Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              21     229
NP_000126                                                              19     665
NP_001273096                                                           19     665
XP_005256351                                                           19     665
XP_006721231                                                           19     665
XP_006721230                                                           19     665
NP_877398                                                              18    1935
NP_056007                                                              18    1935
XP_005260738                                                           18    1935
XP_006723618                                                           18    1935
NP_001128119                                                           17    3301
NP_071895                                                              17    3301
XP_005255555                                                           17    3301
XP_006720985                                                           17    3301
XP_005255551                                                           17    3301
XP_006720984                                                           17    3301
XP_006720983                                                           17    3301
XP_006720982                                                           17    3301
XP_006720981                                                           17    3301
XP_006713971                                                           17    3301
NP_071746                                                              17    4312
NP_001139669                                                           17    4312
NP_001186068                                                           16    5631
NP_067032                                                              16    5631
NP_001186067                                                           16    5631
XP_006719000                                                           16    5631
NP_002998                                                              16    5631
NP_612351                                                              16    5631
NP_002999                                                              16    5631
NP_001243398                                                           16    7355
NP_036462                                                              16    7355
NP_001243397                                                           16    7355
NP_005543                                                              16    7355
NP_001123579                                                           16    7355
NP_891553                                                              16    7355
NP_001139280                                                           16    7355
NP_689503                                                              16    7355
NP_000623                                                              16    7355
NP_001093241                                                           16    7355
NP_644809                                                              16    7355
NP_001245134                                                           16    7355
NP_001077007                                                           16    7355
NP_001264012                                                           16    7355
NP_001264335                                                           16    7355
NP_001647                                                              16    7355
NP_940967                                                              16    7355
NP_659505                                                              16    7355
XP_005257884                                                           16    7355
XP_005257882                                                           16    7355
XP_006721108                                                           16    7355
XP_005269721                                                           16    7355
XP_005248554                                                           16    7355
XP_006712601                                                           16    7355
NP_001128712                                                           16    7355
NP_001683                                                              15    9605
NP_060785                                                              15    9605
NP_004787                                                              15    9605
NP_775760                                                              15    9605
NP_001275964                                                           15    9605
NP_001275963                                                           15    9605
NP_958930                                                              15    9605
NP_958929                                                              15    9605
NP_958931                                                              15    9605
XP_006720386                                                           15    9605
XP_006720385                                                           15    9605
XP_005268275                                                           15    9605
XP_006714502                                                           15    9605
XP_005264425                                                           15    9605
NP_001005365                                                           15    9605
NP_001002920                                                           15    9605
>NP_115803
          Length = 1156

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QNMGMYENL 9
           QNMGMY NL
Sbjct: 865 QNMGMYGNL 873
>NP_000126
          Length = 1455

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QNMGMYENL 9
           +NMG+YE+L
Sbjct: 526 ENMGLYEDL 534
>NP_001273096
          Length = 1424

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QNMGMYENL 9
           +NMG+YE+L
Sbjct: 526 ENMGLYEDL 534
>XP_005256351
          Length = 1463

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QNMGMYENL 9
           +NMG+YE+L
Sbjct: 526 ENMGLYEDL 534
>XP_006721231
          Length = 1114

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QNMGMYENL 9
           +NMG+YE+L
Sbjct: 185 ENMGLYEDL 193
>XP_006721230
          Length = 1412

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   QNMGMYENL 9
           +NMG+YE+L
Sbjct: 526 ENMGLYEDL 534
>NP_877398
          Length = 1173

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NMGMYE 7
           NMGMYE
Sbjct: 636 NMGMYE 641
>NP_056007
          Length = 1216

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NMGMYE 7
           NMGMYE
Sbjct: 636 NMGMYE 641
>XP_005260738
          Length = 877

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NMGMYE 7
           NMGMYE
Sbjct: 636 NMGMYE 641
>XP_006723618
          Length = 1173

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NMGMYE 7
           NMGMYE
Sbjct: 636 NMGMYE 641
>NP_001128119
          Length = 814

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMGMYENL 9
           N G+Y+NL
Sbjct: 533 NAGLYDNL 540
>NP_071895
          Length = 855

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNMGMYENL 9
           +N G+YEN+
Sbjct: 443 RNRGVYENV 451
>XP_005255555
          Length = 539

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNMGMYENL 9
           +N G+YEN+
Sbjct: 127 RNRGVYENV 135
>XP_006720985
          Length = 846

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNMGMYENL 9
           +N G+YEN+
Sbjct: 479 RNRGVYENV 487
>XP_005255551
          Length = 855

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNMGMYENL 9
           +N G+YEN+
Sbjct: 443 RNRGVYENV 451
>XP_006720984
          Length = 878

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNMGMYENL 9
           +N G+YEN+
Sbjct: 466 RNRGVYENV 474
>XP_006720983
          Length = 891

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNMGMYENL 9
           +N G+YEN+
Sbjct: 479 RNRGVYENV 487
>XP_006720982
          Length = 891

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNMGMYENL 9
           +N G+YEN+
Sbjct: 479 RNRGVYENV 487
>XP_006720981
          Length = 891

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNMGMYENL 9
           +N G+YEN+
Sbjct: 479 RNRGVYENV 487
>XP_006713971
          Length = 835

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMGMYENL 9
           N G+Y+NL
Sbjct: 554 NAGLYDNL 561
>NP_071746
          Length = 351

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  QNMGMYENL 9
          Q++G YEN+
Sbjct: 91 QHLGEYENV 99
>NP_001139669
          Length = 7081

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   QNMGMYE 7
           QN G+YE
Sbjct: 306 QNQGLYE 312
>NP_001186068
          Length = 1024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MGMYENL 9
           MG++ENL
Sbjct: 958 MGVFENL 964
>NP_067032
          Length = 1024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MGMYENL 9
           MG++ENL
Sbjct: 958 MGVFENL 964
>NP_001186067
          Length = 1024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MGMYENL 9
           MG++ENL
Sbjct: 958 MGVFENL 964
>XP_006719000
          Length = 636

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QNMGMYENL 9
           QN+G Y N+
Sbjct: 581 QNLGRYWNI 589
>NP_002998
          Length = 462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QNMGMYENL 9
           QN G Y+N+
Sbjct: 215 QNKGHYQNV 223
>NP_612351
          Length = 636

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QNMGMYENL 9
           QN+G Y N+
Sbjct: 581 QNLGRYWNI 589
>NP_002999
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QNMGMYENL 9
           QN G Y+N+
Sbjct: 215 QNKGHYQNV 223
>NP_001243398
          Length = 1781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMGMYENL 9
            N+G+YE +
Sbjct: 1499 NIGLYERM 1506
>NP_036462
          Length = 2073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMGMYENL 9
            N+G+YE +
Sbjct: 1791 NIGLYERM 1798
>NP_001243397
          Length = 1890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMGMYENL 9
            N+G+YE +
Sbjct: 1608 NIGLYERM 1615
>NP_005543
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QNMGMYENL 9
           QN G YE +
Sbjct: 350 QNQGKYEEV 358
>NP_001123579
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QNMGMYENL 9
           QN G YE +
Sbjct: 350 QNQGKYEEV 358
>NP_891553
          Length = 573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QNMGMYENL 9
           QN G YE +
Sbjct: 350 QNQGKYEEV 358
>NP_001139280
          Length = 1153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QNMGMYEN 8
           QN GM+E+
Sbjct: 437 QNTGMWES 444
>NP_689503
          Length = 194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NMGMYENL 9
           N G+YE L
Sbjct: 139 NYGLYEQL 146
>NP_000623
          Length = 1152

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QNMGMYEN 8
           QN GM+E+
Sbjct: 437 QNTGMWES 444
>NP_001093241
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMGMYENL 9
           N+G+ ENL
Sbjct: 426 NVGLLENL 433
>NP_644809
          Length = 153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  NMGMY 6
          NMGMY
Sbjct: 57 NMGMY 61
>NP_001245134
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QNMGMY 6
           Q+MGMY
Sbjct: 570 QSMGMY 575
>NP_001077007
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMGMYENL 9
           N+G+ ENL
Sbjct: 426 NVGLLENL 433
>NP_001264012
          Length = 1038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMGMYENL 9
           N+G+ ENL
Sbjct: 389 NVGLLENL 396
>NP_001264335
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMGMYENL 9
           N+G+ ENL
Sbjct: 426 NVGLLENL 433
>NP_001647
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   MGMYENL 9
           MG+YE L
Sbjct: 552 MGLYEGL 558
>NP_940967
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NMGMYENL 9
           NMG Y +L
Sbjct: 283 NMGFYRDL 290
>NP_659505
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QNMGMY 6
           Q+MGMY
Sbjct: 570 QSMGMY 575
>XP_005257884
          Length = 153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  NMGMY 6
          NMGMY
Sbjct: 57 NMGMY 61
>XP_005257882
          Length = 171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  NMGMY 6
          NMGMY
Sbjct: 75 NMGMY 79
>XP_006721108
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QNMGMYEN 8
           QN GM+E+
Sbjct: 437 QNTGMWES 444
>XP_005269721
          Length = 2073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    NMGMYENL 9
            N+G+YE +
Sbjct: 1791 NIGLYERM 1798
>XP_005248554
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   MGMYENL 9
           MG+YE L
Sbjct: 376 MGLYEGL 382
>XP_006712601
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NMGMYENL 9
          N+G+ ENL
Sbjct: 26 NVGLLENL 33
>NP_001128712
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  GMYENL 9
          GM+ENL
Sbjct: 43 GMFENL 48
>NP_001683
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NMGMYEN 8
           N G YEN
Sbjct: 458 NQGPYEN 464
>NP_060785
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  QNMGMYENL 9
          +NMG Y  L
Sbjct: 73 ENMGFYGTL 81
>NP_004787
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   GMYENL 9
           GMY NL
Sbjct: 627 GMYSNL 632
>NP_775760
          Length = 1585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   QNMGMYEN 8
           Q MG Y N
Sbjct: 600 QQMGSYSN 607
>NP_001275964
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   QNMGMYE 7
           QN G YE
Sbjct: 271 QNQGKYE 277
>NP_001275963
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   QNMGMYE 7
           QN G YE
Sbjct: 348 QNQGKYE 354
>NP_958930
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   QNMGMYE 7
           QN G YE
Sbjct: 348 QNQGKYE 354
>NP_958929
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   QNMGMYE 7
           QN G YE
Sbjct: 348 QNQGKYE 354
>NP_958931
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   QNMGMYE 7
           QN G YE
Sbjct: 366 QNQGKYE 372
>XP_006720386
          Length = 1571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    GMYENL 9
            GMY NL
Sbjct: 1000 GMYSNL 1005
>XP_006720385
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    GMYENL 9
            GMY NL
Sbjct: 1008 GMYSNL 1013
>XP_005268275
          Length = 1684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    GMYENL 9
            GMY NL
Sbjct: 1012 GMYSNL 1017
>XP_006714502
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  QNMGMYEN 8
          Q MG Y N
Sbjct: 83 QQMGSYSN 90
>XP_005264425
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   NMGMYEN 8
           N G YEN
Sbjct: 416 NQGPYEN 422
>NP_001005365
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMGMYENL 9
           N+G+ ENL
Sbjct: 352 NVGLSENL 359
>NP_001002920
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NMGMYENL 9
           N+G+ ENL
Sbjct: 306 NVGLSENL 313
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.130    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 507,140
Number of extensions: 807
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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