Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004963                                                              21     229
XP_005251512                                                           21     229
NP_001243687                                                           20     509
XP_006722543                                                           20     509
NP_689683                                                              20     509
NP_068598                                                              17    3301
NP_620709                                                              17    4312
NP_620708                                                              17    4312
NP_001274433                                                           16    5631
NP_055491                                                              16    5631
NP_001018494                                                           16    5631
XP_005246870                                                           16    5631
XP_005246869                                                           16    5631
NP_001123917                                                           16    5631
NP_001274432                                                           16    5631
NP_006742                                                              16    5631
NP_001001976                                                           16    7355
NP_001275663                                                           16    7355
NP_004362                                                              16    7355
NP_001091868                                                           16    7355
NP_056132                                                              16    7355
NP_001269720                                                           16    7355
NP_001269681                                                           16    7355
NP_001269719                                                           16    7355
NP_116270                                                              16    7355
XP_005269518                                                           16    7355
XP_005269516                                                           16    7355
XP_005269515                                                           16    7355
XP_005269513                                                           16    7355
XP_005262667                                                           16    7355
XP_005262666                                                           16    7355
XP_006712038                                                           16    7355
XP_006712037                                                           16    7355
XP_006712036                                                           16    7355
XP_006712035                                                           16    7355
XP_005262664                                                           16    7355
NP_001004700                                                           16    7355
NP_115532                                                              15    9605
NP_076414                                                              15    9605
NP_001002259                                                           15    9605
NP_149043                                                              15    9605
NP_001193785                                                           15    9605
NP_003647                                                              15    9605
NP_008859                                                              15    9605
NP_775107                                                              15    9605
NP_001073906                                                           15    9605
NP_001264262                                                           15    9605
NP_001161946                                                           15    9605
NP_079161                                                              15    9605
NP_001186982                                                           15    9605
NP_001186983                                                           15    9605
XP_005262209                                                           15    9605
XP_005262208                                                           15    9605
XP_006724727                                                           15    9605
XP_003959998                                                           15    9605
XP_006719632                                                           15    9605
XP_006719631                                                           15    9605
XP_006719210                                                           15    9605
XP_006719209                                                           15    9605
XP_006719208                                                           15    9605
XP_006719207                                                           15    9605
XP_006719206                                                           15    9605
XP_006719205                                                           15    9605
XP_006719204                                                           15    9605
XP_006719203                                                           15    9605
XP_006719202                                                           15    9605
XP_006719201                                                           15    9605
XP_006719200                                                           15    9605
XP_005265573                                                           15    9605
XP_006712470                                                           15    9605
XP_006712469                                                           15    9605
XP_006712468                                                           15    9605
XP_005247054                                                           15    9605
>NP_004963
          Length = 1132

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QMVLHKIRN 9
           QMV HKIRN
Sbjct: 534 QMVFHKIRN 542
>XP_005251512
          Length = 1132

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QMVLHKIRN 9
           QMV HKIRN
Sbjct: 534 QMVFHKIRN 542
>NP_001243687
          Length = 154

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  QMVLHKIRN 9
          QMV+H+IRN
Sbjct: 12 QMVVHEIRN 20
>XP_006722543
          Length = 369

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   QMVLHKIRN 9
           QMV+H+IRN
Sbjct: 227 QMVVHEIRN 235
>NP_689683
          Length = 346

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   QMVLHKIRN 9
           QMV+H+IRN
Sbjct: 204 QMVVHEIRN 212
>NP_068598
          Length = 764

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QMVLHKIR 8
           +++LHK+R
Sbjct: 145 ELILHKVR 152
>NP_620709
          Length = 424

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMVLHKI 7
           +MVLHK+
Sbjct: 217 EMVLHKV 223
>NP_620708
          Length = 382

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMVLHKI 7
           +MVLHK+
Sbjct: 217 EMVLHKV 223
>NP_001274433
          Length = 1084

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLHKIRN 9
           VLH IRN
Sbjct: 763 VLHDIRN 769
>NP_055491
          Length = 1186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QMVLHKIR 8
            ++V+HKIR
Sbjct: 1138 KIVMHKIR 1145
>NP_001018494
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QMVLHKIR 8
            ++V+HKIR
Sbjct: 1140 KIVMHKIR 1147
>XP_005246870
          Length = 1252

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLHKIRN 9
           VLH IRN
Sbjct: 916 VLHDIRN 922
>XP_005246869
          Length = 1255

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLHKIRN 9
           VLH IRN
Sbjct: 916 VLHDIRN 922
>NP_001123917
          Length = 1259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLHKIRN 9
           VLH IRN
Sbjct: 916 VLHDIRN 922
>NP_001274432
          Length = 1237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLHKIRN 9
           VLH IRN
Sbjct: 916 VLHDIRN 922
>NP_006742
          Length = 1256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VLHKIRN 9
           VLH IRN
Sbjct: 916 VLHDIRN 922
>NP_001001976
          Length = 518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QMVLHK 6
           QMV+HK
Sbjct: 299 QMVIHK 304
>NP_001275663
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QMVLHK 6
           QMV+HK
Sbjct: 184 QMVIHK 189
>NP_004362
          Length = 1224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VLHKIRN 9
           VLH +RN
Sbjct: 611 VLHMVRN 617
>NP_001091868
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VLHKIRN 9
           VLH +RN
Sbjct: 620 VLHMVRN 626
>NP_056132
          Length = 1064

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    QMVLHKIR 8
            ++++HKIR
Sbjct: 1016 KIIMHKIR 1023
>NP_001269720
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QMVLHKIR 8
           ++++HKIR
Sbjct: 881 KIIMHKIR 888
>NP_001269681
          Length = 1008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QMVLHKIR 8
           ++++HKIR
Sbjct: 960 KIIMHKIR 967
>NP_001269719
          Length = 985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QMVLHKIR 8
           ++++HKIR
Sbjct: 937 KIIMHKIR 944
>NP_116270
          Length = 123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3   VLHKIRN 9
           ++H++RN
Sbjct: 100 IIHRVRN 106
>XP_005269518
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QMVLHK 6
           QMV+HK
Sbjct: 316 QMVIHK 321
>XP_005269516
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QMVLHK 6
           QMV+HK
Sbjct: 292 QMVIHK 297
>XP_005269515
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QMVLHK 6
           QMV+HK
Sbjct: 299 QMVIHK 304
>XP_005269513
          Length = 578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   QMVLHK 6
           QMV+HK
Sbjct: 316 QMVIHK 321
>XP_005262667
          Length = 985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QMVLHKIR 8
           ++++HKIR
Sbjct: 937 KIIMHKIR 944
>XP_005262666
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QMVLHKIR 8
           ++++HKIR
Sbjct: 939 KIIMHKIR 946
>XP_006712038
          Length = 1010

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   QMVLHKIR 8
           ++++HKIR
Sbjct: 962 KIIMHKIR 969
>XP_006712037
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    QMVLHKIR 8
            ++++HKIR
Sbjct: 1018 KIIMHKIR 1025
>XP_006712036
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    QMVLHKIR 8
            ++++HKIR
Sbjct: 1018 KIIMHKIR 1025
>XP_006712035
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    QMVLHKIR 8
            ++++HKIR
Sbjct: 1018 KIIMHKIR 1025
>XP_005262664
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    QMVLHKIR 8
            ++++HKIR
Sbjct: 1018 KIIMHKIR 1025
>NP_001004700
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MVLHKIRN 9
           ++LH +RN
Sbjct: 218 VILHSLRN 225
>NP_115532
          Length = 960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>NP_076414
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>NP_001002259
          Length = 1127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>NP_149043
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 882 HKIRN 886
>NP_001193785
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>NP_003647
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VLHKIRN 9
          VLHKI++
Sbjct: 69 VLHKIKH 75
>NP_008859
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMVLHKI 7
           Q+VLH+I
Sbjct: 551 QLVLHQI 557
>NP_775107
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   LHKIRN 9
           LHK++N
Sbjct: 379 LHKVKN 384
>NP_001073906
          Length = 1413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    QMVLHKIRN 9
            Q  LH+IR+
Sbjct: 1024 QWALHRIRH 1032
>NP_001264262
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VLHKIRN 9
           ++HKI+N
Sbjct: 331 LIHKIKN 337
>NP_001161946
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LHKIRN 9
           LHKI+N
Sbjct: 319 LHKIQN 324
>NP_079161
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LHKIRN 9
           LHKI+N
Sbjct: 405 LHKIQN 410
>NP_001186982
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMVLHKI 7
           Q+VLH+I
Sbjct: 465 QLVLHQI 471
>NP_001186983
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMVLHKI 7
           Q+VLH+I
Sbjct: 551 QLVLHQI 557
>XP_005262209
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LHKIRN 9
           LHKI+N
Sbjct: 320 LHKIQN 325
>XP_005262208
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LHKIRN 9
           LHKI+N
Sbjct: 331 LHKIQN 336
>XP_006724727
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LHKIRN 9
           LHKI+N
Sbjct: 406 LHKIQN 411
>XP_003959998
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  VLHKIRN 9
          ++HKI+N
Sbjct: 53 LIHKIKN 59
>XP_006719632
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMVLHKI 7
           Q+VLH+I
Sbjct: 551 QLVLHQI 557
>XP_006719631
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMVLHKI 7
           Q+VLH+I
Sbjct: 554 QLVLHQI 560
>XP_006719210
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_006719209
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_006719208
          Length = 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_006719207
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_006719206
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5  HKIRN 9
          HKIRN
Sbjct: 50 HKIRN 54
>XP_006719205
          Length = 1057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_006719204
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_006719203
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_006719202
          Length = 1092

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_006719201
          Length = 1106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_006719200
          Length = 1126

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HKIRN 9
           HKIRN
Sbjct: 131 HKIRN 135
>XP_005265573
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VLHKIRN 9
          VLHKI++
Sbjct: 69 VLHKIKH 75
>XP_006712470
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    QMVLHKIRN 9
            Q  LH+IR+
Sbjct: 1024 QWALHRIRH 1032
>XP_006712469
          Length = 1380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    QMVLHKIRN 9
            Q  LH+IR+
Sbjct: 1024 QWALHRIRH 1032
>XP_006712468
          Length = 1413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    QMVLHKIRN 9
            Q  LH+IR+
Sbjct: 1024 QWALHRIRH 1032
>XP_005247054
          Length = 1434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    QMVLHKIRN 9
            Q  LH+IR+
Sbjct: 1024 QWALHRIRH 1032
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.139    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 481,650
Number of extensions: 534
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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