Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              19     869
NP_000172                                                              16    5631
NP_689585                                                              16    5631
NP_660274                                                              16    5631
NP_001271197                                                           16    5631
NP_001271198                                                           16    5631
NP_001271196                                                           16    5631
NP_001271195                                                           16    5631
NP_997245                                                              16    5631
XP_005250354                                                           16    5631
XP_005263984                                                           16    5631
XP_005263983                                                           16    5631
XP_005263982                                                           16    5631
XP_005263981                                                           16    5631
XP_005263980                                                           16    5631
NP_001275664                                                           16    7355
NP_001275665                                                           16    7355
NP_008972                                                              16    7355
NP_001104582                                                           16    7355
NP_005330                                                              16    7355
XP_005269517                                                           16    7355
NP_073600                                                              15    9605
NP_001128567                                                           15    9605
NP_001071160                                                           15    9605
NP_001071159                                                           15    9605
NP_079016                                                              15    9605
NP_001071158                                                           15    9605
NP_005794                                                              15    9605
NP_001275500                                                           15    9605
NP_065801                                                              15    9605
NP_057540                                                              15    9605
NP_001275499                                                           15    9605
NP_001275497                                                           15    9605
NP_001275496                                                           15    9605
NP_001275495                                                           15    9605
NP_001275494                                                           15    9605
NP_001275493                                                           15    9605
NP_001273024                                                           15    9605
NP_065695                                                              15    9605
NP_001164225                                                           15    9605
NP_001273023                                                           15    9605
NP_001275498                                                           15    9605
XP_006726135                                                           15    9605
XP_005275560                                                           15    9605
XP_005275559                                                           15    9605
XP_006726034                                                           15    9605
XP_005275393                                                           15    9605
XP_005275392                                                           15    9605
XP_006725735                                                           15    9605
XP_005274967                                                           15    9605
XP_005274966                                                           15    9605
XP_006725528                                                           15    9605
XP_005272817                                                           15    9605
XP_005272816                                                           15    9605
XP_006718976                                                           15    9605
XP_005277781                                                           15    9605
XP_005277780                                                           15    9605
XP_006715010                                                           15    9605
XP_005248838                                                           15    9605
XP_005248837                                                           15    9605
XP_006710440                                                           15    9605
>NP_000312
          Length = 928

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QRYKLEVRL 9
           QRYKL VRL
Sbjct: 444 QRYKLGVRL 452
>NP_000172
          Length = 651

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YKLEVRL 9
           +KLEVRL
Sbjct: 256 FKLEVRL 262
>NP_689585
          Length = 1437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RYKLEVR 8
            RY++EVR
Sbjct: 1380 RYRMEVR 1386
>NP_660274
          Length = 163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QRYKLEVR 8
          QRY+ EVR
Sbjct: 90 QRYRNEVR 97
>NP_001271197
          Length = 118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QRYKLEVR 8
          QRY+ EVR
Sbjct: 66 QRYRNEVR 73
>NP_001271198
          Length = 139

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QRYKLEVR 8
          QRY+ EVR
Sbjct: 66 QRYRNEVR 73
>NP_001271196
          Length = 115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QRYKLEVR 8
          QRY+ EVR
Sbjct: 42 QRYRNEVR 49
>NP_001271195
          Length = 142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QRYKLEVR 8
          QRY+ EVR
Sbjct: 90 QRYRNEVR 97
>NP_997245
          Length = 962

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QRYKLEVRL 9
           +RY  EVRL
Sbjct: 707 KRYSAEVRL 715
>XP_005250354
          Length = 600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YKLEVRL 9
           +KLEVRL
Sbjct: 256 FKLEVRL 262
>XP_005263984
          Length = 963

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QRYKLEVRL 9
           +RY  EVRL
Sbjct: 707 KRYSAEVRL 715
>XP_005263983
          Length = 963

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QRYKLEVRL 9
           +RY  EVRL
Sbjct: 707 KRYSAEVRL 715
>XP_005263982
          Length = 977

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QRYKLEVRL 9
           +RY  EVRL
Sbjct: 721 KRYSAEVRL 729
>XP_005263981
          Length = 990

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QRYKLEVRL 9
           +RY  EVRL
Sbjct: 735 KRYSAEVRL 743
>XP_005263980
          Length = 991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QRYKLEVRL 9
           +RY  EVRL
Sbjct: 735 KRYSAEVRL 743
>NP_001275664
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YKLEVRL 9
           +KLEVRL
Sbjct: 172 HKLEVRL 178
>NP_001275665
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YKLEVRL 9
           +KLEVRL
Sbjct: 261 HKLEVRL 267
>NP_008972
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YKLEVRL 9
           +KLEVRL
Sbjct: 268 HKLEVRL 274
>NP_001104582
          Length = 157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  RYKLEVRL 9
          RY+LE+++
Sbjct: 55 RYQLEIKI 62
>NP_005330
          Length = 200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  RYKLEVRL 9
          RY+LE+++
Sbjct: 55 RYQLEIKI 62
>XP_005269517
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YKLEVRL 9
           +KLEVRL
Sbjct: 285 HKLEVRL 291
>NP_073600
          Length = 1204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QRYKLEVR 8
           Q Y+LEV+
Sbjct: 263 QEYELEVK 270
>NP_001128567
          Length = 1204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QRYKLEVR 8
           Q Y+LEV+
Sbjct: 263 QEYELEVK 270
>NP_001071160
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           QRY+LE
Sbjct: 228 QRYRLE 233
>NP_001071159
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           QRY+LE
Sbjct: 235 QRYRLE 240
>NP_079016
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           QRY+LE
Sbjct: 406 QRYRLE 411
>NP_001071158
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           QRY+LE
Sbjct: 399 QRYRLE 404
>NP_005794
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 290 ERYKLE 295
>NP_001275500
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 187 QRWKLQVQ 194
>NP_065801
          Length = 1204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QRYKLE 6
          QRY+LE
Sbjct: 27 QRYRLE 32
>NP_057540
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 162 QRWKLQVQ 169
>NP_001275499
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 165 QRWKLQVQ 172
>NP_001275497
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 162 QRWKLQVQ 169
>NP_001275496
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 162 QRWKLQVQ 169
>NP_001275495
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 162 QRWKLQVQ 169
>NP_001275494
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 162 QRWKLQVQ 169
>NP_001275493
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 162 QRWKLQVQ 169
>NP_001273024
          Length = 124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 103 QRWKLQVQ 110
>NP_065695
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 177 QRWKLQVQ 184
>NP_001164225
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   YKLEVRL 9
           Y+LE+R+
Sbjct: 128 YRLEIRI 134
>NP_001273023
          Length = 124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 103 QRWKLQVQ 110
>NP_001275498
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRYKLEVR 8
           QR+KL+V+
Sbjct: 162 QRWKLQVQ 169
>XP_006726135
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 237 ERYKLE 242
>XP_005275560
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 242 ERYKLE 247
>XP_005275559
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 290 ERYKLE 295
>XP_006726034
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 237 ERYKLE 242
>XP_005275393
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 242 ERYKLE 247
>XP_005275392
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 290 ERYKLE 295
>XP_006725735
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 237 ERYKLE 242
>XP_005274967
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 242 ERYKLE 247
>XP_005274966
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 290 ERYKLE 295
>XP_006725528
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 237 ERYKLE 242
>XP_005272817
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 242 ERYKLE 247
>XP_005272816
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 290 ERYKLE 295
>XP_006718976
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           QRY+LE
Sbjct: 406 QRYRLE 411
>XP_005277781
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           QRY+LE
Sbjct: 399 QRYRLE 404
>XP_005277780
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           QRY+LE
Sbjct: 406 QRYRLE 411
>XP_006715010
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 237 ERYKLE 242
>XP_005248838
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 242 ERYKLE 247
>XP_005248837
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRYKLE 6
           +RYKLE
Sbjct: 290 ERYKLE 295
>XP_006710440
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   YKLEVRL 9
           Y+LE+R+
Sbjct: 123 YRLEIRI 129
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.145    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 473,887
Number of extensions: 625
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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