length = 2485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SVHALT 7
            SVHALT
Sbjct: 2034 SVHALT 2039
>XP_005248379
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VHALTEI 9
          +HALTE+
Sbjct: 47 LHALTEL 53
>XP_005248378
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VHALTEI 9
           +HALTE+
Sbjct: 97  LHALTEL 103
>XP_005264473
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VHALTEI 9
           VH LTE+
Sbjct: 360 VHTLTEV 366
>XP_006710466
          Length = 357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VHALTEI 9
          VHALT++
Sbjct: 24 VHALTDL 30
>XP_005270625
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VHALTEI 9
          VHALT++
Sbjct: 33 VHALTDL 39
>XP_006710418
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  SVHALT 7
          SVHALT
Sbjct: 40 SVHALT 45
>NP_060610
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VHALTEI 9
           +HALTE+
Sbjct: 97  LHALTEL 103
>NP_004076
          Length = 97

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QSVHALTEI 9
          Q VH +TE+
Sbjct: 34 QLVHQMTEL 42
>NP_001139423
          Length = 48

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QSVHALTEI 9
          Q VH +TE+
Sbjct: 34 QLVHQMTEL 42
>NP_003679
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           + +HALT+
Sbjct: 355 EEIHALTD 362
>NP_001119526
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           + +HALT+
Sbjct: 355 EEIHALTD 362
>NP_001119527
          Length = 897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           + +HALT+
Sbjct: 349 EEIHALTD 356
>NP_003553
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  SVHALTEI 9
          S HALT I
Sbjct: 64 SFHALTSI 71
>NP_001158889
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  SVHALTEI 9
          S HALT I
Sbjct: 53 SFHALTSI 60
>XP_005262149
          Length = 112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QSVHALTEI 9
          Q VH +TE+
Sbjct: 34 QLVHQMTEL 42
>XP_006724629
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           + +HALT+
Sbjct: 349 EEIHALTD 356
>XP_006724628
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           + +HALT+
Sbjct: 349 EEIHALTD 356
>XP_005272743
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   QSVHALTE 8
           + +HALT+
Sbjct: 349 EEIHALTD 356
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.120    0.302 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 498,073
Number of extensions: 717
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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