Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001121619                                                           18    1135
NP_000258                                                              18    1135
NP_001035957                                                           18    1135
XP_006721991                                                           18    1135
XP_006721990                                                           18    1135
XP_006721989                                                           18    1135
XP_005258041                                                           18    1135
XP_006721988                                                           18    1135
XP_006721987                                                           18    1135
XP_006721986                                                           18    1135
XP_005258040                                                           18    1135
XP_006721985                                                           18    1135
NP_872288                                                              17    4312
NP_872287                                                              17    4312
NP_006026                                                              16    5631
XP_005268287                                                           16    5631
XP_005268286                                                           16    5631
XP_005268285                                                           16    5631
XP_005268284                                                           16    5631
NP_055935                                                              16    7355
NP_001073379                                                           16    7355
NP_001009959                                                           16    7355
NP_065762                                                              16    7355
XP_006719697                                                           16    7355
XP_006719696                                                           16    7355
XP_006719695                                                           16    7355
XP_005269238                                                           16    7355
NP_065861                                                              15    9605
NP_001157871                                                           15    9605
NP_001243064                                                           15    9605
NP_001307                                                              15    9605
XP_005267973                                                           15    9605

>NP_001121619
          Length = 593

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>NP_000258
          Length = 2818

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>NP_001035957
          Length = 2839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>XP_006721991
          Length = 1632

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>XP_006721990
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>XP_006721989
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>XP_005258041
          Length = 2836

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>XP_006721988
          Length = 2846

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>XP_006721987
          Length = 2849

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>XP_006721986
          Length = 2854

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 14 QQNTHTKVS 22



>XP_005258040
          Length = 2857

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>XP_006721985
          Length = 2867

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  QQNTLTKVS 9
          QQNT TKVS
Sbjct: 27 QQNTHTKVS 35



>NP_872288
          Length = 109

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QNTLTKV 8
          QNTLTK+
Sbjct: 84 QNTLTKL 90



>NP_872287
          Length = 109

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  QNTLTKV 8
          QNTLTK+
Sbjct: 84 QNTLTKL 90



>NP_006026
          Length = 1711

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   QQNTLTK 7
           Q NTLTK
Sbjct: 420 QSNTLTK 426



>XP_005268287
          Length = 1490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   QQNTLTK 7
           Q NTLTK
Sbjct: 420 QSNTLTK 426



>XP_005268286
          Length = 1685

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   QQNTLTK 7
           Q NTLTK
Sbjct: 420 QSNTLTK 426



>XP_005268285
          Length = 1702

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   QQNTLTK 7
           Q NTLTK
Sbjct: 420 QSNTLTK 426



>XP_005268284
          Length = 1728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   QQNTLTK 7
           Q NTLTK
Sbjct: 420 QSNTLTK 426



>NP_055935
          Length = 4169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QNTLTKVS 9
           + TLTKVS
Sbjct: 738 EETLTKVS 745



>NP_001073379
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QNTLTKV 8
            QN+LTK+
Sbjct: 1068 QNSLTKI 1074



>NP_001009959
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  QNTLTKVS 9
          Q T+TK+S
Sbjct: 36 QQTITKIS 43



>NP_065762
          Length = 284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  QNTLTKVS 9
          Q T+TK+S
Sbjct: 23 QQTITKIS 30



>XP_006719697
          Length = 1658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QNTLTKV 8
            QN+LTK+
Sbjct: 1004 QNSLTKI 1010



>XP_006719696
          Length = 1696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QNTLTKV 8
            QN+LTK+
Sbjct: 1004 QNSLTKI 1010



>XP_006719695
          Length = 1696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QNTLTKV 8
            QN+LTK+
Sbjct: 1004 QNSLTKI 1010



>XP_005269238
          Length = 1696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QNTLTKV 8
            QN+LTK+
Sbjct: 1004 QNSLTKI 1010



>NP_065861
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QQNTLTKV 8
           +QN +TKV
Sbjct: 258 EQNMMTKV 265



>NP_001157871
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QQNTLTK 7
           ++NTLTK
Sbjct: 787 EKNTLTK 793



>NP_001243064
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   QNTLTKV 8
           QNTLT +
Sbjct: 281 QNTLTSI 287



>NP_001307
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   QNTLTKV 8
           QNTLT +
Sbjct: 337 QNTLTSI 343



>XP_005267973
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QQNTLTKV 8
           +QN +TKV
Sbjct: 286 EQNMMTKV 293



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.104    0.239 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 338,021
Number of extensions: 339
Number of successful extensions: 32
Number of sequences better than 10000.0: 32
Number of HSP's gapped: 32
Number of HSP's successfully gapped: 32
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)