Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           19     665
NP_858045                                                              19     665
NP_006525                                                              19     665
NP_001167559                                                           19     665
NP_000236                                                              18    1482
NP_001120972                                                           18    1482
XP_006716052                                                           18    1482
XP_006716051                                                           18    1482
NP_001035545                                                           17    4312
NP_071427                                                              16    7355
NP_060082                                                              16    7355
NP_001025226                                                           16    7355
NP_001164                                                              16    7355
XP_005262233                                                           16    7355
XP_005262232                                                           16    7355
XP_005267693                                                           16    7355
XP_005267692                                                           16    7355
XP_006719555                                                           16    7355
XP_005253638                                                           16    7355
XP_006719554                                                           16    7355
NP_056261                                                              15    9605
NP_036440                                                              15    9605
NP_115979                                                              15    9605
NP_001127958                                                           15    9605
NP_443174                                                              15    9605
NP_006142                                                              15    9605
NP_001005366                                                           15    9605
NP_001153574                                                           15    9605
NP_001243334                                                           15    9605
NP_940931                                                              15    9605
NP_001138525                                                           15    9605
XP_005258606                                                           15    9605
XP_006723100                                                           15    9605
XP_006721944                                                           15    9605
XP_006721943                                                           15    9605
XP_006721942                                                           15    9605
XP_005254018                                                           15    9605
XP_005254013                                                           15    9605
XP_005254012                                                           15    9605
XP_005254011                                                           15    9605
XP_006718544                                                           15    9605
XP_006718543                                                           15    9605
XP_006718542                                                           15    9605
XP_006711822                                                           15    9605
XP_006711821                                                           15    9605
NP_653289                                                              15    9605
>NP_001167558
          Length = 1423

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QNRSLLRNS 9
            QNR LLRNS
Sbjct: 1025 QNRPLLRNS 1033
>NP_858045
          Length = 1424

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QNRSLLRNS 9
            QNR LLRNS
Sbjct: 1025 QNRPLLRNS 1033
>NP_006525
          Length = 1420

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QNRSLLRNS 9
            QNR LLRNS
Sbjct: 1025 QNRPLLRNS 1033
>NP_001167559
          Length = 1415

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    QNRSLLRNS 9
            QNR LLRNS
Sbjct: 1020 QNRPLLRNS 1028
>NP_000236
          Length = 1390

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   NRSLLRNS 9
           NR+LLRNS
Sbjct: 399 NRTLLRNS 406
>NP_001120972
          Length = 1408

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   NRSLLRNS 9
           NR+LLRNS
Sbjct: 399 NRTLLRNS 406
>XP_006716052
          Length = 1409

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   NRSLLRNS 9
           NR+LLRNS
Sbjct: 418 NRTLLRNS 425
>XP_006716051
          Length = 1427

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   NRSLLRNS 9
           NR+LLRNS
Sbjct: 418 NRTLLRNS 425
>NP_001035545
          Length = 832

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NRSLLRN 8
           NR+LLRN
Sbjct: 528 NRALLRN 534
>NP_071427
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QNRSLLRNS 9
           +NR  L+NS
Sbjct: 164 ENRDFLKNS 172
>NP_060082
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RSLLRNS 9
           RSLL+NS
Sbjct: 689 RSLLKNS 695
>NP_001025226
          Length = 1502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QNRSLLRNS 9
            QNR  +RNS
Sbjct: 1116 QNRIKIRNS 1124
>NP_001164
          Length = 1501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QNRSLLRNS 9
            QNR  +RNS
Sbjct: 1116 QNRIKIRNS 1124
>XP_005262233
          Length = 193

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QNRSLLRNS 9
           +NR  L+NS
Sbjct: 164 ENRDFLKNS 172
>XP_005262232
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QNRSLLRNS 9
           +NR  L+NS
Sbjct: 101 ENRDFLKNS 109
>XP_005267693
          Length = 1502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QNRSLLRNS 9
            QNR  +RNS
Sbjct: 1116 QNRIKIRNS 1124
>XP_005267692
          Length = 1502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QNRSLLRNS 9
            QNR  +RNS
Sbjct: 1116 QNRIKIRNS 1124
>XP_006719555
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RSLLRNS 9
           RSLL+NS
Sbjct: 451 RSLLKNS 457
>XP_005253638
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RSLLRNS 9
           RSLL+NS
Sbjct: 451 RSLLKNS 457
>XP_006719554
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RSLLRNS 9
           RSLL+NS
Sbjct: 612 RSLLKNS 618
>NP_056261
          Length = 2275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QNRSLLRNS 9
            + RSL RNS
Sbjct: 996  RERSLARNS 1004
>NP_036440
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NRSLLRN 8
            NRS LRN
Sbjct: 1034 NRSKLRN 1040
>NP_115979
          Length = 1336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NRSLLRN 8
            NRS LRN
Sbjct: 1208 NRSKLRN 1214
>NP_001127958
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QNRSLL 6
           QNRSLL
Sbjct: 562 QNRSLL 567
>NP_443174
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QNRSLL 6
           QNRSLL
Sbjct: 562 QNRSLL 567
>NP_006142
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QNRSLL 6
           QNRSLL
Sbjct: 211 QNRSLL 216
>NP_001005366
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NRSLLRN 8
            NRS LRN
Sbjct: 1139 NRSKLRN 1145
>NP_001153574
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QNRSLL 6
           QNRSLL
Sbjct: 128 QNRSLL 133
>NP_001243334
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NRSLLRN 8
           NRS LRN
Sbjct: 595 NRSKLRN 601
>NP_940931
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RSLLRN 8
           RSLLRN
Sbjct: 425 RSLLRN 430
>NP_001138525
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RSLLRN 8
           RSLLRN
Sbjct: 369 RSLLRN 374
>XP_005258606
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QNRSLL 6
           QNRSLL
Sbjct: 238 QNRSLL 243
>XP_006723100
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QNRSLL 6
           QNRSLL
Sbjct: 238 QNRSLL 243
>XP_006721944
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RSLLRN 8
           RSLLRN
Sbjct: 425 RSLLRN 430
>XP_006721943
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RSLLRN 8
           RSLLRN
Sbjct: 425 RSLLRN 430
>XP_006721942
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RSLLRN 8
           RSLLRN
Sbjct: 425 RSLLRN 430
>XP_005254018
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NRSLLRN 8
           NRS LRN
Sbjct: 648 NRSKLRN 654
>XP_005254013
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NRSLLRN 8
            NRS LRN
Sbjct: 1171 NRSKLRN 1177
>XP_005254012
          Length = 1305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NRSLLRN 8
            NRS LRN
Sbjct: 1177 NRSKLRN 1183
>XP_005254011
          Length = 1334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NRSLLRN 8
            NRS LRN
Sbjct: 1208 NRSKLRN 1214
>XP_006718544
          Length = 1056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NRSLLRN 8
           NRS LRN
Sbjct: 928 NRSKLRN 934
>XP_006718543
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NRSLLRN 8
           NRS LRN
Sbjct: 939 NRSKLRN 945
>XP_006718542
          Length = 1145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    NRSLLRN 8
            NRS LRN
Sbjct: 1017 NRSKLRN 1023
>XP_006711822
          Length = 2266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QNRSLLRNS 9
           + RSL RNS
Sbjct: 987 RERSLARNS 995
>XP_006711821
          Length = 2301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    QNRSLLRNS 9
            + RSL RNS
Sbjct: 1022 RERSLARNS 1030
>NP_653289
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   QNRSLL 6
           QNRSLL
Sbjct: 238 QNRSLL 243
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.120    0.292 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 384,502
Number of extensions: 710
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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