Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              18    1135
NP_073572                                                              17    4312
NP_004566                                                              16    5631
NP_071428                                                              16    7355
NP_001253967                                                           16    7355
XP_006714731                                                           16    7355
NP_899200                                                              15    9605
NP_001186571                                                           15    9605
NP_071347                                                              15    9605
NP_056085                                                              15    9605
XP_006719760                                                           15    9605
XP_006719759                                                           15    9605
XP_006719758                                                           15    9605
XP_005254048                                                           15    9605
XP_006719757                                                           15    9605
XP_006719276                                                           15    9605
XP_006719275                                                           15    9605
XP_006719274                                                           15    9605
XP_006719273                                                           15    9605
XP_005268662                                                           15    9605
XP_006719272                                                           15    9605
XP_006713547                                                           15    9605
XP_006713546                                                           15    9605
XP_005247135                                                           15    9605
XP_005247134                                                           15    9605
XP_006713348                                                           15    9605
NP_997194                                                              15    9605
NP_066193                                                              15    9605
>NP_000312
          Length = 928

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QQLMMSLNS 9
           QQLMM LNS
Sbjct: 383 QQLMMILNS 391
>NP_073572
          Length = 528

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QQLMMSLNS 9
           QQ+M +LNS
Sbjct: 244 QQIMAALNS 252
>NP_004566
          Length = 409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3 LMMSLNS 9
         +MMSLNS
Sbjct: 2 MMMSLNS 8
>NP_071428
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QQLMMSLN 8
           QQ+M SLN
Sbjct: 133 QQIMESLN 140
>NP_001253967
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QQLMMSLN 8
           QQ+M SLN
Sbjct: 133 QQIMESLN 140
>XP_006714731
          Length = 225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QQLMMSLN 8
           QQ+M SLN
Sbjct: 133 QQIMESLN 140
>NP_899200
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 488 QELVMTLN 495
>NP_001186571
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 138 QELVMTLN 145
>NP_071347
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QQLMMSL 7
           +QLMMSL
Sbjct: 379 KQLMMSL 385
>NP_056085
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 398 QELVMTLN 405
>XP_006719760
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MMSLNS 9
           MMSLNS
Sbjct: 426 MMSLNS 431
>XP_006719759
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MMSLNS 9
           MMSLNS
Sbjct: 499 MMSLNS 504
>XP_006719758
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MMSLNS 9
           MMSLNS
Sbjct: 547 MMSLNS 552
>XP_005254048
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MMSLNS 9
           MMSLNS
Sbjct: 543 MMSLNS 548
>XP_006719757
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MMSLNS 9
           MMSLNS
Sbjct: 547 MMSLNS 552
>XP_006719276
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 430 QELVMTLN 437
>XP_006719275
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 430 QELVMTLN 437
>XP_006719274
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 430 QELVMTLN 437
>XP_006719273
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 398 QELVMTLN 405
>XP_005268662
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 398 QELVMTLN 405
>XP_006719272
          Length = 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 430 QELVMTLN 437
>XP_006713547
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  QQLMMSLN 8
          Q+L+M+LN
Sbjct: 47 QELVMTLN 54
>XP_006713546
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 121 QELVMTLN 128
>XP_005247135
          Length = 936

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 138 QELVMTLN 145
>XP_005247134
          Length = 1286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 488 QELVMTLN 495
>XP_006713348
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   QQLMMSL 7
           +QLMMSL
Sbjct: 379 KQLMMSL 385
>NP_997194
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   MMSLNS 9
           MMSLNS
Sbjct: 495 MMSLNS 500
>NP_066193
          Length = 1115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   QQLMMSLN 8
           Q+L+M+LN
Sbjct: 398 QELVMTLN 405
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.114    0.258 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 282,755
Number of extensions: 456
Number of successful extensions: 28
Number of sequences better than 10000.0: 28
Number of HSP's gapped: 28
Number of HSP's successfully gapped: 28
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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