Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              20     390
NP_005913                                                              20     390
XP_005267046                                                           20     390
XP_005267045                                                           20     390
NP_000625                                                              17    2528
NP_005092                                                              17    4312
NP_699192                                                              16    5631
NP_001243779                                                           16    5631
NP_596869                                                              16    5631
XP_006716298                                                           16    5631
XP_006716297                                                           16    5631
XP_006714514                                                           16    5631
XP_006714513                                                           16    5631
XP_006712787                                                           16    5631
XP_006712786                                                           16    5631
NP_001254479                                                           16    5631
NP_001177203                                                           16    7355
NP_005392                                                              16    7355
NP_054889                                                              16    7355
NP_055703                                                              16    7355
NP_663771                                                              16    7355
NP_620160                                                              16    7355
NP_001035109                                                           16    7355
NP_874362                                                              16    7355
XP_006714215                                                           16    7355
XP_006714214                                                           16    7355
XP_005262915                                                           16    7355
XP_006713030                                                           16    7355
XP_006713029                                                           16    7355
XP_005264921                                                           16    7355
XP_005264920                                                           16    7355
XP_006713028                                                           16    7355
XP_005264919                                                           16    7355
XP_005264631                                                           16    7355
XP_005264630                                                           16    7355
XP_005264629                                                           16    7355
NP_055806                                                              16    7355
NP_001078853                                                           15    9605
NP_665682                                                              15    9605
NP_663160                                                              15    9605
NP_663162                                                              15    9605
NP_056365                                                              15    9605
NP_899243                                                              15    9605
NP_663161                                                              15    9605
NP_001188410                                                           15    9605
NP_115912                                                              15    9605
NP_001188411                                                           15    9605
NP_001188409                                                           15    9605
NP_665741                                                              15    9605
XP_003403542                                                           15    9605
XP_006723427                                                           15    9605
XP_005257067                                                           15    9605
XP_006720135                                                           15    9605
XP_006720134                                                           15    9605
XP_006720133                                                           15    9605
XP_006715747                                                           15    9605
XP_006715746                                                           15    9605
XP_006715745                                                           15    9605
XP_006715744                                                           15    9605
XP_005249755                                                           15    9605
XP_006713282                                                           15    9605
XP_006713281                                                           15    9605
XP_005265326                                                           15    9605
XP_005265323                                                           15    9605
XP_006712295                                                           15    9605
XP_006712294                                                           15    9605
XP_003403793                                                           15    9605
>NP_006715
          Length = 1558

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QRNNVGRSA 9
           QRNNVGR A
Sbjct: 100 QRNNVGRPA 108
>NP_005913
          Length = 1608

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QRNNVGRSA 9
           QRNNVGR A
Sbjct: 100 QRNNVGRPA 108
>XP_005267046
          Length = 1554

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QRNNVGRSA 9
           QRNNVGR A
Sbjct: 100 QRNNVGRPA 108
>XP_005267045
          Length = 1604

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QRNNVGRSA 9
           QRNNVGR A
Sbjct: 100 QRNNVGRPA 108
>NP_000625
          Length = 350

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRNNVGRS 8
           +RNN+GR+
Sbjct: 279 RRNNIGRA 286
>NP_005092
          Length = 165

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RNNVGRSA 9
          RNN GRS+
Sbjct: 87 RNNKGRSS 94
>NP_699192
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RNNVGRSA 9
           RNN GR A
Sbjct: 372 RNNQGRDA 379
>NP_001243779
          Length = 34350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +NNVG+S+
Sbjct: 6706 QNNVGKSS 6713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +N+VGRS+
Sbjct: 5581 QNDVGRSS 5588
>NP_596869
          Length = 33423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +NNVG+S+
Sbjct: 5779 QNNVGKSS 5786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +N+VGRS+
Sbjct: 4654 QNDVGRSS 4661
>XP_006716298
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RNNVGRSA 9
           RN +GRS+
Sbjct: 426 RNQIGRSS 433
>XP_006716297
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RNNVGRSA 9
           RN +GRS+
Sbjct: 426 RNQIGRSS 433
>XP_006714514
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RNNVGRSA 9
           RNN GR A
Sbjct: 248 RNNQGRDA 255
>XP_006714513
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RNNVGRSA 9
           RNN GR A
Sbjct: 372 RNNQGRDA 379
>XP_006712787
          Length = 33978

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +NNVG+S+
Sbjct: 6707 QNNVGKSS 6714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +N+VGRS+
Sbjct: 5582 QNDVGRSS 5589
>XP_006712786
          Length = 35484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +NNVG+S+
Sbjct: 6707 QNNVGKSS 6714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +N+VGRS+
Sbjct: 5582 QNDVGRSS 5589
>NP_001254479
          Length = 35991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +NNVG+S+
Sbjct: 7023 QNNVGKSS 7030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RNNVGRSA 9
            +N+VGRS+
Sbjct: 5898 QNDVGRSS 5905
>NP_001177203
          Length = 927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QRNNVG 6
          +RNNVG
Sbjct: 70 ERNNVG 75
>NP_005392
          Length = 1187

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RNNVGRSA 9
           RN +GR A
Sbjct: 242 RNRIGRQA 249
>NP_054889
          Length = 284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RNNVGRSA 9
           R+NVG+S+
Sbjct: 118 RSNVGKSS 125
>NP_055703
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           +NNVGR
Sbjct: 97  KNNVGR 102
>NP_663771
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QRNNVGRSA 9
           +RNNVG  A
Sbjct: 129 RRNNVGFGA 137
>NP_620160
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RNNVGR 7
          +NNVGR
Sbjct: 94 KNNVGR 99
>NP_001035109
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           +NNVGR
Sbjct: 97  KNNVGR 102
>NP_874362
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  QRNNVGR 7
          ++NNVGR
Sbjct: 24 RQNNVGR 30

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RNNVGRSA 9
          RN+VGR A
Sbjct: 44 RNHVGRVA 51
>XP_006714215
          Length = 3544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NVGRSA 9
            NVGRSA
Sbjct: 1750 NVGRSA 1755
>XP_006714214
          Length = 3544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NVGRSA 9
            NVGRSA
Sbjct: 1750 NVGRSA 1755
>XP_005262915
          Length = 3544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NVGRSA 9
            NVGRSA
Sbjct: 1750 NVGRSA 1755
>XP_006713030
          Length = 187

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RNNVGR 7
          +NNVGR
Sbjct: 57 KNNVGR 62
>XP_006713029
          Length = 188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RNNVGR 7
          +NNVGR
Sbjct: 58 KNNVGR 63
>XP_005264921
          Length = 223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RNNVGR 7
          +NNVGR
Sbjct: 93 KNNVGR 98
>XP_005264920
          Length = 223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RNNVGR 7
          +NNVGR
Sbjct: 93 KNNVGR 98
>XP_006713028
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RNNVGR 7
          +NNVGR
Sbjct: 94 KNNVGR 99
>XP_005264919
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RNNVGR 7
          +NNVGR
Sbjct: 94 KNNVGR 99
>XP_005264631
          Length = 926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QRNNVG 6
          +RNNVG
Sbjct: 70 ERNNVG 75
>XP_005264630
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QRNNVG 6
          +RNNVG
Sbjct: 70 ERNNVG 75
>XP_005264629
          Length = 954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QRNNVG 6
          +RNNVG
Sbjct: 70 ERNNVG 75
>NP_055806
          Length = 3526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    NVGRSA 9
            NVGRSA
Sbjct: 1732 NVGRSA 1737
>NP_001078853
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RNNVGRS 8
          R+NVGR+
Sbjct: 68 RSNVGRA 74
>NP_665682
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 580 RNNIGK 585
>NP_663160
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 502 RNNIGK 507
>NP_663162
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 466 RNNIGK 471
>NP_056365
          Length = 887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 533 RNNIGK 538
>NP_899243
          Length = 1977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    QRNNVGR 7
            Q NNVG+
Sbjct: 1357 QTNNVGK 1363
>NP_663161
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 497 RNNIGK 502
>NP_001188410
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 545 RNNIGK 550
>NP_115912
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 576 RNNIGK 581
>NP_001188411
          Length = 898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 540 RNNIGK 545
>NP_001188409
          Length = 959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 601 RNNIGK 606
>NP_665741
          Length = 842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 484 RNNIGK 489
>XP_003403542
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RNNVGRS 8
           +N+VGRS
Sbjct: 458 KNDVGRS 464
>XP_006723427
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RNNVGRS 8
           R+NVGR+
Sbjct: 105 RSNVGRA 111
>XP_005257067
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 484 RNNIGK 489
>XP_006720135
          Length = 1454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    QRNNVGR 7
            Q NNVG+
Sbjct: 1349 QTNNVGK 1355
>XP_006720134
          Length = 1579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    QRNNVGR 7
            Q NNVG+
Sbjct: 1349 QTNNVGK 1355
>XP_006720133
          Length = 1969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    QRNNVGR 7
            Q NNVG+
Sbjct: 1349 QTNNVGK 1355
>XP_006715747
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 180 RNNIGK 185
>XP_006715746
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 466 RNNIGK 471
>XP_006715745
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 497 RNNIGK 502
>XP_006715744
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 502 RNNIGK 507
>XP_005249755
          Length = 887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 533 RNNIGK 538
>XP_006713282
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QRNNVGRS 8
           Q+N VGR+
Sbjct: 341 QQNGVGRA 348
>XP_006713281
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QRNNVGRS 8
           Q+N VGR+
Sbjct: 468 QQNGVGRA 475
>XP_005265326
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QRNNVGRS 8
           Q+N VGR+
Sbjct: 508 QQNGVGRA 515
>XP_005265323
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QRNNVGRS 8
           Q+N VGR+
Sbjct: 535 QQNGVGRA 542
>XP_006712295
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 565 RNNIGK 570
>XP_006712294
          Length = 928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RNNVGR 7
           RNN+G+
Sbjct: 570 RNNIGK 575
>XP_003403793
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RNNVGRS 8
           +N+VGRS
Sbjct: 458 KNDVGRS 464
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.119    0.313 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 528,007
Number of extensions: 1007
Number of successful extensions: 73
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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