Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              19     665
NP_001158184                                                           17    3301
NP_000472                                                              17    3301
NP_065988                                                              17    3301
NP_001158182                                                           17    3301
NP_001158183                                                           17    3301
XP_005267986                                                           17    3301
NP_001128662                                                           17    4312
NP_056057                                                              17    4312
NP_001035207                                                           17    4312
NP_036467                                                              17    4312
XP_005272534                                                           17    4312
XP_005272533                                                           17    4312
XP_005272532                                                           17    4312
NP_037379                                                              16    5631
NP_659540                                                              16    5631
NP_060098                                                              16    5631
NP_001120680                                                           16    5631
NP_060127                                                              16    5631
XP_006714306                                                           16    5631
XP_006714305                                                           16    5631
XP_005263139                                                           16    5631
XP_005264437                                                           16    5631
XP_005264323                                                           16    5631
NP_982261                                                              16    5631
NP_001002243                                                           16    5631
NP_001268231                                                           16    7355
NP_115756                                                              16    7355
NP_733792                                                              16    7355
NP_733781                                                              16    7355
XP_006714784                                                           16    7355
NP_002825                                                              15    9605
NP_001272390                                                           15    9605
NP_006624                                                              15    9605
NP_001272391                                                           15    9605
NP_001272389                                                           15    9605
NP_001003703                                                           15    9605
NP_001003697                                                           15    9605
NP_001676                                                              15    9605
NP_001003696                                                           15    9605
NP_001003701                                                           15    9605
NP_003861                                                              15    9605
NP_061060                                                              15    9605
XP_005261049                                                           15    9605
XP_006719590                                                           15    9605
XP_006719589                                                           15    9605
XP_005271878                                                           15    9605
XP_005271877                                                           15    9605
XP_005271876                                                           15    9605
XP_005248471                                                           15    9605
XP_005248470                                                           15    9605
XP_006714585                                                           15    9605
XP_005248468                                                           15    9605
XP_005248467                                                           15    9605
XP_005248466                                                           15    9605
>NP_115803
          Length = 1156

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QRRNVGIMQ 9
           QRRNVG MQ
Sbjct: 804 QRRNVGNMQ 812
>NP_001158184
          Length = 386

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRRNVGIM 8
           QRR VG+M
Sbjct: 317 QRRRVGLM 324
>NP_000472
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRRNVGIM 8
           QRR VG+M
Sbjct: 317 QRRRVGLM 324
>NP_065988
          Length = 2048

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    QRRNVGI 7
            QR+NVGI
Sbjct: 1953 QRKNVGI 1959
>NP_001158182
          Length = 359

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRRNVGIM 8
           QRR VG+M
Sbjct: 273 QRRRVGLM 280
>NP_001158183
          Length = 347

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRRNVGIM 8
           QRR VG+M
Sbjct: 261 QRRRVGLM 268
>XP_005267986
          Length = 2022

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    QRRNVGI 7
            QR+NVGI
Sbjct: 1927 QRKNVGI 1933
>NP_001128662
          Length = 1133

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRNVGIMQ 9
           RRNVGI +
Sbjct: 903 RRNVGIRE 910
>NP_056057
          Length = 1205

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRNVGIMQ 9
           RRNVGI +
Sbjct: 964 RRNVGIRE 971
>NP_001035207
          Length = 1450

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RRNVGIMQ 9
            RRNVGI +
Sbjct: 1209 RRNVGIRE 1216
>NP_036467
          Length = 1098

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRRNVGIM 8
           QR+N+G+M
Sbjct: 221 QRQNLGLM 228
>XP_005272534
          Length = 1071

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRRNVGIM 8
           QR+N+G+M
Sbjct: 221 QRQNLGLM 228
>XP_005272533
          Length = 1096

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRRNVGIM 8
           QR+N+G+M
Sbjct: 221 QRQNLGLM 228
>XP_005272532
          Length = 1100

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRRNVGIM 8
           QR+N+G+M
Sbjct: 221 QRQNLGLM 228
>NP_037379
          Length = 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QRRNVGIM 8
           QRR +G+M
Sbjct: 358 QRRYIGVM 365
>NP_659540
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QRRNVGIM 8
           QRR +G+M
Sbjct: 293 QRRYIGVM 300
>NP_060098
          Length = 1165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QRRNVGIMQ 9
           +RRN G+ Q
Sbjct: 121 ERRNFGVSQ 129
>NP_001120680
          Length = 2002

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QRRNVGIMQ 9
           +RRN G+ Q
Sbjct: 121 ERRNFGVSQ 129
>NP_060127
          Length = 909

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QRRNVGIMQ 9
           QR+NVG ++
Sbjct: 140 QRQNVGTLE 148
>XP_006714306
          Length = 1167

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QRRNVGIMQ 9
           +RRN G+ Q
Sbjct: 121 ERRNFGVSQ 129
>XP_006714305
          Length = 1902

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QRRNVGIMQ 9
           +RRN G+ Q
Sbjct: 121 ERRNFGVSQ 129
>XP_005263139
          Length = 2002

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QRRNVGIMQ 9
           +RRN G+ Q
Sbjct: 121 ERRNFGVSQ 129
>XP_005264437
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QRRNVGIMQ 9
           QR+NVG ++
Sbjct: 140 QRQNVGTLE 148
>XP_005264323
          Length = 426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QRRNVGIM 8
           QRR +G+M
Sbjct: 358 QRRYIGVM 365
>NP_982261
          Length = 936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QRRNVGIMQ 9
           QR+NVG ++
Sbjct: 140 QRQNVGTLE 148
>NP_001002243
          Length = 908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QRRNVGIMQ 9
           QR+NVG ++
Sbjct: 140 QRQNVGTLE 148
>NP_001268231
          Length = 811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RNVGIM 8
           RN+GIM
Sbjct: 103 RNIGIM 108
>NP_115756
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RNVGIM 8
          RN+GIM
Sbjct: 71 RNIGIM 76
>NP_733792
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RNVGIM 8
          RN+GIM
Sbjct: 71 RNIGIM 76
>NP_733781
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RNVGIM 8
          RN+GIM
Sbjct: 71 RNIGIM 76
>XP_006714784
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RNVGIM 8
          RN+GIM
Sbjct: 71 RNIGIM 76
>NP_002825
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVGIMQ 9
           NVG+MQ
Sbjct: 582 NVGLMQ 587
>NP_001272390
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRRNVG 6
           QRRN+G
Sbjct: 630 QRRNLG 635
>NP_006624
          Length = 1575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QRRNVG 6
            QRRN+G
Sbjct: 1134 QRRNLG 1139
>NP_001272391
          Length = 1071

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRRNVG 6
           QRRN+G
Sbjct: 630 QRRNLG 635
>NP_001272389
          Length = 1525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QRRNVG 6
            QRRN+G
Sbjct: 1084 QRRNLG 1089
>NP_001003703
          Length = 108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  RRNVGI 7
          RRN+G+
Sbjct: 22 RRNIGV 27
>NP_001003697
          Length = 108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  RRNVGI 7
          RRN+G+
Sbjct: 22 RRNIGV 27
>NP_001676
          Length = 108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  RRNVGI 7
          RRN+G+
Sbjct: 22 RRNIGV 27
>NP_001003696
          Length = 108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  RRNVGI 7
          RRN+G+
Sbjct: 22 RRNIGV 27
>NP_001003701
          Length = 116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  RRNVGI 7
          RRN+G+
Sbjct: 30 RRNIGV 35
>NP_003861
          Length = 1657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QRRNVG 6
            QRRN+G
Sbjct: 1221 QRRNLG 1226
>NP_061060
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRRNVG 6
           +RRNVG
Sbjct: 98  ERRNVG 103
>XP_005261049
          Length = 108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  RRNVGI 7
          RRN+G+
Sbjct: 22 RRNIGV 27
>XP_006719590
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVGIMQ 9
           NVG+MQ
Sbjct: 548 NVGLMQ 553
>XP_006719589
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NVGIMQ 9
           NVG+MQ
Sbjct: 586 NVGLMQ 591
>XP_005271878
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRRNVG 6
           +RRNVG
Sbjct: 98  ERRNVG 103
>XP_005271877
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRRNVG 6
           +RRNVG
Sbjct: 98  ERRNVG 103
>XP_005271876
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRRNVG 6
           +RRNVG
Sbjct: 98  ERRNVG 103
>XP_005248471
          Length = 1128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QRRNVG 6
           QRRN+G
Sbjct: 687 QRRNLG 692
>XP_005248470
          Length = 1518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QRRNVG 6
            QRRN+G
Sbjct: 1077 QRRNLG 1082
>XP_006714585
          Length = 1525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QRRNVG 6
            QRRN+G
Sbjct: 1084 QRRNLG 1089
>XP_005248468
          Length = 1548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QRRNVG 6
            QRRN+G
Sbjct: 1107 QRRNLG 1112
>XP_005248467
          Length = 1548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QRRNVG 6
            QRRN+G
Sbjct: 1107 QRRNLG 1112
>XP_005248466
          Length = 1565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    QRRNVG 6
            QRRN+G
Sbjct: 1124 QRRNLG 1129
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.139    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 437,595
Number of extensions: 573
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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