Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              18    1935
NP_444254                                                              18    1935
NP_444253                                                              18    1935
NP_444255                                                              18    1935
XP_005247551                                                           18    1935
XP_005247550                                                           18    1935
XP_006713712                                                           18    1935
XP_005247549                                                           18    1935
NP_001182000                                                           16    5631
NP_036396                                                              16    5631
NP_001182001                                                           16    5631
XP_005261571                                                           16    5631
XP_005261570                                                           16    5631
XP_005261569                                                           16    5631
XP_006724290                                                           16    5631
XP_005261568                                                           16    5631
XP_005261567                                                           16    5631
XP_005261566                                                           16    5631
NP_001167571                                                           16    7355
NP_127503                                                              16    7355
NP_127501                                                              16    7355
NP_065151                                                              16    7355
XP_006713334                                                           16    7355
XP_006713333                                                           16    7355
XP_005265389                                                           16    7355
XP_005265388                                                           16    7355
XP_006713332                                                           16    7355
XP_006713331                                                           16    7355
XP_006713330                                                           16    7355
XP_006713329                                                           16    7355
XP_005265387                                                           16    7355

>NP_444256
          Length = 1794

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SARVSVSE 9
           SARVSVSE
Sbjct: 204 SARVSVSE 211



>NP_444254
          Length = 1845

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SARVSVSE 9
           SARVSVSE
Sbjct: 204 SARVSVSE 211



>NP_444253
          Length = 1914

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SARVSVSE 9
           SARVSVSE
Sbjct: 204 SARVSVSE 211



>NP_444255
          Length = 1863

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SARVSVSE 9
           SARVSVSE
Sbjct: 204 SARVSVSE 211



>XP_005247551
          Length = 1855

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SARVSVSE 9
           SARVSVSE
Sbjct: 214 SARVSVSE 221



>XP_005247550
          Length = 1856

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SARVSVSE 9
           SARVSVSE
Sbjct: 214 SARVSVSE 221



>XP_006713712
          Length = 1923

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SARVSVSE 9
           SARVSVSE
Sbjct: 214 SARVSVSE 221



>XP_005247549
          Length = 1924

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SARVSVSE 9
           SARVSVSE
Sbjct: 214 SARVSVSE 221



>NP_001182000
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 280 SARVSVGE 287



>NP_036396
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 280 SARVSVGE 287



>NP_001182001
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 214 SARVSVGE 221



>XP_005261571
          Length = 348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 214 SARVSVGE 221



>XP_005261570
          Length = 348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 214 SARVSVGE 221



>XP_005261569
          Length = 365

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 313 SARVSVGE 320



>XP_006724290
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 280 SARVSVGE 287



>XP_005261568
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 280 SARVSVGE 287



>XP_005261567
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 313 SARVSVGE 320



>XP_005261566
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SARVSVSE 9
           SARVSV E
Sbjct: 313 SARVSVGE 320



>NP_001167571
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 48 SARITISE 55



>NP_127503
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 48 SARITISE 55



>NP_127501
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 48 SARITISE 55



>NP_065151
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 48 SARITISE 55



>XP_006713334
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 71 SARITISE 78



>XP_006713333
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 48 SARITISE 55



>XP_005265389
          Length = 383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 71 SARITISE 78



>XP_005265388
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 48 SARITISE 55



>XP_006713332
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 48 SARITISE 55



>XP_006713331
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 48 SARITISE 55



>XP_006713330
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 14 SARITISE 21



>XP_006713329
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 14 SARITISE 21



>XP_005265387
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SARVSVSE 9
          SAR+++SE
Sbjct: 71 SARITISE 78



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.290   0.0985    0.203 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 151,589
Number of extensions: 143
Number of successful extensions: 31
Number of sequences better than 10000.0: 31
Number of HSP's gapped: 31
Number of HSP's successfully gapped: 31
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)