Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              21     229
NP_733762                                                              18    1935
XP_006713860                                                           18    1935
XP_006713859                                                           18    1935
XP_005247910                                                           18    1935
XP_005247909                                                           18    1935
NP_001269607                                                           17    2528
NP_001269606                                                           17    2528
NP_000457                                                              17    2528
NP_001273205                                                           17    4312
NP_001273203                                                           17    4312
NP_065982                                                              17    4312
NP_001273204                                                           17    4312
NP_055267                                                              16    5631
NP_689418                                                              16    5631
NP_000294                                                              16    7355
NP_003795                                                              16    7355
NP_006280                                                              16    7355
NP_003164                                                              16    7355
NP_001269095                                                           16    7355
XP_005255429                                                           16    7355
XP_006716915                                                           16    7355
XP_005251621                                                           16    7355
XP_005249515                                                           16    7355
XP_006715299                                                           16    7355
XP_005249514                                                           16    7355
XP_006712555                                                           16    7355
XP_006712554                                                           16    7355
XP_005263717                                                           16    7355
XP_005263716                                                           16    7355
XP_006712553                                                           16    7355
NP_997246                                                              16    7355
NP_619542                                                              15    9605
NP_005453                                                              15    9605
NP_001273484                                                           15    9605
NP_057333                                                              15    9605
NP_056003                                                              15    9605
NP_680781                                                              15    9605
NP_680780                                                              15    9605
NP_037396                                                              15    9605
NP_001273759                                                           15    9605
NP_079040                                                              15    9605
NP_059867                                                              15    9605
NP_001073873                                                           15    9605
NP_064570                                                              15    9605
NP_680782                                                              15    9605
NP_663760                                                              15    9605
NP_009176                                                              15    9605
XP_005274600                                                           15    9605
XP_005255134                                                           15    9605
XP_006721076                                                           15    9605
XP_006721075                                                           15    9605
XP_006721074                                                           15    9605
XP_005255133                                                           15    9605
XP_005255132                                                           15    9605
XP_005255131                                                           15    9605
XP_006721073                                                           15    9605
XP_006721072                                                           15    9605
XP_005255129                                                           15    9605
XP_005255128                                                           15    9605
XP_005255127                                                           15    9605
XP_006721071                                                           15    9605
XP_006721070                                                           15    9605
XP_005255126                                                           15    9605
XP_005255125                                                           15    9605
XP_005255124                                                           15    9605
XP_005255123                                                           15    9605
XP_005255122                                                           15    9605
XP_005255121                                                           15    9605
XP_005255120                                                           15    9605
XP_005255119                                                           15    9605
XP_005255118                                                           15    9605
XP_005271586                                                           15    9605
XP_006717795                                                           15    9605
XP_003846820                                                           15    9605
>NP_005179
          Length = 906

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QPRQNLTKL 9
           QPR+NLTKL
Sbjct: 146 QPRRNLTKL 154
>NP_733762
          Length = 982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QPRQNLTKL 9
           Q R+NLTKL
Sbjct: 138 QDRRNLTKL 146
>XP_006713860
          Length = 914

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QPRQNLTKL 9
           Q R+NLTKL
Sbjct: 166 QDRRNLTKL 174
>XP_006713859
          Length = 966

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QPRQNLTKL 9
           Q R+NLTKL
Sbjct: 166 QDRRNLTKL 174
>XP_005247910
          Length = 982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QPRQNLTKL 9
           Q R+NLTKL
Sbjct: 138 QDRRNLTKL 146
>XP_005247909
          Length = 1010

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   QPRQNLTKL 9
           Q R+NLTKL
Sbjct: 166 QDRRNLTKL 174
>NP_001269607
          Length = 1075

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QPRQNLTK 8
           QPR+NL K
Sbjct: 240 QPRENLPK 247
>NP_001269606
          Length = 1226

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QPRQNLTK 8
           QPR+NL K
Sbjct: 448 QPRENLPK 455
>NP_000457
          Length = 1283

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   QPRQNLTK 8
           QPR+NL K
Sbjct: 448 QPRENLPK 455
>NP_001273205
          Length = 720

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QPRQNLTKL 9
           QP +N TKL
Sbjct: 386 QPNKNQTKL 394
>NP_001273203
          Length = 760

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QPRQNLTKL 9
           QP +N TKL
Sbjct: 426 QPNKNQTKL 434
>NP_065982
          Length = 787

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QPRQNLTKL 9
           QP +N TKL
Sbjct: 453 QPNKNQTKL 461
>NP_001273204
          Length = 720

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QPRQNLTKL 9
           QP +N TKL
Sbjct: 386 QPNKNQTKL 394
>NP_055267
          Length = 655

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   PRQNLTK 8
           PRQNL K
Sbjct: 336 PRQNLHK 342
>NP_689418
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   QPRQNLT 7
           QP QN+T
Sbjct: 244 QPNQNMT 250
>NP_000294
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PRQNLTK 8
          PRQ +TK
Sbjct: 20 PRQKITK 26
>NP_003795
          Length = 671

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QPRQN+
Sbjct: 398 QPRQNV 403
>NP_006280
          Length = 2541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           +PRQNL
Sbjct: 632 EPRQNL 637
>NP_003164
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QPRQNL 6
          +PRQNL
Sbjct: 75 EPRQNL 80
>NP_001269095
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QPRQNL 6
          +PRQNL
Sbjct: 86 EPRQNL 91
>XP_005255429
          Length = 270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PRQNLTK 8
          PRQ +TK
Sbjct: 20 PRQKITK 26
>XP_006716915
          Length = 2542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           +PRQNL
Sbjct: 632 EPRQNL 637
>XP_005251621
          Length = 2542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           +PRQNL
Sbjct: 632 EPRQNL 637
>XP_005249515
          Length = 671

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QPRQN+
Sbjct: 398 QPRQNV 403
>XP_006715299
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QPRQN+
Sbjct: 439 QPRQNV 444
>XP_005249514
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QPRQN+
Sbjct: 568 QPRQNV 573
>XP_006712555
          Length = 1786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RQNLTKL 9
           +QNLTK+
Sbjct: 630 KQNLTKI 636
>XP_006712554
          Length = 1885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RQNLTKL 9
           +QNLTK+
Sbjct: 729 KQNLTKI 735
>XP_005263717
          Length = 1953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RQNLTKL 9
           +QNLTK+
Sbjct: 797 KQNLTKI 803
>XP_005263716
          Length = 1953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RQNLTKL 9
           +QNLTK+
Sbjct: 797 KQNLTKI 803
>XP_006712553
          Length = 1953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RQNLTKL 9
           +QNLTK+
Sbjct: 797 KQNLTKI 803
>NP_997246
          Length = 1909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RQNLTKL 9
           +QNLTK+
Sbjct: 797 KQNLTKI 803
>NP_619542
          Length = 1041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  QPRQNLTKL 9
          Q  QNLTK+
Sbjct: 84 QGLQNLTKI 92
>NP_005453
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QPRQNLTKL 9
            +PR+ LTK+
Sbjct: 1039 EPRELLTKV 1047
>NP_001273484
          Length = 205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PRQNLTK 8
          P QNLT+
Sbjct: 59 PSQNLTR 65
>NP_057333
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QPRQNLTKL 9
           +PR+ LTK+
Sbjct: 269 EPRELLTKV 277
>NP_056003
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PRQNLTK 8
           PR+NL K
Sbjct: 352 PRENLQK 358
>NP_680781
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 908 QPQQNL 913
>NP_680780
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 908 QPQQNL 913
>NP_037396
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QPRQNL 6
          QPR+NL
Sbjct: 27 QPRKNL 32
>NP_001273759
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PRQNLTK 8
          PR+ LTK
Sbjct: 13 PREKLTK 19
>NP_079040
          Length = 1116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   PRQNLTK 8
           PR+N+T+
Sbjct: 115 PRENITQ 121
>NP_059867
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 908 QPQQNL 913
>NP_001073873
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  PRQNLTKL 9
          PR+NL +L
Sbjct: 59 PRRNLRRL 66
>NP_064570
          Length = 184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PRQNLTK 8
          P QNLT+
Sbjct: 59 PSQNLTR 65
>NP_680782
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 908 QPQQNL 913
>NP_663760
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 908 QPQQNL 913
>NP_009176
          Length = 1075

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 908 QPQQNL 913
>XP_005274600
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QPRQNLTKL 9
           Q  QNLTK+
Sbjct: 102 QGLQNLTKI 110
>XP_005255134
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 855 QPQQNL 860
>XP_006721076
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_006721075
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_006721074
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005255133
          Length = 1050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 914 QPQQNL 919
>XP_005255132
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005255131
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_006721073
          Length = 1063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_006721072
          Length = 1063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005255129
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 914 QPQQNL 919
>XP_005255128
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005255127
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_006721071
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 885 QPQQNL 890
>XP_006721070
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 891 QPQQNL 896
>XP_005255126
          Length = 1082

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005255125
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005255124
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005255123
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 908 QPQQNL 913
>XP_005255122
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 909 QPQQNL 914
>XP_005255121
          Length = 1103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 914 QPQQNL 919
>XP_005255120
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005255119
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005255118
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QPRQNL 6
           QP+QNL
Sbjct: 915 QPQQNL 920
>XP_005271586
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  QPRQNL 6
          QPR+NL
Sbjct: 27 QPRKNL 32
>XP_006717795
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PRQNLTK 8
           PR+NL K
Sbjct: 445 PRENLQK 451
>XP_003846820
          Length = 1177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QPRQNLTKL 9
            +PR+ LTK+
Sbjct: 1074 EPRELLTKV 1082
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.128    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 622,863
Number of extensions: 982
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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