Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     299
NP_001091680                                                           20     299
NP_001091679                                                           20     299
XP_006713048                                                           20     299
XP_006713047                                                           20     299
XP_006713046                                                           20     299
XP_005264943                                                           20     299
NP_075252                                                              19     869
NP_998812                                                              19     869
NP_002002                                                              19     869
XP_005265895                                                           19     869
XP_005265894                                                           19     869
NP_005088                                                              16    5631
NP_001274103                                                           16    5631
NP_000343                                                              16    5631
NP_001013725                                                           16    5631
XP_005254450                                                           16    5631
XP_005254449                                                           16    5631
XP_006718349                                                           16    5631
XP_006717822                                                           16    5631
NP_149055                                                              16    7355
XP_005246793                                                           16    7355
XP_005246792                                                           16    7355
XP_005246791                                                           16    7355
XP_005246790                                                           16    7355
XP_005246789                                                           16    7355
NP_060764                                                              15    9605
NP_054644                                                              15    9605
NP_000784                                                              15    9605
NP_001007024                                                           15    9605
NP_001258563                                                           15    9605
NP_001229431                                                           15    9605
NP_005435                                                              15    9605
NP_001258564                                                           15    9605
NP_001229432                                                           15    9605
XP_005268698                                                           15    9605
XP_006712895                                                           15    9605
XP_005247000                                                           15    9605
XP_005246999                                                           15    9605
NP_001004134                                                           15    9605
>NP_001895
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           QMLKH VVN
Sbjct: 130 QMLKHAVVN 138
>NP_001091680
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           QMLKH VVN
Sbjct: 130 QMLKHAVVN 138
>NP_001091679
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           QMLKH VVN
Sbjct: 130 QMLKHAVVN 138
>XP_006713048
          Length = 720

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           QMLKH VVN
Sbjct: 130 QMLKHAVVN 138
>XP_006713047
          Length = 774

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           QMLKH VVN
Sbjct: 123 QMLKHAVVN 131
>XP_006713046
          Length = 774

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           QMLKH VVN
Sbjct: 123 QMLKHAVVN 131
>XP_005264943
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           QMLKH VVN
Sbjct: 130 QMLKHAVVN 138
>NP_075252
          Length = 762

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           Q LKH+V+N
Sbjct: 282 QWLKHIVIN 290
>NP_998812
          Length = 802

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           Q LKH+V+N
Sbjct: 282 QWLKHIVIN 290
>NP_002002
          Length = 802

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           Q LKH+V+N
Sbjct: 282 QWLKHIVIN 290
>XP_005265895
          Length = 802

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           Q LKH+V+N
Sbjct: 282 QWLKHIVIN 290
>XP_005265894
          Length = 834

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           Q LKH+V+N
Sbjct: 314 QWLKHIVIN 322
>NP_005088
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   QMLKHVVVN 9
           Q+ KHV+V+
Sbjct: 546 QIYKHVIVD 554
>NP_001274103
          Length = 1582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QMLKHVVV 8
            Q+LKH+V+
Sbjct: 1020 QLLKHMVL 1027
>NP_000343
          Length = 1581

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QMLKHVVV 8
            Q+LKH+V+
Sbjct: 1019 QLLKHMVL 1026
>NP_001013725
          Length = 1649

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QMLKHVVVN 9
           Q+LKH  +N
Sbjct: 532 QLLKHSFIN 540
>XP_005254450
          Length = 1505

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QMLKHVVVN 9
           Q+LKH  +N
Sbjct: 532 QLLKHSFIN 540
>XP_005254449
          Length = 1626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QMLKHVVVN 9
           Q+LKH  +N
Sbjct: 532 QLLKHSFIN 540
>XP_006718349
          Length = 1646

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    QMLKHVVV 8
            Q+LKH+V+
Sbjct: 1019 QLLKHMVL 1026
>XP_006717822
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   QMLKHVVVN 9
           Q +KH +VN
Sbjct: 777 QFVKHQIVN 785
>NP_149055
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QMLKHVVVN 9
           Q   HV+VN
Sbjct: 593 QFFDHVIVN 601
>XP_005246793
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QMLKHVVVN 9
           Q   HV+VN
Sbjct: 518 QFFDHVIVN 526
>XP_005246792
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QMLKHVVVN 9
           Q   HV+VN
Sbjct: 535 QFFDHVIVN 543
>XP_005246791
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QMLKHVVVN 9
           Q   HV+VN
Sbjct: 549 QFFDHVIVN 557
>XP_005246790
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QMLKHVVVN 9
           Q   HV+VN
Sbjct: 558 QFFDHVIVN 566
>XP_005246789
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   QMLKHVVVN 9
           Q   HV+VN
Sbjct: 569 QFFDHVIVN 577
>NP_060764
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KHVVVN 9
           KH+VVN
Sbjct: 339 KHLVVN 344
>NP_054644
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  MLKHVVV 8
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>NP_000784
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  MLKHVVV 8
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>NP_001007024
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  MLKHVVV 8
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>NP_001258563
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMLKHVV 7
           ++LKHVV
Sbjct: 259 RLLKHVV 265
>NP_001229431
          Length = 146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  MLKHVVV 8
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>NP_005435
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMLKHVV 7
           ++LKHVV
Sbjct: 227 RLLKHVV 233
>NP_001258564
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMLKHVV 7
           ++LKHVV
Sbjct: 227 RLLKHVV 233
>NP_001229432
          Length = 110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  MLKHVVV 8
          +LKHVV+
Sbjct: 33 LLKHVVL 39
>XP_005268698
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QMLKHVVV 8
          QML H+VV
Sbjct: 85 QMLIHLVV 92
>XP_006712895
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMLKHVV 7
           ++LKHVV
Sbjct: 174 RLLKHVV 180
>XP_005247000
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMLKHVV 7
           ++LKHVV
Sbjct: 229 RLLKHVV 235
>XP_005246999
          Length = 301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   QMLKHVV 7
           ++LKHVV
Sbjct: 229 RLLKHVV 235
>NP_001004134
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  QMLKHVVV 8
          QML H+VV
Sbjct: 81 QMLIHLVV 88
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.134    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 517,038
Number of extensions: 683
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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