Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1135
XP_006716142                                                           18    1135
XP_005250088                                                           18    1135
XP_006716141                                                           18    1135
XP_005250085                                                           18    1135
XP_006716140                                                           18    1135
XP_005250084                                                           18    1135
XP_005250083                                                           18    1135
XP_005250082                                                           18    1135
NP_002068                                                              17    4312
XP_006717126                                                           17    4312
XP_005251986                                                           17    4312
XP_006717125                                                           17    4312
NP_055625                                                              16    7355
NP_065875                                                              16    7355
XP_005252604                                                           16    7355
XP_005252603                                                           16    7355
XP_005252601                                                           16    7355
XP_006717551                                                           16    7355
XP_005252600                                                           16    7355
XP_005252599                                                           16    7355
XP_006717550                                                           16    7355
XP_006711734                                                           16    7355
XP_006711733                                                           16    7355
XP_006711732                                                           16    7355
XP_006711731                                                           16    7355
XP_006711730                                                           16    7355
XP_006711729                                                           16    7355
XP_005245695                                                           16    7355
NP_001229658                                                           15    9605
NP_055888                                                              15    9605
NP_065829                                                              15    9605
NP_689475                                                              15    9605
XP_006723175                                                           15    9605
XP_005258729                                                           15    9605
XP_005258728                                                           15    9605
XP_006722996                                                           15    9605
XP_005260201                                                           15    9605
XP_005260199                                                           15    9605
XP_006714307                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QRSVSEES 8
           QRSVSEES
Sbjct: 109 QRSVSEES 116
>XP_006716142
          Length = 4927

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QRSVSEES 8
           QRSVSEES
Sbjct: 110 QRSVSEES 117
>XP_005250088
          Length = 4928

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QRSVSEES 8
           QRSVSEES
Sbjct: 110 QRSVSEES 117
>XP_006716141
          Length = 4959

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QRSVSEES 8
           QRSVSEES
Sbjct: 110 QRSVSEES 117
>XP_005250085
          Length = 4979

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QRSVSEES 8
           QRSVSEES
Sbjct: 110 QRSVSEES 117
>XP_006716140
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QRSVSEES 8
           QRSVSEES
Sbjct: 110 QRSVSEES 117
>XP_005250084
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QRSVSEES 8
           QRSVSEES
Sbjct: 110 QRSVSEES 117
>XP_005250083
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QRSVSEES 8
           QRSVSEES
Sbjct: 109 QRSVSEES 116
>XP_005250082
          Length = 4983

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   QRSVSEES 8
           QRSVSEES
Sbjct: 110 QRSVSEES 117
>NP_002068
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  RSVSEESV 9
          RSVS+ESV
Sbjct: 27 RSVSKESV 34
>XP_006717126
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  RSVSEESV 9
          RSVS+ESV
Sbjct: 27 RSVSKESV 34
>XP_005251986
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  RSVSEESV 9
          RSVS+ESV
Sbjct: 27 RSVSKESV 34
>XP_006717125
          Length = 767

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  RSVSEESV 9
          RSVS+ESV
Sbjct: 27 RSVSKESV 34
>NP_055625
          Length = 3117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QRSVSEESV 9
            +RSVSE S+
Sbjct: 2177 ERSVSERSL 2185
>NP_065875
          Length = 1958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QRSVSEE 7
           QRSVS+E
Sbjct: 455 QRSVSQE 461
>XP_005252604
          Length = 1386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QRSVSEE 7
           QRSVS+E
Sbjct: 455 QRSVSQE 461
>XP_005252603
          Length = 1457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QRSVSEE 7
           QRSVS+E
Sbjct: 455 QRSVSQE 461
>XP_005252601
          Length = 1948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QRSVSEE 7
           QRSVS+E
Sbjct: 445 QRSVSQE 451
>XP_006717551
          Length = 1958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QRSVSEE 7
           QRSVS+E
Sbjct: 455 QRSVSQE 461
>XP_005252600
          Length = 1958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QRSVSEE 7
           QRSVS+E
Sbjct: 455 QRSVSQE 461
>XP_005252599
          Length = 1958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QRSVSEE 7
           QRSVS+E
Sbjct: 455 QRSVSQE 461
>XP_006717550
          Length = 1958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QRSVSEE 7
           QRSVS+E
Sbjct: 455 QRSVSQE 461
>XP_006711734
          Length = 3136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QRSVSEESV 9
            +RSVSE S+
Sbjct: 2196 ERSVSERSL 2204
>XP_006711733
          Length = 3137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QRSVSEESV 9
            +RSVSE S+
Sbjct: 2197 ERSVSERSL 2205
>XP_006711732
          Length = 3154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QRSVSEESV 9
            +RSVSE S+
Sbjct: 2214 ERSVSERSL 2222
>XP_006711731
          Length = 3157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QRSVSEESV 9
            +RSVSE S+
Sbjct: 2217 ERSVSERSL 2225
>XP_006711730
          Length = 3157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QRSVSEESV 9
            +RSVSE S+
Sbjct: 2217 ERSVSERSL 2225
>XP_006711729
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QRSVSEESV 9
            +RSVSE S+
Sbjct: 2218 ERSVSERSL 2226
>XP_005245695
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    QRSVSEESV 9
            +RSVSE S+
Sbjct: 2218 ERSVSERSL 2226
>NP_001229658
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QRSVSEES 8
           QRS  EES
Sbjct: 452 QRSTGEES 459
>NP_055888
          Length = 1781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QRSVSEESV 9
            QR++S+ES+
Sbjct: 1540 QRTLSDESL 1548
>NP_065829
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSVSEES 8
           RSVSE+S
Sbjct: 288 RSVSEDS 294
>NP_689475
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RSVSEESV 9
          RSV+EE V
Sbjct: 79 RSVTEEKV 86
>XP_006723175
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QRSVSEESV 9
           QR++S+ES+
Sbjct: 853 QRTLSDESL 861
>XP_005258729
          Length = 1780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QRSVSEESV 9
            QR++S+ES+
Sbjct: 1539 QRTLSDESL 1547
>XP_005258728
          Length = 1781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    QRSVSEESV 9
            QR++S+ES+
Sbjct: 1540 QRTLSDESL 1548
>XP_006722996
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RSVSEESV 9
          RSV+EE V
Sbjct: 84 RSVTEEKV 91
>XP_005260201
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RSVSEESV 9
          RSV+EE V
Sbjct: 84 RSVTEEKV 91
>XP_005260199
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RSVSEESV 9
          RSV+EE V
Sbjct: 84 RSVTEEKV 91
>XP_006714307
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   QRSVSEES 8
           QRS  EES
Sbjct: 234 QRSTGEES 241
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.282   0.0992    0.204 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 410,299
Number of extensions: 513
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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