Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     390
NP_671714                                                              20     390
XP_006715890                                                           20     390
XP_005250160                                                           20     390
XP_005250159                                                           20     390
NP_001193874                                                           17    4312
NP_001193871                                                           17    4312
NP_006565                                                              17    4312
NP_001193872                                                           17    4312
XP_005271963                                                           17    4312
XP_006714622                                                           17    4312
XP_005271962                                                           17    4312
XP_006714621                                                           17    4312
NP_689761                                                              17    4312
NP_001257449                                                           16    5631
NP_055807                                                              16    5631
NP_001252541                                                           16    5631
NP_057368                                                              16    5631
NP_996882                                                              16    5631
XP_005267488                                                           16    5631
XP_005267487                                                           16    5631
NP_055803                                                              16    7355
NP_001276053                                                           16    7355
NP_001276051                                                           16    7355
NP_001106191                                                           16    7355
NP_001106190                                                           16    7355
NP_001106189                                                           16    7355
NP_001106188                                                           16    7355
NP_065166                                                              16    7355
XP_006723895                                                           16    7355
XP_006714061                                                           16    7355
XP_005248132                                                           16    7355
XP_005248131                                                           16    7355
XP_005248130                                                           16    7355
XP_005248129                                                           16    7355
XP_006714060                                                           16    7355
XP_005248128                                                           16    7355
XP_005248127                                                           16    7355
XP_005248126                                                           16    7355
XP_005248125                                                           16    7355
XP_005248124                                                           16    7355
XP_005248123                                                           16    7355
XP_005248122                                                           16    7355
XP_005248121                                                           16    7355
XP_005248120                                                           16    7355
XP_006714059                                                           16    7355
XP_005248119                                                           16    7355
XP_005248118                                                           16    7355
XP_005248117                                                           16    7355
XP_005248116                                                           16    7355
XP_005248115                                                           16    7355
XP_005248114                                                           16    7355
NP_001077368                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           QN+MSQKIE
Sbjct: 671 QNEMSQKIE 679
>NP_671714
          Length = 3899

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           QN+MSQKIE
Sbjct: 671 QNEMSQKIE 679
>XP_006715890
          Length = 3860

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           QN+MSQKIE
Sbjct: 671 QNEMSQKIE 679
>XP_005250160
          Length = 3939

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           QN+MSQKIE
Sbjct: 671 QNEMSQKIE 679
>XP_005250159
          Length = 3952

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           QN+MSQKIE
Sbjct: 671 QNEMSQKIE 679
>NP_001193874
          Length = 428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QNKMSQKIE 9
           QN MS K+E
Sbjct: 401 QNSMSPKLE 409
>NP_001193871
          Length = 401

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QNKMSQKIE 9
           QN MS K+E
Sbjct: 374 QNSMSPKLE 382
>NP_006565
          Length = 539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QNKMSQKIE 9
           QN MS K+E
Sbjct: 512 QNSMSPKLE 520
>NP_001193872
          Length = 566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   QNKMSQKIE 9
           QN MS K+E
Sbjct: 539 QNSMSPKLE 547
>XP_005271963
          Length = 248

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           +NK+S+K+E
Sbjct: 177 ENKLSKKME 185
>XP_006714622
          Length = 266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           +NK+S+K+E
Sbjct: 195 ENKLSKKME 203
>XP_005271962
          Length = 266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           +NK+S+K+E
Sbjct: 195 ENKLSKKME 203
>XP_006714621
          Length = 368

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           +NK+S+K+E
Sbjct: 297 ENKLSKKME 305
>NP_689761
          Length = 452

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   QNKMSQKIE 9
           +NK+S+K+E
Sbjct: 381 ENKLSKKME 389
>NP_001257449
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NKMSQKIE 9
           NKM +K+E
Sbjct: 488 NKMKEKLE 495
>NP_055807
          Length = 1078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NKMSQKIE 9
           NKM +K+E
Sbjct: 488 NKMKEKLE 495
>NP_001252541
          Length = 2371

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            Q+ M+QK+E
Sbjct: 1103 QSNMTQKVE 1111
>NP_057368
          Length = 2376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            Q+ M+QK+E
Sbjct: 1108 QSNMTQKVE 1116
>NP_996882
          Length = 1551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            Q+ M+QK+E
Sbjct: 1108 QSNMTQKVE 1116
>XP_005267488
          Length = 1078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NKMSQKIE 9
           NKM +K+E
Sbjct: 488 NKMKEKLE 495
>XP_005267487
          Length = 1078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NKMSQKIE 9
           NKM +K+E
Sbjct: 488 NKMKEKLE 495
>NP_055803
          Length = 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 698 ENEMSGKVE 706
>NP_001276053
          Length = 910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 527 ENEMSGKVE 535
>NP_001276051
          Length = 1069

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 686 ENEMSGKVE 694
>NP_001106191
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 532 ENEMSGKVE 540
>NP_001106190
          Length = 902

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 544 ENEMSGKVE 552
>NP_001106189
          Length = 1056

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 698 ENEMSGKVE 706
>NP_001106188
          Length = 1057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 698 ENEMSGKVE 706
>NP_065166
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NKMSQKIE 9
           NK+ QK+E
Sbjct: 360 NKVRQKVE 367
>XP_006723895
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NKMSQKIE 9
           NK+ QK+E
Sbjct: 360 NKVRQKVE 367
>XP_006714061
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 686 ENEMSGKVE 694
>XP_005248132
          Length = 1044

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 686 ENEMSGKVE 694
>XP_005248131
          Length = 1070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 686 ENEMSGKVE 694
>XP_005248130
          Length = 1074

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 686 ENEMSGKVE 694
>XP_005248129
          Length = 1082

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 698 ENEMSGKVE 706
>XP_006714060
          Length = 1085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 698 ENEMSGKVE 706
>XP_005248128
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 698 ENEMSGKVE 706
>XP_005248127
          Length = 1322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1242 ENEMSGKVE 1250
>XP_005248126
          Length = 1359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QNKMSQKIE 9
           +N+MS K+E
Sbjct: 971 ENEMSGKVE 979
>XP_005248125
          Length = 1439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1051 ENEMSGKVE 1059
>XP_005248124
          Length = 1467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1083 ENEMSGKVE 1091
>XP_005248123
          Length = 1471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1083 ENEMSGKVE 1091
>XP_005248122
          Length = 1471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1083 ENEMSGKVE 1091
>XP_005248121
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1155 ENEMSGKVE 1163
>XP_005248120
          Length = 1549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1161 ENEMSGKVE 1169
>XP_006714059
          Length = 1600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1242 ENEMSGKVE 1250
>XP_005248119
          Length = 1601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1242 ENEMSGKVE 1250
>XP_005248118
          Length = 1602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1242 ENEMSGKVE 1250
>XP_005248117
          Length = 1626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1242 ENEMSGKVE 1250
>XP_005248116
          Length = 1627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1242 ENEMSGKVE 1250
>XP_005248115
          Length = 1629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1242 ENEMSGKVE 1250
>XP_005248114
          Length = 1630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    QNKMSQKIE 9
            +N+MS K+E
Sbjct: 1242 ENEMSGKVE 1250
>NP_001077368
          Length = 620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   QNKMSQKI 8
           QNK +QK+
Sbjct: 552 QNKKTQKL 559
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.108    0.244 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 388,178
Number of extensions: 728
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package