Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001156685                                                           21     175
NP_000133                                                              21     175
NP_075254                                                              21     175
XP_006713936                                                           21     175
XP_006713935                                                           21     175
XP_006713934                                                           21     175
XP_006713933                                                           21     175
XP_006713932                                                           21     175
XP_006713931                                                           21     175
NP_001032409                                                           17    2528
NP_001032410                                                           17    2528
NP_055191                                                              17    2528
NP_060356                                                              17    3301
XP_005265319                                                           17    3301
XP_006713278                                                           17    3301
XP_005265318                                                           17    3301
NP_005421                                                              17    4312
NP_612393                                                              17    4312
NP_006356                                                              17    4312
XP_005268923                                                           17    4312
XP_006711182                                                           17    4312
XP_005244889                                                           17    4312
NP_001935                                                              17    4312
NP_000419                                                              16    5631
NP_055680                                                              16    5631
XP_006713909                                                           16    5631
NP_075573                                                              16    7355
NP_075571                                                              16    7355
NP_699167                                                              16    7355
NP_001093156                                                           16    7355
NP_071336                                                              16    7355
NP_005952                                                              16    7355
NP_001919                                                              16    7355
NP_001001661                                                           16    7355
XP_006725823                                                           16    7355
XP_006725595                                                           16    7355
XP_005269553                                                           16    7355
NP_001135946                                                           16    7355
NP_001135947                                                           16    7355
NP_078853                                                              15    9605
NP_004711                                                              15    9605
NP_073744                                                              15    9605
NP_001030611                                                           15    9605
NP_060587                                                              15    9605
NP_001139131                                                           15    9605
NP_892018                                                              15    9605
NP_071736                                                              15    9605
NP_001074002                                                           15    9605
NP_001271192                                                           15    9605
NP_775781                                                              15    9605
NP_036225                                                              15    9605
NP_777283                                                              15    9605
XP_005259608                                                           15    9605
XP_005270021                                                           15    9605
XP_005270020                                                           15    9605
XP_005270019                                                           15    9605
XP_005252192                                                           15    9605
XP_006710635                                                           15    9605
XP_005270796                                                           15    9605
>NP_001156685
          Length = 808

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QRLTERVLC 9
           QRLT+RVLC
Sbjct: 111 QRLTQRVLC 119
>NP_000133
          Length = 806

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QRLTERVLC 9
           QRLT+RVLC
Sbjct: 111 QRLTQRVLC 119
>NP_075254
          Length = 694

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QRLTERVLC 9
           QRLT+RVLC
Sbjct: 111 QRLTQRVLC 119
>XP_006713936
          Length = 807

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QRLTERVLC 9
           QRLT+RVLC
Sbjct: 111 QRLTQRVLC 119
>XP_006713935
          Length = 807

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QRLTERVLC 9
           QRLT+RVLC
Sbjct: 111 QRLTQRVLC 119
>XP_006713934
          Length = 809

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QRLTERVLC 9
           QRLT+RVLC
Sbjct: 111 QRLTQRVLC 119
>XP_006713933
          Length = 810

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QRLTERVLC 9
           QRLT+RVLC
Sbjct: 111 QRLTQRVLC 119
>XP_006713932
          Length = 810

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QRLTERVLC 9
           QRLT+RVLC
Sbjct: 111 QRLTQRVLC 119
>XP_006713931
          Length = 811

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QRLTERVLC 9
           QRLT+RVLC
Sbjct: 111 QRLTQRVLC 119
>NP_001032409
          Length = 1253

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTERVLC 9
           RLT R+LC
Sbjct: 805 RLTHRLLC 812
>NP_001032410
          Length = 1253

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTERVLC 9
           RLT R+LC
Sbjct: 805 RLTHRLLC 812
>NP_055191
          Length = 1253

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLTERVLC 9
           RLT R+LC
Sbjct: 805 RLTHRLLC 812
>NP_060356
          Length = 1275

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTERVLC 9
           LTE++LC
Sbjct: 227 LTEKILC 233
>XP_005265319
          Length = 897

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTERVLC 9
           LTE++LC
Sbjct: 227 LTEKILC 233
>XP_006713278
          Length = 1156

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTERVLC 9
           LTE++LC
Sbjct: 108 LTEKILC 114
>XP_005265318
          Length = 1274

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTERVLC 9
           LTE++LC
Sbjct: 227 LTEKILC 233
>NP_005421
          Length = 370

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QRLTERVLC 9
           QR+TER  C
Sbjct: 339 QRVTERCNC 347
>NP_612393
          Length = 334

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2 RLTERVLC 9
         RLT R LC
Sbjct: 2 RLTPRALC 9
>NP_006356
          Length = 156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RLTERVLC 9
          R TER LC
Sbjct: 75 RCTERCLC 82
>XP_005268923
          Length = 563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  QRLTERVLC 9
          +RLT R LC
Sbjct: 51 ERLTPRPLC 59
>XP_006711182
          Length = 156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RLTERVLC 9
          R TER LC
Sbjct: 75 RCTERCLC 82
>XP_005244889
          Length = 109

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RLTERVLC 9
          R TER LC
Sbjct: 58 RCTERCLC 65
>NP_001935
          Length = 999

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTERVLC 9
           +TERV+C
Sbjct: 961 VTERVIC 967
>NP_000419
          Length = 1821

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   QRLTERVLC 9
           QR+T+++ C
Sbjct: 689 QRITKQICC 697
>NP_055680
          Length = 1401

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QRLTERVLC 9
           +R TE+V C
Sbjct: 758 ERATEKVAC 766
>XP_006713909
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTERVLC 9
           +TERV+C
Sbjct: 253 VTERVVC 259
>NP_075573
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TERVLC 9
           TER+LC
Sbjct: 332 TERLLC 337
>NP_075571
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TERVLC 9
           TER+LC
Sbjct: 332 TERLLC 337
>NP_699167
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   QRLTERVLC 9
           Q+ T+R++C
Sbjct: 260 QKDTDRIIC 268
>NP_001093156
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TERVLC 9
           TER+LC
Sbjct: 492 TERMLC 497
>NP_071336
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TERVLC 9
           TER+LC
Sbjct: 492 TERMLC 497
>NP_005952
          Length = 2439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTERVLC 9
           LTE V+C
Sbjct: 911 LTENVIC 917
>NP_001919
          Length = 253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTERVLC 9
           +TER++C
Sbjct: 189 ITERLMC 195
>NP_001001661
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RLTERVLC 9
           R T+R+LC
Sbjct: 234 RRTQRLLC 241
>XP_006725823
          Length = 1825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTERVLC 9
           LTE V+C
Sbjct: 911 LTENVIC 917
>XP_006725595
          Length = 1311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LTERVLC 9
           LTE V+C
Sbjct: 911 LTENVIC 917
>XP_005269553
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   QRLTERVLC 9
           Q+ T+R++C
Sbjct: 260 QKDTDRIIC 268
>NP_001135946
          Length = 102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RLTERVLC 9
          R+T+RV C
Sbjct: 23 RMTDRVPC 30
>NP_001135947
          Length = 112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RLTERVLC 9
          R+T+RV C
Sbjct: 23 RMTDRVPC 30
>NP_078853
          Length = 1288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RLTERVLC 9
           R T+R LC
Sbjct: 753 RSTQRALC 760
>NP_004711
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QRLTERVLC 9
           QR+ E V C
Sbjct: 220 QRMAEHVSC 228
>NP_073744
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRLTERVL 8
           QR+ ERVL
Sbjct: 470 QRVLERVL 477
>NP_001030611
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRLTERVL 8
           QR+ ERVL
Sbjct: 457 QRVLERVL 464
>NP_060587
          Length = 1224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QRLTERVLC 9
           Q LTE V C
Sbjct: 835 QELTEPVWC 843
>NP_001139131
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRLTERVL 8
           Q+LTER L
Sbjct: 488 QKLTEREL 495
>NP_892018
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTERVLC 9
           LT+R++C
Sbjct: 666 LTDRMIC 672
>NP_071736
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QRLTERVL 8
           QRLT+R++
Sbjct: 93  QRLTQRLV 100
>NP_001074002
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  RLTERVLC 9
          R+TE  LC
Sbjct: 78 RVTENYLC 85
>NP_001271192
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QRLTERVLC 9
          +R+TE  LC
Sbjct: 68 KRITEAELC 76
>NP_775781
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  QRLTERVLC 9
          +R+TE  LC
Sbjct: 86 KRITEAELC 94
>NP_036225
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRLTERVL 8
           QRL ER+L
Sbjct: 222 QRLKERLL 229
>NP_777283
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRLTERVL 8
           QRL ER+L
Sbjct: 248 QRLKERLL 255
>XP_005259608
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LTERVLC 9
           LT+R++C
Sbjct: 700 LTDRMIC 706
>XP_005270021
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QRLTERVLC 9
           Q LTE V C
Sbjct: 364 QELTEPVWC 372
>XP_005270020
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QRLTERVLC 9
           Q LTE V C
Sbjct: 576 QELTEPVWC 584
>XP_005270019
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   QRLTERVLC 9
           Q LTE V C
Sbjct: 576 QELTEPVWC 584
>XP_005252192
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRLTERVL 8
           QR+ ERVL
Sbjct: 459 QRVLERVL 466
>XP_006710635
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRLTERVL 8
           QRL ER+L
Sbjct: 222 QRLKERLL 229
>XP_005270796
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QRLTERVL 8
           QRL ER+L
Sbjct: 224 QRLKERLL 231
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.141    0.431 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 489,593
Number of extensions: 917
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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